Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3684

Full Length Research Paper

Ethnobotanical study of medicinal plants used to manage HIV/AIDS opportunistic infections in Rungwe, Mbeya Region, Tanzania

Suma F. Kibonde
  • Suma F. Kibonde
  • Department of Geography and Environmental Studies, Solomon Mahlangu College of Science and Education, Sokoine University of Agriculture, P.O. Box 3038, Chuo Kikuu, Morogoro, Tanzania.
  • Google Scholar
Suzana Augustino
  • Suzana Augustino
  • Department of Forest Engineering and Wood Sciences, College of Forestry, Wildlife and Tourism, Sokoine University of Agriculture, P.O. Box 3014 Chuo Kikuu, Morogoro, Tanzania.
  • Google Scholar
Faith P. Mabiki
  • Faith P. Mabiki
  • Department of Chemistry and Physics, Solomon Mahlangu College of Science and Education, Sokoine University of Agriculture, P.O. Box 3038, Chuo Kikuu, Morogoro, Tanzania.
  • Google Scholar
Robinson Mdegela
  • Robinson Mdegela
  • Department of Public Health, College of Veterinary and Medical Sciences (CVMS), Sokoine University of Agriculture, P.O. Box 3021 - Chuo Kikuu, Morogoro,Tanzania.
  • Google Scholar


  •  Received: 19 August 2017
  •  Accepted: 21 December 2017
  •  Published: 10 January 2018

 ABSTRACT

The current ethnobotanical study identified medicinal plant species used to manage HIV/AIDS opportunistic infections by the communities in Rungwe District, Tanzania. Data were collected using questionnaires (n=193), interviews (n=9) and field observations. A total of 31 plant species from 23 families are used in managing HIV/AIDS opportunistic infections. Compositae and Rosaceae were predominantly used in disease management by 15% each. Of the plant parts, leaves were the most used (44%), followed by roots (28%), bark (7%), fruits, seeds and stem (5%) while the least used plant parts were tubers (4%) and the whole (2%). Tuberculosis utilized 60% of the species, Herpes simplex 55%, chronic diarrhea 40%, oral candidiasis 35% and Herpes zoster 30%. Dissotis phaeotricha scored the highest fidelity value (73%), followed by Berberis holstii (60%). The knowledge on medicinal plants among respondents was influenced by; informal education (p<0.01), village location (p<0.01) and ethnic background (p<0.05). The study exposed the presence of reasonable knowledge of traditional medicinal plants among communities in Rungwe District. The results contribute to the conservation of experimental experiential knowledge of medicinal plants used in the management of HIV/AIDS opportunistic infections hence, shouldering world’s efforts geared towards anti-HIV/AIDS innovations.

Key words: Ethnobotany, conservation, medicinal plants, traditional practitioner.


 INTRODUCTION

Medicinal plant products constitute the largest percent of traditional medicine which anchors the lives of majority (Zhou, 2015). The reports by the world health organization (WHO) confirm that 80% of the world’s population in developing countries rely on traditional medicine (WHO, 2013). The importance of traditional medicinal plants in people’s welfare is opened for studies across the world. According toKisangau et al. (2007)and Bukuluki et al. (2014), 60% of the Tanzanians rely on traditional medicine for their primary health care. Generally, the use of medicinal plants has been reported to rise (Moshi et al., 2010; Ekor, 2014;Agisho et al., 2014). The reasons attributed to the trend include; constraints associated with the antiretroviral therapies (Chinsembu and Hedimbi, 2010), modern drug resistance in managing some diseases including HIV/AIDS opportunistic infections and conceived side effects of conventional medicine (Mustapha, 2014), the existing shortage of modern health personnel and stigma (Chinsembu, 2016; Denver et al., 2014).
 
