Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3785

Full Length Research Paper

A Chinese herbal medicine production of anxiolytic and cognitive enhancing effects in a rat model of posttraumatic stress disorder

Zhen-Wu Su, Xue-Kun Zhang, Li-Ping Hou, Chun-Yan Gao, Jing Shan, Jing-Rui Li, Hong-Xia Li, Dong-Mei Wang, Jun-Qi Ying and Hong-Mei Liu*
Harrison International Peace Hospital, Hengshui, China.
Email: [email protected]

  •  Accepted: 22 December 2011
  •  Published: 09 March 2012


Free and Easy Wanderer Plus (FEWP) is a traditional Chinese medicine that has been used to treat stress- and depression-related diseases in China. To study the effects of FEWP on post-traumatic stress disorder (PTSD), the present study investigated how chronic treatment with FEWP affected rodent behaviors in a modified single-prolonged stress and shock (SPS and S) model, which induces certain behavioral manifestations similar to those seen in PTSD patients. Locomotor activities (LMA), elevated Plus Maze (EPM), and Morris Water Maze (MWM) tests were used to determine its effects on general locomotion, anxiety and cognitive functions following traumatic exposure. The results showed that SPS and S impaired performance in MWM and produced anxiogenic-like effects in EPM, both of which were significantly ameliorated by chronic treatment of FEWP at doses of 5 and 10 mg/kg/d. The effects of FEWP were not due to changes in locomotion. The current findings provide strong evidence that FEWP may be a useful drug for treating PTSD.


Key words: Single prolonged stress and shock, post-traumatic stress disorder, Morris water maze, open field, elevated plus maze.