Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3785

Full Length Research Paper

Analgesic, anti-inflammatory and oxytocic activities of Dracaena steudneri Engl. stem bark aqueous extract in Wistar rats

Mercy Gladys Tenywa
  • Mercy Gladys Tenywa
  • Pharm-Biotechnology and Traditional Medicine Center, Mbarara University of Science and Technology, Mbarara Uganda.
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Amon Ganafa Agaba
  • Amon Ganafa Agaba
  • Department of Pharmacology, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda.
  • Google Scholar
Clement Olusoji Ajayi
  • Clement Olusoji Ajayi
  • Pharm-Biotechnology and Traditional Medicine Center, Mbarara University of Science and Technology, Mbarara Uganda.
  • Google Scholar
Casim Umba Tolo
  • Casim Umba Tolo
  • Pharm-Biotechnology and Traditional Medicine Center, Mbarara University of Science and Technology, Mbarara Uganda.
  • Google Scholar
Esther Katuura
  • Esther Katuura
  • Department of Plant Science, Microbiology and Biotechnology, College of Natural Sciences, Makerere University, Kampala, Uganda.
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  •  Received: 18 May 2021
  •  Accepted: 24 February 2022
  •  Published: 30 April 2022

Abstract

Dracaena steudneri Engl. (Dracaenaceae) is a medicinal plant that is used in labour by traditional birth attendants to induce labour, relieve pain and treat various diseases; albeit no documentation. This study determined the analgesic, anti-inflammatory and oxytocic effects of the D. steudneri stem bark aqueous extract. D. steudneri stem bark was collected, authenticated, oven-dried at 45ºC for 48 h, pulverized and extracted using the decoction method. The analgesic effect of the aqueous extract was determined using the acetic acid writhing test, anti-inflammatory activity was determined using paw oedema method while oxytocic activity was determined using abortion and other standard test procedures and were tested at 12.1 24.1 and 48.2 mg/kg. The results of the analgesic study showed that the extract reduced the number of abdominal writhing between 53.51 and 92.40% at 6.02 and 48.2 mg/kg dose, respectively while the standard drug showed a reduction of 36.58% at 10 mg/kg. The anti-inflammatory results showed percentage inhibition of 18.6% (2 h), 22% (2 h) and 18.9% (6 h) at 12.1, 24.1 and 48.2 mg/kg, respectively. The in vivo oxytocic activity showed average time taken for the rats to deliver was between 20.63 h at lowest dose (12.1 mg/kg) and 8.25 h at highest dose (48.0 mg/kg) while Oxytocin the reference drug exhibited, 22 h as the average time taken for delivery.

Key words: Analgesic, oxytocic, anti-inflammatory and obstetrics.