Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3753

Article in Press

Formulation and evaluation of chewing gums containing natural products on salivary concentrations of Streptococcus mutans in children

Edmir Geraldo de Siqueira Fraga, Edilson Martins Rodrigues Neto*, Fernanda Maria Teófilo Campos, Manoel Patrick da Silva Cavalcante; Frederico Augusto Amorim, Luiz Filipe Barbosa Martins, Antônia Kelly Martins Sousa and Marcelo Jenné Mimica

  •  Received: 10 April 2021
  •  Accepted: 13 September 2021
Oral health has been recognized as a fundamental part of general health, involving biopsychosocial aspects. Streptococcus mutans are the main cariogenic markers related to bacterial biofilm involved in the appearance and progression of childhood caries, having the effect of demineralizing tooth enamel. The alarming incidence of caries in childhood, 5 to 12 years old, is mostly related to sugar consumption like sugary treats. The pharmaceutical and clinical development of a formulation composed of recognized potent natural antimicrobial agents, such as red propolis and xylitol would be an alternative. It is a randomized clinical trial, placebo-controlled, transversal. The research evinced the action of chewable tablets based on Placebo (group I), Red Propolis 2.5% (group II); Red Propolis 6.4% (group III), and Xylitol 15% (group IV). Strictly obeying the criteria of this study, 40 volunteers were selected, who had saliva collected in different moments of the trial for formulations antimicrobial action analysis, under microbiological studies. In group I there were variations before and after the administration of the tablets, but no statistical significance, it was found the group II a significant reduction in the salivary concentration of S. mutans in all salivary dilutions (34,25% - 63,65%) was found, a fact observed with group III (38,42% - 45,02%) and group IV (50,72% - 42,92%). The perspective of new studies arises for the longitudinal evaluation of these pharmaceutical formulations composed of natural bioactive, demonstrating an excellent anti-cariogenic potential and by low cost.

Keywords: chewable tablets, red propolis, xylitol, natural bioactive, Streptococcus mutans