Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3737

Full Length Research Paper

Phytochemical and acute toxicity studies of methanolic extracts of selected antimalarial plants of Nupeland, north central Nigeria

Usman Idris Nda-Umar
  • Usman Idris Nda-Umar
  • Department of Science Laboratory Technology, Federal Polytechnic, P. M. B. 55, Bida, Niger State, Nigeria.
  • Google Scholar
Mohammed Gbate
  • Mohammed Gbate
  • Department of Science Laboratory Technology, Federal Polytechnic, P. M. B. 55, Bida, Niger State, Nigeria.
  • Google Scholar
Abdulkadir Nda Umar
  • Abdulkadir Nda Umar
  • Department of Science Laboratory Technology, Federal Polytechnic, P. M. B. 55, Bida, Niger State, Nigeria.
  • Google Scholar
Yahaya Masaga Alfa
  • Yahaya Masaga Alfa
  • Department of Science Laboratory Technology, Federal Polytechnic, P. M. B. 55, Bida, Niger State, Nigeria.
  • Google Scholar
Abdullahi Mann
  • Abdullahi Mann
  • Department of Chemistry, Federal University of Technology, P. M. B. 65, Minna, Niger State, Nigeria.
  • Google Scholar

  •  Received: 04 April 2017
  •  Accepted: 08 May 2017
  •  Published: 25 May 2017


Adebayo EA, Ishola OR (2009). Phytochemical and antimicrobial screening of crude extracts from the root, stem bark, and leaves of Terminalia glaucescens. Afr. J. Pharm. Pharmacol. 3(5):217-221.


Adumanya OC, Uwakwe AA, Odeghe OB, Onwuka FC, Akaehi HC (2012). The effects of vitamin c and grape fruit juice supplements on the potency and efficacy of some selected anti-malarial drugs. Global J. Res. Med. Plants Indigen. Med. 1(5):164-171.


Anaduaka EG, Ogugua VN, Egba SI, Apeh VO (2013). Investigation of some important phytochemical, nutritional properties and toxicological potentials of ethanol extracts of Newbouldia laevis Leaf and Stem. Afr. J. Biotechnol. 12(40):5846-5854.


Arome D, Chinedu E, Ameh SF, Sunday AI (2016). Comparative antiplasmodial evaluation of Cymbopogon citratus extracts in Plasmodium berghei‑infected mice. J. Curr. Res. Sci. Med. 2(1):29-35.


Chugh CA, Bharti D (2012). Phytochemical analysis and screening of antibacterial activity of some selected Indian medicinal plants. Int. J. Phytomed. 4:261-265.


Cobett JR, Wight K, Baille AC (2003). Biochemical mode of action of pesticides. 2nd ed. Academic Press, London.


Cook MC (1996). Flavonoids-Chemistry, metabolism, cardio, protective effects and dietary sources. Nutr. Biochem. 7:66-76.


Debebe Y, Tefera M, Mekonnen W, Abebe D, Woldekidan S, Abebe A, Belete Y, Menberu T, Belayneh B, Tesfaye B, Nasir I, Yirsaw K, Basha H, Dawit A, Debella A (2015). Evaluation of anthelmintic potential of the ethiopian medicinal plant Embelia schimperi vatke in vivo and in vitro against some intestinal parasites. BMC Complement. Altern. Med. 15:187.


Hilou A, Nacoulma OG, Guiguemde TR (2006). In vivo antimalarial activities of extracts from Amaranthus spinosus L. and Boerhaavia erecta L. in Mice. J. Ethanopharmacol. 103(2):236-240.


Jigam AA, Helmina O, Dauda BEN, Okogun, JO (2010). Polygalloyltannin isolated from the root of Acacia nilotica De l. (Leguminoseae) is effective against Plasmodium berghei in Mice. J. Med. Plants Res. 4(12):1169-1175.


Jimoh FO, Oladiji AT (2005). Preliminary studies on Piliostigma thonningii: preliminary analysis, mineral composition and phytochemical screening. Afr. J. Biotechnol. 4:1439-1442.