The current reports by WHO and the United Nations AIDS (UNAIDS), cited by the Tanzanian national AIDS control programme (NACP), indicate that 36.7 million people across the world nations were living with HIV at the end of 2015, with 2.1 million new infections, and 1.1 million people died of HIV/AIDS opportunistic infections (NACP, 2016).
In general, morbidity and mortality among the people living with HIV/AIDS are connected to related infections (Yineger et al., 2007). In sub-Saharan Africa, the number of AIDS-related deaths was cut down by 39% in 2013, but, still there are many people (74%) who were reported to die from HIV/AIDS-opportunistic infections such as tuberculosis (TB), candidiasis, herpes simplex and herpes zoster (UNAIDS, 1998;Kisangau et al., 2011).
 
Runyoro et al. (2006), Kisangau et al. (2011), Magadula et al. (2014) and Omolo et al. (2014), conducted studies on medicinal plants which are used in managing HIV/AIDS opportunistic infections in Tanzania. The studies have revealed sound knowledge of plant species used by HIV/AIDS patients in managing opportunistic infections. However, most of the identified species varied among communities; the difference indicate the importance of considering the background of communities when studying knowledge about medicinal plants. Hence, this study was carried out to assess the knowledge of medicinal plants by communities in Rungwe District.


 MATERIALS AND METHODS

Study area
 
Rungwe District is located between latitudes 08°30' and 09°30' south of the Equator and longitudes 33°00' and 34°00' east of the Greenwich Meridian (Figure 1). Rungwe District (the highest altitudes of Rungwe and Poroto have attracted valuable forests for medicinal plant species) rises up between 770 and 2865 meters above sea level making it one of the mountainous districts in Tanzania. The district covers approximately 2 211 sq.km of which 75% is arable land. The cool climate due to high altitudes makes the district renown for higher rainfalls which favour evergreen thick vegetation which is a potential source of plant medicine. Moreover, the District is one of the densely populated areas in Tanzania recorded to have 371 451 people in 2015 with 168 per sq.km (Mbeya Region, 2016). One of the reasons for high population is the availability of plenty food. When not well managed, high population can have impacts on the utilization of resources including medicinal plants. The HIV/AIDS status of the District presumes for authentic source of data for the scientific documentation of medicinal plants often used in managing HIV/AIDS opportunistic infections. It is for this reason, Rungwe District was chosen. The District is recorded with HIV prevalence of 11% with 22 251 people living with HIV (UNAIDS, 2014; President’s Emergency Plan for AIDS Relief in Tanzania, PEPFAR/T,2015).
 
 
Field survey
 
This study commenced with a desk review of literature followed by field work where a cross sectional design enabled data to be collected from representative population at a single point in time. Cross section designs are popular in collecting information related to practices, attitudes, knowledge and beliefs of a certain population (Mann, 2003; Carlson and Morrison, 2009). The main respondents for this study involved people living with HIV/AIDS from seven purposively sampled villages located adjacent to Mount Rungwe Nature Reserve and Poroto Forest Reserve. The respondents were obtained through snowball techniques as these are effective in recruiting hidden populations such as the HIV patients (Voicu and Babonea, 2007; Barirega et al., 2012). A total of 193 people living with HIV/AIDS were interviewed after informed consents being obtained from respondents. Semi- structured questionnaires were used to gather quantitative data. The information collected included: commonly known plants used to manage HIV/AIDS OIs, specific infections treated, their local or common names, parts used and other related information. Similar information was collected from key informants.
 
Specimen identification
 
Preliminary identification of species was done in the field by using manuals and unidentified specimens were identified using herbarium materials, expert and taxonomic keys found in the volumes of the flora of Tanzania. The collected specimens with voucher numbers, family names, species and vernacular names, dates and collection sites were recorded and deposited at the University of Dar es Salaam herbarium.
 
Data analysis
 
The data were organised and analysed by using Microsoft Excel spreadsheet software, through which computations of proportions on plant species used, plant part (s) used and categories of infections managed were achieved.
 
