Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3704

Article in Press

Pharmaceutical topical gel containing proanthocyanidin polymers-rich fraction from Stryphnodendron adstringens

Marco Antonio Costa, Andressa Blainski, Vanessa Kaplum, Marli Miriam de Souza Lima, Tânia Ueda-Nakamura, Benedito Prado Dias Filho, João Carlos Palazzo de Mello and Celso Vataru Nakamura*

The stem bark of Stryphnodendron adstringens, popularly known in Brazil as "barbatimão", has many biological activities, including antifungal activity. Considering the increasing interest of using "barbatimão" extract in the treatment of vaginal candidiasis, the aim of this study was to propose a pharmaceutical topical gel containing a proanthocyanidin polymers-rich fraction for use as a pharmacological agent in vaginal gels, as well as to evaluate the validation parameters for the determination of phenolic compounds. UV/Vis spectrophotometry was used as a quantitative method for quality control of topical gel and a proanthocyanidin polymers-rich fraction was used in this work. The proposed gel seems suitable for use in vaginal infections, and the analytical method was linear, specific, precise, accurate, reproducible and robust. This methodology complies with analytical application demands and it is easily performed in work routine.

Keywords: Barbatimão, polyphenols, Stryphnodendron adstringens, UV/Vis spectrophotometry, vaginal gel, validation method.