Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3704

Article in Press

Evaluation of the wound healing properties of methanolic bark extract of Samadera indica Gaertner in vivo

Rama Bhat, P.

  •  Received: 05 July 2018
  •  Accepted: 13 August 2018
In the present study, bark samples of Samadera indica were collected, allowed to shade dry for a week, then coarsely powdered and was extracted with methanol by soxhlation process. The extract was used for wound healing experiment. In the wound healing study using excision wound model, 18 healthy Albino rats of four each with average body weight of 150-200 g was selected randomly for the study, which will be divided into 3 groups of 6 rats each. ANOVA was used to compare the variation in the treatments in the result. The 1st group of animals are left as such for natural healing process as control, 2nd group of animals were treated with standard ointment betadien and 3rd group with the test drug methanolic bark ointment formulation. The methanolic extract in simple ointment base as mentioned above and betadien ointment were applied on the wound once a day for 16 days starting from the day of wounding. The percentage wound closure was observed on 4th, 8th, 12th and 16th post wounding day. As for the group received methanolic bark extract for wound healing, fourth day wound mean diameter was 208.0±3.521, 8th day the wound mean diameter was 160.66±7.89, 12th day wound mean diameter was 87.5±5.8 and 16th day wound mean diameter was 22.5±5.12. Thus there was marked decrease in wound diameter with every point of time the observation made indicating the effect of extract on progressive healing of wound. Comparing to standard drug betadien the bark extract showed faster healing in terms of diameter of wound which was statistically signified. Samadera indica proved its wound healing potential of the plant extract which is due to the bioactive compounds and thus the study supports local folklore practitioners and tribal people for the use of plant in different ailments. Key words: Samadera india, wound healing, albino rats, methanol extract

Keywords: Samadera india, wound healing, albino rats, methanol extract