Fidelity level
 
 
Of equal importance is the fidelity level (FL) which reveals quality, reliability or loyalty of the medicinal plant species. Through fidelity level calculations the relative healing ability of the identified medicinal plants is determined (Friedman et al.,1986). Studies that have adopted this approach include; Giday et al. (2010), Ugulu (2012), Abera (2014) and Parthiban et al. (2016). The fidelity level (FL) is defined as the ratio of the number of informants who independently suggested the use of a species for the same major purpose and the total number of informants who mentioned the plant for any other use. In the FL, Np is the number of informants who reported the use of a plant species to treat a particular disease, and N is the number of informants who used the plants as a medicine to treat any given disease (Friedman et al., 1986);

The highest FL (=100) indicates that a species manages the major disease equally with other ailments and vice versa.
 
Distribution of medicinal plants knowledge among the respondents
 
The collected ethnobotanical data with regards to distribution of medicinal plants knowledge based on socio-demographic characteristics were summarized using descriptive and inferential statistics. The presence or absence of significant differences among the variables was computed using the binary logit model because the dependent variables were categorical. The rationale for choosing this model relies on its suitability in cross-sectional data analysis as confirmed by Cramer (2003). In the binary case, some event Y either occurs (Y =1) or not(Y =0). This model was specified as;
 
 
Where z is the dependent variable or slope parameters and Xs are independent variables influencing z whereas bs are slope coefficients.


 RESULTS

Identified medicinal plant species used to manage HIV/AIDS opportunistic infections
 
This study revealed a total of 31 plant species distributed among 23 families to be used for medicinal purposes particularly in managing HIV/AIDS opportunistic infections in Rungwe District (Table 1). The mostly used families involved: Compositae and Rosaceae by 15% each. These were followed by Amaryllidaceae, Leguminosae, Musaceae and Myrtaceae by 10% each (Figure 2). Some plant species have the ability to deal with multiple ailments, this study exposed four plants among the total identified medicinal plant species to be useful in managing four or more HIV/AIDS related conditions. The list includes; Conyza bonariensis (Compositae) which was mentioned to be potential in managing all six infections that were set as case studies in this study.
 
 
 
 
Those mentioned that deal with four ailments include Berberis holstii (Berberidaceae), Dissotis phaeotricha (Melastomataceae) and Myricia salicifolia (Myricaceae). The fidelity values are given in Table 1. With regards to plant parts extracted for medicine, the mostly used plant parts (s) were leaves (44%) and roots (28%). While bark (s) was used by 7%, fruits, seeds and stem were equally used at 5%. The least used plant parts found in this study were tubers and whole plant by 4% and 2% respectively (Figure 3). Moreover, the proportions of medicinal plant species which are known for managing specific HIV/AIDS opportunistic infections included: Tuberculosis (60%), Herpes simplex (50%), chronic cough (45%), chronic diarrhea (40%), Oral candidiasis (35%) and Herpes zoster (30%) (Figure 4).
 
 
 
 
 


 DISCUSSION

HIV/AIDS is still a major health problem in Tanzania. Medical practitioners are struggling to invent a cure for the pandemic, but with little success, as a result, traditional medicine continues to gain popularity. The popularity attached to traditional medicinal plants especially in managing HIV/AIDS-related infections has prompted for this study which enabled documentation of plant species that are known to be useful in the management of the HIV/AIDS associated infections. Considering plant families, Compositae and Rosaceae, Amaryllidaceae, Leguminosae, Musaceae and Myrtaceae were revealed as the most sources of medicinal plant species in managing HIV/AIDS opportunistic infections. The relative high uses of the surveyed species are attributed to their healing potentialities. Similar to this study, Kisangau et al. (2007)identified Myrtaceae as one of the predominant plant families used in managing HIV/AIDS opportunistic infections. Differently, Chinsembu and Hedimbi (2010)found Combretaceae, Anacardiaceae, Mimosaceae and Ebanaceae as the most used plant families in the management of the HIV/AIDS opportunistic infections.
 
