Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3627

Full Length Research Paper

Evaluation of the in vivo antiplasmodial activity of ethanol leaf extract and fractions of Jatropha gossypifolia in Plasmodium berghei infected mice

Onyegbule F. A.
  • Onyegbule F. A.
  • Department Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Nigeria.
  • Google Scholar
Bruce S. O.
  • Bruce S. O.
  • Department of Pharmacognosy and Traditional Medicine, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Nigeria.
  • Google Scholar
Onyekwe O. N.
  • Onyekwe O. N.
  • Department of Pharmacognosy and Traditional Medicine, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Nigeria.
  • Google Scholar
Onyealisi O. L.
  • Onyealisi O. L.
  • Department of Pharmacognosy and Traditional Medicine, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Nigeria.
  • Google Scholar
Okoye P. C.
  • Okoye P. C.
  • Department of Pharmacognosy and Traditional Medicine, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Nigeria.
  • Google Scholar


  •  Received: 31 March 2019
  •  Accepted: 10 May 2019
  •  Published: 10 June 2019

References

Abbiw DK (1990). Useful plants of Ghana: West African uses of wild and cultivated plants. Intermediate Technology Publications. London and Royal Botanic Gardens, Kew, Richmond, United Kingdom P 337.
Crossref

 

Abreu IC, Marinho AS, Paes AM, Freire SM, Olea RS, Borges MO, Borges AC (2003). Hypotensive and vasorelaxant effects of ethanolic extract from Jatropha gossypifolia L. in rats. Fitoterapia 74(7-8):650-657.
Crossref

 

Adebayo JO, Krettli AU (2011). Potential antimalarials from Nigerian plants: A review. Journal of Ethnopharmacology 133:289-302.
Crossref

 

Adebayo JO, Santana AE, Krettli AU (2012). Evaluation of the antiplasmodial and cytotoxicity potentials of husk fiber extracts from Cocos nucifera, a medicinal plant used in Nigeria to treat human malaria. Human and Experimental Toxicology 31:244-249.
Crossref

 

Ali AJ, Usman TA, Martins NE (2011). In-vivo antimalarial and toxicological evaluation of Chrozophora senegalensis A. Juss (euphorbiaceae) extracts. Journal of Applied Pharmaceutical Science 1(10):90-94.

 

Apu AS, Ireen K, Hossan BS (2012). Evaluation of analgesic, neuropharmacological and anti-diarrheal potential of Jatropha gossypifolia (Linn) leaves in mice. Journal of Medical Sciences 12(8):274-279.
Crossref

 

Beare NA, Lewallen S, Taylor TE, Molyneux ME (2011). Redefining cerebral malaria by including malaria retinopathy. Future Microbiology 6(3):349-55.
Crossref

 

Bhagat R, Ambavade SD, Misar AV, Kulkarni DK (2011). Anti-inflammatory activity of Jatropha gossypifolia L. leaves in albino mice and Wistar rat. Journal of Scientific and Industrial Research 70(4):289-292.

 

British Pharmacopoeia (2011). Azadirachta indica A. Juss. leaves. Volume iv; incorporating the requirements of the 6th edition of the European Pharmacopoeia as amended by supplements 6.1 to 6.8. Northern Ireland. Pp 3398-99.

 

Bruce SO, Onyegbule FA, Ihekwereme CP (2016). Evaluation of the hepato-protective and anti-bacterial activities of ethanol extract of Picralima nitida seed and Pod. Journal of Phytomedicine and Therapeutic 15(2):1-21.

 

Caraballo H (2014). Emergency department management of mosquito-borne illness: Malaria, dengue, and west Nile virus. Emergency Medicine Practice 16(5):1-23.

 

Csurhes SM (1999). Bellyache bush (Jatropha gossypifolia) in Queensland. Pest Status Review Series - Land Protection, Department of Natural Resources and Mines, Brisbane, Queensland, Australia. P 38. 

View

 

Ezenwa CJ, Onyegbule FA, Umeokoli BO, Osonwa UE (2017). Antiplasmodial evaluation of methanol leaf extract and fractions of Chrysophyllum albidum G. Don (Sapotaceae). Asian Journal of Biomed Pharmaceutical Science 7(61):35-41. 

View

 

Ezugwu CO, Odoh UE, Ezea SC (2011). Determination of pharmacognostic standards of medicinal plants. Paschal Communications, Nsukka, Enugu, Nigeria pp. 38-47.

