Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3702

Full Length Research Paper

Effect of Ginkgo biloba extract on sperm quality, serum testosterone concentration and histometric analysis of testes from adult Wistar rats

Leonardo Toshio Oshio*,
  • Leonardo Toshio Oshio*,
  • Federal University of Juiz de Fora, Brazil.
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Cláudia Cristina Teixeira Ribeiro
  • Cláudia Cristina Teixeira Ribeiro
  • Federal University of Juiz de Fora, Brazil.
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Renato Macedo Marques
  • Renato Macedo Marques
  • Federal University of Juiz de Fora, Brazil.
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Martha de Oliveira Guerra
  • Martha de Oliveira Guerra
  • Federal University of Juiz de Fora, Brazil.
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Sérgio Luis Pinto da Matta
  • Sérgio Luis Pinto da Matta
  • Federal University of Juiz de Fora, Brazil.
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João Evangelista de Paula Reis
  • João Evangelista de Paula Reis
  • Federal University of Juiz de Fora, Brazil.
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Rita de Cássia da Silveira e Sá
  • Rita de Cássia da Silveira e Sá
  • Federal University of Juiz de Fora, Brazil.
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Leandro Vespoli Campos
  • Leandro Vespoli Campos
  • Federal University of Juiz de Fora, Brazil.
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Vera Maria Peters
  • Vera Maria Peters
  • Federal University of Juiz de Fora, Brazil.
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  •  Received: 12 January 2014
  •  Accepted: 02 February 2015
  •  Published: 03 February 2015

Abstract

Ginkgo biloba extract is a widely consumed phytotherapic used mainly in the treatment of dementia and Alzheimer’s disease, and it has also been employed to treat erectile dysfunction and as an aphrodisiac. This work was aimed at evaluating its effect on sperm quality, serum testosterone concentration and on the histometric analysis of the testes from adult male Wistar rats. Three-month-old Wistar rats were treated with distilled water (control group) and the aqueous extract of Ginkgo biloba at the dose levels of 3.5 (GBE 3.5); 7.0 (GBE 7.0) and 14.0 mg/kg (GBE 14.0), once daily, for 56 consecutive days. Counting and morphological evaluation of sperm collected from cauda epidydimis were analyzed. Histometric measures of the testes were also taken. This work shows that adult Wistar rats exposed to Ginkgo biloba presented histometric alteration in the volume of the Leydig cells and this finding suggests a possible functional deficit in these cells.

 

Key words: Ginkgo biloba, phytotherapy, rats, sperm, testes, toxicity.