The difference demonstrated in plant families’ use across areas signifies the reliance of medicinal plants on indigenous knowledge for identification. Indigenous knowledge is context based hence, extensive documentations of medicinal plant
species is crucial. The popular use of leaves and roots for medicine preparations correspond with the report by Chinsembu and Hedimbi (2010). Further, a more recent study in Zambia, confirms leaves being the most used plant parts in making medicine for managing HIV/AIDS opportunistic infections (Chinsembu, 2016). More studies with similar findings include: Giday et al. (2010), Otang et al. (2012) and Nankaya (2014). The relative high use of leaves could probably be due to the fact that they are easily to be found and collected over a long period of time. Moreover, people know that plucking leaves of the plant selectively ensures conservation of the plant. On the contrary, a conservation implication of the plants which the most used parts or the most extracted part (s) for medicines are their roots the sustainability of the plants remains uncertain.
 
With regards to tuberculosis consuming most of the plants indicates its prevalence among the HIV/AIDS patients in the study area. A close study by Kisangau et al. (2007) reported the highest percentage of plant species used to manage TB by Haya traditional practitioners. Other studies which revealed TB among the infections consuming largest percent of species include those of: Orwa et al. (2008), Singh et al. (2008), Gutiérrez et al. (2009), Amri and Kisangau (2012), Stackpole et al. (2013), Maana et al. (2014), Amuka et al. (2014), Gebeyehu et al. (2014),Cascaes et al. (2015) and Silva et al. (2015). Moreover, Herpes simplex was managed by many plant species by communities in Rungwe District. For example Ricinus communis species is used in managing herpes simplex and studies elsewhere report its usage in managing body itchy (Agisho et al., 2014). Body itch can be related to herpes simplex. Chronic cough is another reported as common opportunistic infection among people living with HIV/AIDS. Similar to this study, there are evidences of some medicinal products found to manage chronic coughs, they involve; Psidium guajava (Chinsembu and Hedimbi, 2010)in Namibia, and Myricia salicifolia (Kariuki et al., 2014; Kigen et al., 2014) in Kenya.
 
Oral candidiasis was among the lowest in the list of opportunistic infections that was managed using few medicinal plants. The reason for few medicinal plant species use for oral candidiasis may imply that it is not common in the area and so the traditional practitioners have not been able to identify many species for the infection. Moreover, limited species that are known to manage herpes zoster as revealed in the study may be due to its complex features in relation to managements. As reported in other studies, Aloe species were frequently cited to be used in the purpose of managing the infection (Chinsembu and Hedimbi, 2010). With regards to Conyza bonariensis, the plant contributes much in the health care as it was cited to be useful across all the cited HIV/AIDS opportunisticinfections. The plant has a support in literature to indicate that a single plant species can be used to manage more than one infection. This is termed as broad spectrum use of the plant (Chinsembu and Hedimbi, 2010).
 
Generally, the respondents’ recognition of most species in managing HIV/AIDS opportunistic infections for example, Zingiber officinale indicates importance of the species in disease management. Close related results were revealed in North-West Cameroon by Noumi and Manga (2011). Also, Sankaranarayanan et al. (2010)associated Z. officinale with chronic cough treatments and P. guajava reported in the present study has been acknowledged in literature to be historical potential in dealing with diarrhea cases elsewhere for example in Nigeria (Famuyide et al., 2013), diarrhea and tuberculosis (Kisangau et al., 2011), diarrhea (Hazarika et al., 2015). The fact that medicinal plants are being used for the same function by more than one community might be a sign of their pharmacological effectiveness (Giday et al., 2010). The medicinal plants Dissotis phaeotricha (used against Chronic diarrhea), Berberis holstii (used against Tuberculosis) and Aloe spp. (used against skin related infections) indicated highest fidelity level values. According toTrotter and Logan (1986), plants which are used in some repetitive manner are more likely to be biologically active. Berberis holstii has been cited to be useful in managing various diseases (Maliwichi-Nyirenda et al., 2011; Srivastava et al., 2015).
 