 

Ferri FF (2009). Ferri's color atlas and text of clinical medicine: Expert Consult-Online and Print. Elsevier Health Sciences.
Crossref

 

Filler S, Causer LM, Newman RD, Barber AM, Roberts JM, MacArthur J, Parise ME, Steketee RW (2003). Malaria surveillance-United States, 2001. Morbidity and Mortality Weekly Report CDC Surveillance Summaries 52(5).

 

Gollin D, Zimmermann C (2007). Malaria: Disease impacts and long-run income differences.

 

Hartman TK, Rogerson SJ, Fischer PR (2010). The impact of maternal malaria on newborns. Annals of Tropical Pediatrics 30 (4):271-282.
Crossref

 

Hasting IM, D'Alessandro U (2000). Modeling a predictable disaster: the rise and spread of drug-resistant malaria. Parasitology Today 16:340-347.
Crossref

 

Idowu ET, Ajaegbu HCN, Omotayo AI, Aina OO, Otubanjo OA (2015). In vivo anti-plasmodial activities and toxic impacts of lime extract of a combination of Picralima nitida, Alstonia boonei and Gongronema latifolium in mice infected with Chloroquine-sensitive Plasmodium berghei. African Health Sciences 15(4):1262-1270.
Crossref

 

Iyiola OA, Tijani AY, Lateef KM (2011). Antimalarial activity of ethanolic stem bark extract of Alstonia boonei in mice. Asian Journal of Biological Sciences 4:235-243.
Crossref

 

Kharat AR, Dolui AK, Das S (2011). Free radical scavenging potential of Jatropha gossypifolia. Asian Journal of Chemistry 23(2):799-801.

 

Korenromp E, Williams B, De Vlas S, Gouws E, Gilks C, Ghys P, Nahlen B (2005). Malaria is attributable to the HIV-1 epidemic, sub-Saharan Africa. Emerging Infectious Diseases 11 (9):1410-9.
Crossref

 

Kupcan SM, Sigel CW, Matz MJ, Renauld JAS, Haltiwanger RC, Bryan RF (1970). Jatrophone, a novel macro cyclicditerpenoids tumor inhibitor from Jatropha gossypifolia. Journal of the American Chemical Society 92(14):4476-4477.
Crossref

 

Lorke DA (1983). New approach to practical acute toxicity test. Arch Toxicology 54:279-86.
Crossref

 

Murray CJL, Rosenfeld LC, Lim SS, Andrews KG, Foreman KJ, Haring D, Fullman N, Naghavi M, Lozano R, Lopez AD (2012). Global malaria mortality between 1980 and 2010: a systematic analysis. The Lancet 379:413-431.
Crossref

 

Murugalakshmi M, Mari SJ, Vallimail M, Anitha PRJ, Thangapandian V (2014). Preliminary phytochemical analysis of Jatropha gossypifolia. World Journal of Pharmacy and Pharmaceutical Sciences 3 (7):1127-1135.

 

Nadjm B, Behrens RH (2012). Malaria: An update for physicians. Infectious Disease Clinics 26 (2):243-59.
Crossref

 

Nethengwe MF, Opoku AR, Dludla PV, Madida KT, Shonhai A, Smith P, Singh M (2012). Larvicidal, antipyretic and antiplasmodial activity of some Zulu medicinal plants. Journal of Medicinal Plants Research 6(7):1255-1262.
Crossref

 

Ogbe RJ, Adenkola AY, Anefu E (2012). Aqueous ethanolic extract of Mangifera indica stem bark effect on the biochemical and haematological parameters of albino rats. Archives of Applied Science Research 4(4):1618-1622.

 

Taylor WR, Hanson J, Turner GD, White NJ, Dondorp AM (2012). Respiratory manifestations of malaria. Chest 142 (2):492-505.
Crossref

 

Vale JR, Czeczko NG, Aquino JU (2006). Estudo comparativo da cicatrização de gastrorrafias com e sem o uso do extrato de Jatropha gossypiifolia L. (pião roxo) em ratos. Acta Cirúrgica Brasileira, 21(Suplemento 3):1.
Crossref

 

Vijayta S, Renu M, Sikha M, Nishi Y (2015). Analysis of the phytochemical content of Jatropha gossypifolia L. Chemical and Process Engineering Research, Vol.35. ISSN 2224-7467 (Paper) ISSN 2225-0913 (Online).

 

Wikipedia (2009). Jatropha gossypifolia, en.wikipedia.org/wiki/Jatropha_gossypiifolia. Retrieved 2019-05-28.

 

Sofowora A (1993). Medicinal plants and Traditional medicine in Africa. Spectrum Books Ltd, Ibadan, Nigeria pp 289.

 

Trease GE, Evans WC (1989). Pharmacognosy. 13th (ed). ELBS/Bailliere Tindall, London pp. 345-6535