Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3570

Full Length Research Paper

In vitro antiviral activity of Brazilian Cerrado plant extracts against animal and human herpesviruses

Marina A. Padilla
  • Marina A. Padilla
  • Centro de Pesquisa e Desenvolvimento de Sanidade Animal, Instituto Biológico, Av. Cons. Rodrigues Alves, 1252, CEP 04014-900, São Paulo, SP, Brasil.
  • Google Scholar
Isabela C. Simoni
  • Isabela C. Simoni
  • Centro de Pesquisa e Desenvolvimento de Sanidade Animal, Instituto Biológico, Av. Cons. Rodrigues Alves, 1252, CEP 04014-900, São Paulo, SP, Brasil.
  • Google Scholar
Veronica Moreira H. Hoe
  • Veronica Moreira H. Hoe
  • Centro de Pesquisa e Desenvolvimento de Sanidade Animal, Instituto Biológico, Av. Cons. Rodrigues Alves, 1252, CEP 04014-900, São Paulo, SP, Brasil.
  • Google Scholar
Maria Judite B. Fernandes
  • Maria Judite B. Fernandes
  • Centro de Pesquisa e Desenvolvimento de Sanidade Animal, Instituto Biológico, Av. Cons. Rodrigues Alves, 1252, CEP 04014-900, São Paulo, SP, Brasil.
  • Google Scholar
Clarice W. Arns
  • Clarice W. Arns
  • Laboratório de Virologia Animal, Universidade Estadual de Campinas, Campinas, SP, Brasil.
  • Google Scholar
Juliana R. Brito
  • Juliana R. Brito
  • Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, São Paulo, Brazil.
  • Google Scholar
João Henrique G. Lago
  • João Henrique G. Lago
  • Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, São Paulo, Brazil.
  • Google Scholar


  •  Received: 09 February 2018
  •  Accepted: 16 March 2018
  •  Published: 24 March 2018

Abstract

The Brazilian savanna known as “Cerrado” is very rich in medicinal plants that are used by the local population for treatment of several illnesses. The herpesvirus is a serious problem worldwide, and affects both animal and human health. This work aimed to study the antiviral activity of eight extracts from plants natives of “Cerrado” region against human (HSV-1), equine (EqHV-1) and swine herpesviruses (SuHV-1). The results showed that all plant extracts: Banisteriopsis variabilis, Byrsonima intermedia, Campomanesia xanthocarpa, Erythroxilum deciduum, Lacistema hasslerianum, Ocotea pulchella, Stryphodendron adstringens and Xylopia aromatica presented antiviral activity against at least one herpesvirus. Furthermore, it was observed a direct anti-herpes effect of extracts from B. variabilis and B. intermedia in non-toxic concentrations against all herpesviruses. B. intermedia crude aqueous extract showed the most promising results with selective index values of the 41.76 ± 0.04; 4.12 ± 0.1 and 193.97 ± 0.09 respectively against HSV-1, EqHV-1 and SuHV-1. Due to this, B. intermedia extract was also analyzed by HPLC/MS allowing for the identification of gallic acid and quercetin as main compounds.

Key words: Brazilian savanna, Cerrado, Byrsonima intermedia, antiviral, herpesvirus, gallic acid, quercetin.