Aloe spp. have been reported for their miracles in healing various diseases in different areas (Verma et al., 2015).  Analytically, the knowledge on medicinal plants that manage HIV/AIDS opportunistic infections was independent of sex and age categories of a respondent. It was expected that the level of knowledge would vary among the respondents as it has been found in other studies such as Giday et al. (2010), but it was not the case in this study (Table 2). This could probably be because the interviewees fell under homogenous sample (HIV patients) hence they possess almost the same experience. Likewise the level of knowledge on medicinal plants among the respondents does not depend on primary education because knowledge on medicinal plants is mostly obtained outside classroom. Therefore, ethnobotanical knowledge is normally acquired through experience verbally and traditionally, elders passing the knowledge to younger generation (Absolon, 2010).
 
 
Origin of people can have an impact on knowledge. For instance the Kinga for this case have less knowledge on the list of medicinal plants that manage opportunistic infections compared to the Nyakyusa. The difference was attributed by being not Rungwe natives rather immigrants from another part of the District. The same was found by Pouliot (2011)in her study. The likelihood of knowing medicinal plants that manage opportunistic infections for respondents in Ibumba village was high, but this was by chance because Ibumba is not the only village closest to the forest, rather there are other villages like Syukula and Ngumbulu which are found at the foot of the mountain forest. Chance events may have influence on knowledge of respondents as disclosed by Byg et al. (2010).


 CONCLUSION

The community in Rungwe District is knowledgeable on ethnobotanical knowledge especially on those used to manage HIV/AIDS opportunistic infections. The people’s knowledge was exhibited among other things, and their ability to identify multiple uses of medicinal plants which confirms broad-spectrum of antimicrobial agents of the species. The information by this study adds up to the existing ethnobotanical body of knowledge. Also, it forms a base for future discovery of novel drugs to fight HIV/AIDS related infections along with a need to prove safety and efficacy of medicinal plants hence, building confidence to medicinal plant users. The study recommends more studies on identification and documentation of species potential for managing HIV/AIDS opportunistic infections.


 CONFLICT OF INTERESTS

The authors have not declared any conflict of interests.


 ACKNOWLEDGEMENTS

The authors appreciate the Carnegie Regional Initiative in Science Education- African Natural Products Network (CR-AFNNET) for financial support which facilitated execution of this study. The authors are also highly indebted to the Rungwe district Council officers, District medical officers, forest officers in Rungwe district, local government leaders, local people, traditional practitioners and all other informants consulted, for their hospitality, advice, guidance and cooperation during this study.



 REFERENCES

Abera B (2014). Medicinal plants used in traditional medicine by Oromo people, Ghimbi District, Southwest Ethiopia. J. Ethnobiol. Ethnomed. 10(1):1-15.
Crossref

 

Absolon K (2010). Indigenous wholistic theory: A knowledge set for practice. First Peoples Child Fam. Rev. 5(2):74-87.

 
 

Agisho H, Osie M, Lambore T (2014). Traditional medicinal plants utilization, management and threats in Hadiya Zone, Ethiopia. J. Med. Plant 2(2):94-108.

 
 

Amri E, Kisangau DP (2012). Ethnomedicinal study of plants used in villages around Kimboza forest reserve in Morogoro, Tanzania. J. Ethnobiol. Ethnomed. 8(1):1.
Crossref

 
 

Amuka O, Mbugua PK, Okemo PO (2014). Ethnobotanical survey of selected medicinal plants used by the Ogiek communities in Kenya against microbial infections. Ethnobot. Res. Appl. 12:627-641.
Crossref

 
 

Byg A, Salick J, Law W (2010). Medicinal plant knowledge among lay people in five eastern Tibet villages. Hum. Ecol. 38(2):177-191.
Crossref

 
 

Barirega A, Agea JG, Damme PV (2012). Prioritizing Wild Medicinal and Food Plants with Potential for Commercialization and Value Chain Improvement for Livelihood Enhancement and Poverty Reduction in Uganda. Res. J. Environ. Earth Sci. 4(6):678-683.

