Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3753

Full Length Research Paper

Antimicrobial activity of Pityrocarpa monilifomis leaves and its capacity to enhance the activity of four antibiotics against Staphylococcus aureus strains

Juliette Ferreira Vieira da Silva1, Luís Cláudio Nascimento da Silva2, Isabel Renata de Souza Arruda1, Alexandre Gomes da Silva1, Alexandre José Macedo3, Janete Magali de Araújo4, Maria Tereza dos Santos Correia2 and Márcia Vanusa da Silva1*
1Laboratório de Produtos Naturais, Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Pernambuco. Av. Prof. Moraes Rego, s/n, CEP 50.670-420. Recife, PE, Brazil. 2Laboratório de Glicoproteínas, Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego, s/n, CEP 50.670-420. Recife, Brazil. 3Universidade Federal do Rio Grande do Sul, Faculdade de Farmácia and Centro de Biotecnologia, Av. Ipiranga, 2752 Porto Alegre, RS, CEP 90610-000, Brazil. 4Laboratório de Genética de Microrganismos, Departamento de Antibióticos, Centro de Ciências Biológicas, Universidade Federal de Pernambuco. Av. Prof. Moraes Rego, s/n, CEP 50.670-420. Recife, PE, Brazil.
Email: [email protected]

  •  Accepted: 12 July 2013
  •  Published: 25 July 2013

Abstract

This work evaluated the antimicrobial activity of Pityrocarpa monilifomis leaves and the effects of extract and two active fractions in combination with four antibiotics againstStaphylococcus aureus strains. The extract only inhibited Gram positive bacteria, whereas the fractions also showed activity against Gram negative organism. Only n-butanol fraction showed synergistic/additive effects with all tested drug. Certainly as a consequence of saponin presence (it has a great hemolytic capacity). This study showed at first time the antimicrobial activity extract/fractions of leaves from P. moniliformis and their capacity to enhance the anti-S. aureus activity of some protein inhibitors drugs.

 

Key words: Caatinga, saponins, synergism, Pityrocarpa moniliformis, antimicrobial.