Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

The Cuscuta kotschyana effects on breast cancer cells line MCF7

Mozhgan Farzami Sepehr 1*, Seyed Behnameddin Jameie2 and Bahareh Hajijafari3
1Department of Biology, Saveh Branch, Islamic Azad University, Saveh, Iran. 2Basic Sciences Laboratory, Basic Science Department, Faculty of Allied Medicine, Cellular and Molecular Research Center and Department of Anatomy, Faculty of Medicine, Iran University of Medical Science, Tehran, Iran. 3Department of Biology, Faculty of Science, Payame –Noor University, Tehran.Iran.
Email: [email protected]

  •  Accepted: 09 September 2011
  •  Published: 23 November 2011


Cuscuta kotschyana Boiss is classified as a member of Convolvulaceae family. This plant is mainly a central Asian taxon. Cuscuta is a parasitic plant that wraps around other plants for nourishment. Previous studies have indicated that Cuscuta could possess anticancer and immunostimulatory activities. The chemical constituents of Cuscuta mainly comprise flavonols like quercetin, kaempferol and other glycosids. These compounds maybe responsible for the biological activities of this plant. In the present study, the effects of flavonoid extracts of Cuscuta seed stem and its host plant (vine) was investigated on the growth of breast cancer cell line (MCF-7). The HPLC assay revealed that quercetin is the major compound in the extracts. The MTT assay revealed that after treatment with stem and seed extracts, reduced cell viability in MCF-7 cell line in a dose and time dependent manner. The anti proliferative effect of stem extract was significant from 50 µg/ml, and the inhibitory effect of seed extract was significant at 100 µg/ml, after 48 and 72 h. Annexin assay and flow cytometry analysis also showed these extracts (100 µg/ml seed) and (50 µg/ml stem) induced apoptosis 51 and 34%, respectively in MCF-7 cells after 72 h. These finding suggest that the flavonoid extract of Cuscuta could be useful in breast cancer treatment.  


Key words: Cuscuta, dodder plant, flavonoids, MCF7 cells, apoptosis.