Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3843

Full Length Research Paper

Characterization of the bioactive constituents of Nymphaea alba rhizomes and evaluation of anti-biofilm as well as antioxidant and cytotoxic properties

Riham Omar Bakr
  • Riham Omar Bakr
  • Pharmacognosy Department, October University for Modern Sciences and Arts (MSA), Giza, Egypt.
  • Google Scholar
Reham Wasfi
  • Reham Wasfi
  • Microbiology and Immunology Department, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), Giza, Egypt.
  • Google Scholar
Noha Swilam
  • Noha Swilam
  • Pharmacognosy Department, Faculty of Pharmacy, British University in Egypt (BUE), Cairo, Egypt.
  • Google Scholar
Ibrahim Ezz Sallam
  • Ibrahim Ezz Sallam
  • Pharmacognosy Department, October University for Modern Sciences and Arts (MSA), Giza, Egypt.
  • Google Scholar


  •  Received: 29 May 2016
  •  Accepted: 05 July 2016
  •  Published: 10 July 2016

References

Abdelwahed A, Bouhlel I, Skandrani I, Valenti K, Kadri M, Guiraud P, Steiman R, Mariotte AM, Ghedira K, Laporte F, Dijoux-Franca MG, Chekir-Ghedira L (2007). Study of antimutagenic and antioxidant activities of gallic acid and 1,2,3,4,6-pentagalloylglucose from Pistacia lentiscus. Confirmation by microarray expression profiling. Chem. Biol. Interact. 165:1-13.
Crossref

 

Abu-Reidah IM, Arráez-Román D, Segura-Carretero A, Fernández-Gutiérrez A (2013). Extensive characterisation of bioactive phenolic constituents from globe artichoke (Cynara scolymus L.) by HPLC–DAD-ESI-QTOF-MS. Food chem. 141(3):2269-2277.
Crossref

 
 

Archer NK, Mazaitis MJ, Costerton JW, Leid JG, Powers ME, Shirtliff ME (2011). Staphylococcus aureus biofilms: Properties, regulation and roles in human disease. Virulence 2:445-459.
Crossref

 
 

Barry KM, Davies NW, Mohammed CL (2001). Identification of hydrolysable tannins in the reaction zone of Eucalyptus nitens wood by high performance liquid chromatography--electrospray ionisation mass spectrometry. Phytochem. Anal. 12(2):120-127.
Crossref

 
 

Berardini N, Carle R, Schieber A (2004). Characterization of gallotannins and benzophenone derivatives from mango (Mangifera indica L. cv. 'Tommy Atkins') peels, pulp and kernels by high-performance liquid chromatography/electrospray ionization mass spectrometry. Rapid Commun. Mass Spectrum 18:2208-2216.
Crossref

 
 

Bose A, Ray S, Sahoo M (2013). Central depressant activity of ethanol extract of Nymphaea alba rhizome in mice. Orient. Pharm. Exp. Med. 13:159-64.
Crossref

 
 

Bose AS, Moumita SR, Sudhanshu SC (2014). Uterotonic properties of Nymphaea alba on isolated myometrium model. Int. J. Pharm.Pharm. Sci. 6:490-493.

 
 

Bose AS, Ray S (2012a). In vivo evaluation of anti-diarrheal activity of the rhizome of Nymphaea alba (Nymphaeaceae). Orient. Pharm. Exp. Med. 12:129-134.
Crossref

 
 

Bose AS, Sahoo M (2012b). Evaluation of analgesic and antioxidant potential of ethanolic extract of Nymphaea alba rhizome. Oxid. Antioxid. Med. Sci. 1:217-223.
Crossref

 
 

Cantos E, Espín JC, López-Bote C, Ordó-ez JA, Tomás-Barberán FA (2003). Phenolic Compounds and Fatty Acids from Acorns (Quercus spp.), the Main Dietary Constituent of Free-Ranged Iberian Pigs. J. Agric. Food Chem. 51:6248-6255.
Crossref

 
 

Cheesbrough M (2005). District Laboratory Practice in Tropical Countries, 2nd edition, New York, Cambridge University Press.
Crossref

 
 

Dincheva I, Badjakov I, Kondakova V, Dobson P, Mcdougall G, Stewart D (2013). Identification of the phenolic components in Bulgarian raspberry Cultivars by LC-ESI-MS. IJASR 3:127-138.