 
 

Bukuluki P, Luwangula R, Walakira EJ (2014). Harvesting of Medicinal Plants in Uganda : Practices, Conservation and Implications for Sustainability of Supplies. Int. J. Med. Plant Res. 3(1):1-10.

 
 

Carlson MD, Morrison RS (2009). Study design, precision, and validity in observational studies. J. Palliat. Med. 12(1):77-82.
Crossref

 
 

Cascaes MM, Guilhon GM, Andrade EH, Zoghbi MD, Santos LD (2015). Constituents and pharmacological activities of Myrcia (Myrtaceae): A review of an aromatic and medicinal group of plants. Int. J. Mol. Sci. 16(10):23881-23904.
Crossref

 
 

Chinsembu KC (2016). Ethnobotanical Study of Plants Used in the Management of HIV / AIDS-Related Diseases in Livingstone, Southern Province, Zambia. Evid-Based Complement. Altern. Med.1:1-14.

 
 

Chinsembu KC, Hedimbi M (2010). An ethnobotanical survey of plants used to manage HIV/AIDS opportunistic infections in Katima Mulilo, Caprivi region, Namibia. J. Ethnobio. Ethnomed. 6(1):25.
Crossref

 
 

Cox DR (1958). The regression analysis of binary sequences. J. R. Stat. Soc. Series B (Methodological). 20(2):215-242.

 
 

Cramer JS (2003). The origins and development of the logit model. Logit models from economics and other fields, pp. 1-19.
Crossref

 
 

Ekor M (2014). The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Front. Pharmacol. 4:177.
Crossref

 
 

Famuyide OO, Adebayo O, Bolaji-Olutunji KA, Awe F, Owoeye AY, Awodele DO, Adeyemo A (2013). Assessment and sustainable management of non-timber forest products used as food and medicine among urban dwellers in Oyo State, Nigeria. J. Hort. For. 5(11):186-193.

 
 

Friedman J, Yaniv Z, Dafni APD (1986). A preliminary classification of the healing potential of medicinal plants, based on the rational analysis of an ethnopharmacological field among Bedouins in Negev Desert, Israel. J. Ethnopharmacol. 16:275-287.
Crossref

 
 

Kigen G, Some F, Kibosia J, Rono H, Kiprop E (2014). Ethnomedicinal Plants Traditionally Used by the Keiyo Community in Elgeyo Marakwet County, Kenya. J. Biodivers. Biopros. Dev. 1(132):2-11.

 
 

Gebeyehu G, Asfaw Z, Enyew A, Raja N (2014). Ethnobotanical study of traditional medicinal plants and their conservation status in Mecha Wereda. Int. J. Pharm. Health Care Res. 2(3):137-153.

 
 

Giday M, Asfaw Z, Woldu Z (2010). Ethnomedicinal study of plants used by Sheko ethnic group of Ethiopia. J. Ethnopharmacol. 132(1):75-85.
Crossref

 
 

Hazarika P, Kakati N, Kalita RK (2015). Indigenous knowledge in relation to conservation and management of forest biodiversity of Assam. Life Sci. Leafl. 63:64-93.

 
 

Kariuki DK, Miaron JO, Mugweru J, Kerubo LO (2014). Antibacterial activity of five medicinal plant extracts used by the Maasai people of Kenya. Int. J. Hum. Arts Med. Sci. 2(7):1-6.

