Boscia senegalensis and Tapinanthus dodoneifolius are two plants mostly used by herders to treat animal diseases in the Far North Region of Cameroon. To evaluate the in vitro antibacterial, cytotoxic and antioxidant potentials of these plants. To achieve this, five extracts (water, methanol, chloroform and hexane) of both plants obtained by successive fractionation were used. Antibacterial activities of the different extracts were evaluated against three bacterial reference strains including Gram-positive (Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli and Salmonella typhi) using agar disc diffusion and broth dilution method. Human colon cancer cells were used to screen their toxicity. 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and ferrous ion chelating assays have been used to investigate the antioxidant activities of the best extract of each plant after the previous analysis.A non-negligible inhibitory effect was observed against S. aureus with hexane extract of B. senegalensis and methanolic extract of T. dodoneifolius. In addition to this property, both plants were classified into the group of inactive plants according to the cytotoxic activity of their extracts. The hexane and methanolic extracts of B. senegalensis and T. dodoneifolius respectively showed a higher antioxidant activities but the hexane extract demonstrate a strong hydrogen donating ability or the electron transfer reaction in comparison to vitamin c used as standard.It can be assume that the antioxidant activity of these plants could contribute to their biological properties and their non-cytotoxic effect assure their safety. Keywords: Antibacterial, Cytotoxic, Antioxidant, Boscia senegalensis, Tapinanthus dodoneifolius

Keywords: Antibacterial, Cytotoxic, Antioxidant, Boscia senegalensis, Tapinanthus dodoneifolius