Kittakoop P, Mihidol C, Ruchirawat S (2014). Alkaloids as important scaffolds in therapeutic drugs for the treatments of cancer, tuberculosis and smoking cessation. Curr. Top Med. Chem. 14(2):239-255.


Kolodziej H, Kiderlen AF (2005). Antileishmanial activity and immune modulatory effect of tannins and related compounds on leishmania parasitized RAW 264.7 cells. Phytochemistry 66(17):2056-2071.


Latha LS, Reddy PN (2009). Antimicrobial, antidiarrhoeal and analysis of phytochemical constituents of Sphaeranthus amaranthoides. Indian J. Sci. Technol. 2(3):45-48.


Lu L, Liu SW, Jiang SB, Wu SG (2004). Tannin inhibits HIV-1 entry by targeting gp41. Acta Pharmacol. Sin. 25(2):213-8.


Mann A, Gbate M, Umar AN (2003). Medicinal and economic plants of nupeland.1st Edition. Jube-Evans books and publications, Bida, Niger State, Nigeria. pp. 33-121.


Mann A ((2007). Survey of ethnomedicine for the treatment of tuberculosis: Chemistry perspective. Ayanwola printing works, Minna Niger State, Nigeria. P 117.


Nda-Umar UI, Gbate M, Umar AN Mann A (2014). Ethnobotanical study of medicinal plants used for the treatment of malaria in nupeland, North Central Nigeria, Global J. Res. Med. Plants Indigen. Med. 3(4):112-126.


Ndjakou BL, Weniger B, Tantangmo F, Chaabi M, Ngouela S, Tsamo E, Anton R (2006). Antimalarial and antitrypanosomal activities of West Cameroon medicinal plants. Planta Med. 72(11): P008.


Njoku PC, Akumufula MI (2007). Phytochemical and nutrient evaluation of Spondiias mombi Leaves. Pak. J. Nutr. 6(6):613-615.


Neuwinger HD (2000). African traditional medicine: A dictionary of plant use and applications. Medpharm scientific, Stuttgart, Germany. P 589.


Organization of Economic Cooperation and Development (OECD) (2001). Guidelines for the testing of chemicals, 2001. OECD 420. Acute oral toxicity-fixed dose procedure. Paris, France. 


Parekh J, Chanda S (2007). Antibacterial and phytochemical studies on twelve species of Indian medicinal plants. Afr. J. Biomed. Res. 10:175-181.


Sha'a KK, Ajayi, OO, Arong GA (2014). The in vitro antimalarial activity of aqueous and ethanolic extracts of Anacardium occidentale against Plasmodium falciparum in Damboa, North-Eastern Nigeria. Intern. J. Sci. Technol. 4(4):80-85.


Sofowora A (1986). The state of medicinal plants research in Nigeria. University Press, Ibadan, Nigeria.


Swigio G, Tyrakwoska B (2003). Quality of commercial apple juices evaluated on the basis of polyphenol content and TEAC antioxidant activity. J. Food Sci. 68(5):1844-1849.


Titanji VPK, Zofou D, Ngemenya MN (2008). The antimalarial potential of medicinal plants used for the treatment of malaria in Cameroonian folk medicine. Afr. J. Trad. Complement. Altern. Med. 5(3):302-321.


Usman H, Yaro AH, Garba MM (2008). Phytochemical and anticonvulant screening of the ethanolic flower extracts of Newbouldia laevis (Bignoniaceae) in Mice. J. Pharmacol. Toxicol. 3(2):127-133.


World Health Organization (WHO) and United Nation Children's Fund (UNICEF) (2003). The Africa malaria report, 2003. World Health Organization/ United Nations Children's Fund. 


World Health Organization (WHO) (2011). World malaria report, 2011. World Health Organization, Geneva, Switzerland. 


World Health Organization (WHO) (2014). World malaria report, 2014. World Health Organization, Geneva, Switzerland.