 
 

Elegami AA, Bates C, GraY AI, Mackay SP, Skellern GG, Waigh RD (2003). Two very unusual macrocyclic flavonoids from the water lily Nymphaea lotus. Phytochemistry 63:727-731.
Crossref

 
 

Fischer UA, Carle R, Kammerer DR (2011). Identification and quantification of phenolic compounds from pomegranate (Punica granatum L.) peel, mesocarp, aril and differently produced juices by HPLC-DAD–ESI/MSn. Food Chem, 127:807-821.
Crossref

 
 

Fotakis G, Timbrell JA (2006). In vitro cytotoxicity assays: comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride. Toxicol. Lett. 160(2):171-177.
Crossref

 
 

Fracassetti D, Costa C, Moulay L, Tomás-Barberán FA (2013). Ellagic acid derivatives, ellagitannins, proanthocyanidins and other phenolics, vitamin C and antioxidant capacity of two powder products from camu-camu fruit (Myrciaria dubia). Food Chem. 139:578-588.
Crossref

 
 

Gilani AH, Rahman AU (2005). Trends in ethnopharmocology. J. Ethnopharmacol. 100:43-49.
Crossref

 
 

Hassaan Y, Handoussa H, El-Khatib AH, Linscheid MW, El Sayed N, Ayoub N (2014). Evaluation of Plant Phenolic Metabolites as a Source of Alzheimer's Drug Leads, BioMed Research International,

 
 

Hossain MB, Rai DK, Brunton NP, Martin-Diana AB, Barry-Ryan C (2010). Characterization of Phenolic Composition in Lamiaceae Spices by LC-ESI-MS/MS. J. Agric. Food Chem. 58:10576-10581.
Crossref

 
 

Huang ST, Wang CY, Yang RC, Wu HT, Yang SH. (2011). Ellagic Acid, the Active Compound of Phyllanthus urinaria, Exerts In Vivo Anti-Angiogenic Effect and Inhibits MMP-2 Activity. Evid. Based. Complement. Alternat. Med. 2011:215035.
Crossref

 
 

Jambor J, Skrzypczak LA (1991). Phenolic acids from the flowers of Nymphaea alba L. Acta Soc. Bot. Pol. 60:127-132.
Crossref

 
 

Jones SM, Morgan M, Humphrey TJ, Lappin-Scott H (2001). Effect of vancomycin and rifampicin on meticillin-resistant Staphylococcus aureus biofilms. Lancet 357:40-41.
Crossref

 
 

Kajdzanoska M, Gjamovski V, Stefova M (2010). HPLC-DAD-ESI-MS Identification of phenolic compounds in cultivated strawberries from Macedonia. Maced. J. Chem. Chem. Eng. 29:181-94.

 
 

Kalaivani T, Rajasekaran C, Mathew L (2011). Free radical scavenging, cytotoxic, and hemolytic activities of an active antioxidant compound ethyl gallate from leaves of Acacia nilotica (L.) Wild. Ex. Delile subsp. indica (Benth.) Brenan. J Food Sci. 76:144-149.
Crossref

 
 

Kang MS, Oh JS, Kang IC, Hong SJ, Choi CH. (2008). Inhibitory effect of methyl gallate and gallic acid on oral bacteria. J. Microbiol. 46:744-750.
Crossref

 
 

Khan N, Sultana S (2005). Inhibition of potassium bromate-induced renal oxidative stress and hyperproliferative response by Nymphaea alba in Wistar rats. J. Enzyme Inhib. Med. Chem. 20:275-283.
Crossref

 
 

Khanbabaee K, Vanree T (2001). Tannins: classification and definition. Nat. Prod. Rep. 18:641-649.
Crossref

 
 

Kim H, Park SH (2009). Metabolic profiling and discrimination of two Cacti cultivated in Korea using HPLC-ESI-MS and multivariate statistical analysis. J. Korean Soc. Appl. Biol. Chem. 52:346-352.
Crossref

 
 

Klancnik A, Piskernik S, Jersek B, Mozina SS. (2010). Evaluation of diffusion and dilution methods to determine the antibacterial activity of plant extracts. J. Microbiol. Methods 81:121-126.
Crossref

 
 

Kosalec I, Bakmaz M, Pepeljnjak S, Vladimir-Knezevic S (2004). Quantitative analysis of the flavonoids in raw propolis from northern Croatia. Acta Pharm. 54:65-72.