 
 

Kisangau DP, Lyaruu HVM, Hosea KM, Joseph CC (2007). Use of traditional medicines in the management of HIV/AIDS opportunistic infections in Tanzania: A case in the Bukoba rural district. J. Ethnobiol. Ethnomed. 3(1):29.
Crossref

 
 

Kisangau DP, Thora Martina Herrmann, Lyaruu HVM, Hosea KM, Joseph CC, Masimba ZH (2011). Traditional Knowledge, Use Practices and Conservation of Medicinal Plants for HIV/AIDS Care in Rural Tanzania. Ethnobot. J. 9:43-57.
Crossref

 
 

Moshi MJ, Innocent E, Magadula JJ, Otieno DF, Nondo RS (2010). Brine shrimp toxicity of some plants used as traditional medicines in Kagera Region, North western Tanzania. Tanzan. J. Health Res.12(1):63-67.
Crossref

 
 

Maana TN, Karachi M, Cheboi E (2014). A rewiew of traditional knowledge, usage and status of the medicinal trees amongst the Tugens of Eldama ravine and Esageri divisions, Koibatek county, Kenya. J. Health Med. Nurs. 5:113-128.

 
 

Magadula JJ, Innocent E, Mbwambo ZH, Kapingu MC (2014). Pytochemical and Pharmacological Studies of some Medicinal Plants from Tanzania. Int. J. Curr. Res. Acad. Rev. 2(10):99-111.

 
 

Mahwasane ST, Middleton L, Boaduo N (2013). An ethnobotanical survey of indigenous knowledge on medicinal plants used by the traditional healers of the Lwamondo area, Limpopo province, South Africa. South Afr. J. Bot. 88:69-75.
Crossref

 
 

Maliwichi-Nyirenda CP, Maliwichi LL, Franco M (2011). Medicinal uses of Berberis holstii Engl.(Berberidaceae) in Malawi, the only African endemic barberry. J. Med. Plants Res. 5(8):1367-1373.

 
 

Mann CJ (2003). Observational research methods. Research design II: cohort, cross sectional, and case-control studies. Emerg. Med. J. 20(1):54-60.
Crossref

 
 

Mbeya Region (2016). Mbeya Regional Secretariat, 2016 and National Bureau of Statistics 2012 Available at: http://www.citypopulation.de/php/tanzania-admin.php?adm1id=12

 
 

Mustapha AA (2014). Ethnobotanical field survey of medicinal plants used by traditional medicine practitioners to manage HIV/AIDS opportunistic infections and their prophylaxis in Keffi Metropolis, Nigeria. Asian J. Plant Sci. Res. 4(1):7-14.

 
 

National AIDS Control Programme (NACP) (2016). HIV and AIDS in Tanzania, UNAIDS Global progress report. Available at: http://www.unaids.org/sites/default/files/media_asset/global-AIDS-update-2016_en.pdf.

 
 

Nankaya JS (2014). The salient traditional medicinal plants and conservation strategies of the Loita Maasai of Kenya (Doctoral dissertation, Clemson University). Available at: 

View

 
 

Noumi E, Manga PN (2011). Traditional Medicines for HIV / AIDS and Opportunistic Infections in North-West Cameroon: Case of Skin Infections. Am. J. Trop. Med. Hyg. 1(3):44-64.

 
 

Omolo JJ, Maharaj V, Naidoo D, Malebo HM, Mtullu S, Lyaruu HV (2014). Flavonoids of Steganotaenia araliacea. Am. J. Res. Community 2(8):52-60.

 
 

Orwa JA, Jondiko IJO, Minja RJ, Bekunda M (2008). The use of Toddalia asiatica (L) Lam. (Rutaceae) in traditional medicine practice in East Africa. J. Ethnopharmacol. 115:257-262.
Crossref

 
 

Otang WM, Grierson DS, Ndip RN (2012). Ethnobotanical survey of medicinal plants used in the management of opportunistic fungal infections in HIV/AIDS patients in the Amathole District of the Eastern Cape Province, South Africa. J. Med. Plants Res. 6(11):2071-2080.

