Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3830

Review

Molecular regulation of terpenoid indole alkaloids pathway in the medicinal plant, Catharanthus roseus

Mei-Liang Zhou1,2, Hong-Li Hou3, Xue-Mei Zhu4, Ji-Rong Shao1, Yan-Min Wu2 and Yi-Xiong Tang2*
1The School of Life Science, Sichuan Agricultural University, Yaan, Sichuan, 625014, People’s Republic of China. 2Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing, 100081, People’s Republic of China. 3Shenzhen Imported Center for Quality Crop Seed, Shenzhen, Guangdong, 518040, People’s Republic of China. 4The School of Resources and Environment, Sichuan Agricultural University, Yaan, Sichuan, 625014, People’s Republic of China.
Email: [email protected]

  •  Accepted: 16 September 2010
  •  Published: 29 December 2010

Abstract

Catharanthus roseus (L.) is a plant species known for its production of many pharmaceutically terpenoid indole alkaloids (TIAs). The intricate networks of TIAs biosynthesis is regulated by all kinds of molecules such as plant signaling molecules (jasmonate acid, ethylene and nitric oxide), plant growth regulators, prenylated proteins and transcription factors. This fine-tuned regulation is also accompanied with compartmentalization and transportation of various alkaloids in different parts of C. roseus. In this paper, we present an analysis of the state of the art related to these molecules regulation mechanism in the TIAs pathway in C. roseus.

 

Key words: Compartmentalization, indole alkaloid, jasmonate, nitric oxide, phytohormone, prenylated proteins.

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