 
 

Król E, Desousa A, Dasilva I, Polaquini CR, Regasini LO, Ferreira H, Scheffers D (2015). Antibacterial activity of alkyl gallates is a combination of direct targeting of FtsZ and permeabilization of bacterial membranes. Front. Microbiol. 6:390.
Crossref

 
 

Lee TH, Chiou JL, Lee CK, Kuo YH (2005). Separation and Determination of Chemical Constituents in the Roots of Rhus Javanica L. Var. Roxburghiana. J. Chin. Chem. Soc. 52:833-841.
Crossref

 
 

Li XC, Elsohly HN, Hufford CD, Clark AM (1999). NMR assignments of ellagic acid derivatives. Magn. Reson. Chem. 37:856-859.
Crossref

 
 

Liberal J, Francisco V, Costa G, Figueirinha A, Amaral MT, Marques C, Girão H, Lopes MC, Cruz MT, Batista MT (2014). Bioactivity of Fragaria vesca leaves through inflammation, proteasome and autophagy modulation. J. Ethnopharmacol. 158:113-122.
Crossref

 
 

Martucci MEP, De Vos RCH, Carollo CA, Gobbo-Neto L. (2014). Metabolomics as a Potential Chemotaxonomical Tool: Application in the Genus Vernonia Schreb. PLoS One. 9(4): e93149.
Crossref

 
 

Mena P, Calani L, Asta CD, Galaverna G, García-Viguera C, Bruni R, Crozier A, Del Rio D (2012). Rapid and Comprehensive Evaluation of (Poly)phenolic Compounds in Pomegranate (Punica granatum L.) Juice by UHPLC-MSn. Molecules 17:14821-14840.
Crossref

 
 

Nawwar MAM, Hussein SAM, Merfort I (1994). NMR spectral analysis of polyphenols from Punica granatum. Phytochemistry, 36:793-798.
Crossref

 
 

Nonaka GI, Ishimatsu M, Tanaka T, Nishioka I, Nishizawa M (1987). Tannins and Related Compounds. LVIII.: Novel Gallotannins Possessing an α-Glucose Core from Nuphar japonicum DC.(Organic,Chemical). Chem. Pharm. Bull. 35:3127-3131.
Crossref

 
 

Oh GS, Pae HO, Oh H, Hong SG, Kim IK, Chai KY, Yun YG, Kwon TO, Chung HT (2001). In vitro anti-proliferative effect of 1,2,3,4,6-penta-O-galloyl-beta-D-glucose on human hepatocellular carcinoma cell line, SK-HEP-1 cells. Cancer Lett. 174:17-24.
Crossref

 
 

Oktay M, Gülçin İ, KüfrevioÄŸlu Öİ (2003). Determination of in vitro antioxidant activity of fennel (Foeniculum vulgare) seed extracts. LWT-Food Sci. Technol. 36:263-271.

 
 

Otto M (2009). Staphylococcus epidermidis – the "accidental" pathogen. Nat. Rev. Microbiol. 7:555-567.
Crossref

 
 

Peeters E, Nelis HJ, Coenye T (2008). Resistance of planktonic and biofilm-grown Burkholderia cepacia complex isolates to the transition metal gallium. J. Antimicrob. Chemother. 61:1062-1065.
Crossref

 
 

Pérez-Magari-o S, Revilla I, González-SanJosé ML, Beltrán S (1999). Various applications of liquid chromatography–mass spectrometry to the analysis of phenolic compounds. J. Chromatogr. A. 847:75-81.
Crossref

 
 

Piwowarski JP, Kiss AK (2013). C-glucosidic ellagitannins from Lythri herba (European Pharmacopoeia): Chromatographic profile and structure determination. Phytochem. Anal. 24(4):336-348.
Crossref

 
 

Regueiro J, Sánchez-González C, Vallverdú-Queralt A, Simal-Gándara J, Lamuela-Raventós R, Izquierdo-Pulido M (2014). Comprehensive identification of walnut polyphenols by liquid chromatography coupled to linear ion trap–Orbitrap mass spectrometry. Food Chem. 152:340-348.
Crossref

 
 

Rios JL, Recio MC (2005). Medicinal plants and antimicrobial activity. J. Ethnopharmacol. 100:80-84.
Crossref

 
 

Sauer K, Camper AK (2001). Characterization of phenotypic changes in Pseudomonas putida in response to surface-associated growth. J. Bacteriol. 183:6579-6589.
Crossref

 
 

Saura-Calixto F, Pérez-jiménez J (2009). Tannins: Bioavailability and Mechanisms of Action. Chemoprevention of Cancer and DNA Damage by Dietary Factors. Wiley-VCH Verlag GmbH & Co. KGaA.
Crossref

 
 

Seeram NP, Lee R, Scheuller HS, Heber D (2006). Identification of phenolic compounds in strawberries by liquid chromatography electrospray ionization mass spectroscopy. Food Chem. 97:1-11.
Crossref

 
 

Sellappan S, Akoh CC (2002). Flavonoids and antioxidant capacity of Georgia-Grown Vidalia onions. J. Agric. Food Chem, 50:5338-42.
Crossref