 
 

Parthiban R, Vijayakumar S, Prabhu S, Gnanaselvam J, Morvin E (2016). Quantitative traditional knowledge of medicinal plants used to treat livestock diseases from Kudavasal taluk of Thiruvarur district, Tamil. Rev. Bras. Farmacogn. 26(1):109-121.
Crossref

 
 

President's Emergency Plan for AIDS Relief in Tanzania (PEPFAR/T, 2015). Tanzania Country Operation Plan 2015: Strategic Direction Summary. Available at: https://www.pepfar.gov/countries/cop/c69471.htm

 
 

Pouliot M (2011). Relying on nature's pharmacy in rural Burkina Faso: Empirical evidence of the determinants of traditional medicine consumption. Soc. Sci. Med. 73(10):1498-1507.
Crossref

 
 

Gutiérrez RM, Mitchell S, Solis RV (2009). Psidium guajava: A review of its traditional uses, phytochemistry and pharmacology. J. Ethnopharmacol. 117(1):1-27.
Crossref

 
 

Runyoro DK, Ngassapa OD, Matee MI, Joseph CC, Moshi MJ (2006). Medicinal plants used by Tanzanian traditional healers in the management of Candida infections. J. Ethnopharmacol. 106(2):158-165.
Crossref

 
 

Sankaranarayanan S, Bama P, Ramachandran J, Kalaichelvan PT, Deccaraman M (2010). Ethnobotanical study of medicinal plants used by traditional users in Villupuram district of Tamil Nadu, India. J. Med. Plants Res. 4(12):1089-1101.

 
 

Srivastava S, Srivastava M, Misra A, Pandey G, Rawat A (2015). A review on biological and chemical diversity in Berberis (Berberidaceae). Excli J. 14:247-267.

 
 

Singh RV, Singh P, Hansen LA, Graudal LOV (2008). Medicinal plants, their conservation, use and production in southern India. Forest & Landscape, University of Copenhagen. Available at: http://curis.ku.dk/ws/files/20573315/de11.pdf

 
 

Silva BJ, Seca AM, Barreto C (2015). Recent Breakthroughs in the Antioxidant and Anti-Inflammatory Effects of Morella and Myrica Species. Int. J. Mol. Sci. 16(8):17160-17180.
Crossref

 
 

Trotter RT, Logan MH (1986). Informants consensus: a new approach for identifying potentially effective medicinal plants," in Plants in Indigenous Medicine and Diet. Bedford Hill: Redgrave Publishing Company, Bedford Hill, NY, USA, pp. 91-112.

 
 

Ugulu I (2012). Fidelity level and knowledge of medicinal plants used to make therapeutic Turkish baths. Ethnobot. Med. 6(1):1-9.
Crossref

 
 

United Nations Programme on HIV and AIDS (UNAIDS) (1998). HIV-related opportunistic diseases technical update at a glance.

 
 

United Republic of Tanzania (URT) (2014). Developing estimates of HIV prevalence and the number of people.

 
 

Verma AC, Hingora I, Namratadubey S (2015). Identification and Traditional Uses of Certain Medicinal Plants and Its Conservation In Kawardha area, Chhattisgarh State, India. J. Environ. Sci. Toxicol. Food Technol. 1(1):6-20.

 
 

Voicu MC, Babonea A (2011). Using the snowball method in marketing research on hidden populations. CKS-Challenges of the Knowledge. P 1341.

 
 

World Health Organization (WHO) (2013). Traditional Medicine Strategy.

 
 

Yineger H, Kelbessa E, Bekele T, Lulekal E (2007). Ethno veterinary medicinal plants at Bale Mountains National Park, Ethiopia. J. Ethnopharmacol. 112(1):55-70.
Crossref

 
 

Zhou S (2015). Editorial for Special Issue on Herbal Medicines and Natural Products. Medicines 2:328-330.
Crossref

 

 




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