 
 

Sentandreu E, Cerdán-Calero M, Sendra JM (2013). Phenolic profile characterization of pomegranate (Punica granatum) juice by high-performance liquid chromatography with diode array detection coupled to an electrospray ion trap mass analyzer. J. Food Compos. Anal. 30:32-40.
Crossref

 
 

Shibata H, Kondo K, Katsuyama R, Kawazoe K, Sato Y, Murakami K, Takaishi Y, Arakaki N, Higuti T (2005). Alkyl gallates, intensifiers of beta-lactam susceptibility in methicillin-resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 49:549-555.
Crossref

 
 

Shimada K, Fujikawa K, Yahara K, Nakamura T (1992). Antioxidative properties of xanthan on the autooxidation of soybean in cyclodextrin emulsion. J. Agric. Food Chem. 40:945-948.
Crossref

 
 

Simirgiotis MJ (2013). Antioxidant Capacity and HPLC-DAD-MS Profiling of Chilean Peumo (Cryptocarya alba) Fruits and Comparison with German Peumo (Crataegus monogyna) from Southern Chile. Molecules 18:2061-2080.
Crossref

 
 

Sójka M, Guyot S, KoÅ‚odziejczyk K, Król B, Baron A (2009). Composition and properties of purified phenolics preparations obtained from an extract of industrial blackcurrant (Ribes nigrum L.) pomace ISAFRUIT Special Issue. J. Hortic. Sci. Biotechnol. pp. 100-106.
Crossref

 
 

Takai E, Hirano A, Shiraki K (2011). Effects of alkyl chain length of gallate on self-association and membrane binding. J Biochem. 150:165-171.
Crossref

 
 

Tian F, Li B, Ji B, Zhang G, Luo Y (2009). Identification and structure–activity relationship of gallotannins separated from Galla chinensis. LWT - Food Sci. Technol. 42:1289-1295.

 
 

Upadhyay A, Upadhyaya I, Kollanoor-Johny A, Venkitanarayana K (2014). Combating pathogenic microorganisms using plant-derived antimicrobials: a minireview of the mechanistic basis. BioMed Res. Int. 2014:761741.
Crossref

 
 

Valentino MD, Foulston L, Sadaka A, Kos VN, Villet RA, Santamaria JJR., Lazinski DW, Camilli A, Walker S, Hooper DC, Gilmore MS (2014). Genes contributing to Staphylococcus aureus fitness in abscess- and infection-related ecologies. MBio. 5(5):e01729-14.
Crossref

 
 

Valgas C, Souza SMD, Smânia EFA, Smânia JRA (2007). Screening methods to determine antibacterial activity of natural products. Braz. J. Microbiol. 38:369-380.
Crossref

 
 

Wang CR, Zhou R, Ng TB, Wong JH, Qiao WT, Liu F (2014). First report on isolation of methyl gallate with antioxidant, anti-HIV-1 and HIV-1 enzyme inhibitory activities from a mushroom (Pholiota adiposa). Environ. Toxicol. Pharmacol. 37:626-637.
Crossref

 
 

Wiersema JH (1987). A monograph of Nymphaea subgenus Hydrocallis (Nymphaeaceae). Syst. Bot. Monogr. 16:1-112.
Crossref

 
 

Wilson A (2000). Cytotoxicity and viability assays in animal cell culture: A Practical Approach, 3rd ed., Oxford University Press.

 
 

Wu HY, Lin TK, Kuo HM, Huang YL, Liou CW, Wang PW, Chuang JH (2012). Phyllanthus urinaria Induces Apoptosis in Human Osteosarcoma 143B Cells via Activation of Fas/FasL- and Mitochondria-Mediated Pathways 2012: Article ID 925824. J. Evidence-Based Complementary Altern. Med. 13 p.

 
 

Wyrepkowski CC, Costa DL, Sinhorin AP, Vilegas W, DeGrandis RA, Resende FA, Varanda EA, DosSantos LC (2014). Characterization and quantification of the compounds of the ethanolic extract from Caesalpinia ferrea stem bark and evaluation of their mutagenic activity. Molecules 19:16039-16057.
Crossref

 
 

Yassien M, Khardori N. (2004). Biofilms formation by Staphylococcus epidermidis modulation by fluoroquinolones. Egy. J. Biomed. Sci. 16:1-20.

 
 

Zhang J, Li L, Kim S, Hagerman A, Lu J (2009). Anti-cancer, anti-diabetic and other pharmacologic and biological activities of penta-galloyl-glucose. Pharm. Res. 26:2066-2080.
Crossref