Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3704

Full Length Research Paper

Phytochemical screening and In Vivo antimalarial activities of crude extracts of Lantana trifolia root and Premna oligotricha leaves in plasmodium berghei infected mice

Sisay Seyfe
  • Sisay Seyfe
  • Biochemistry Unit, Faculty of Medical Sciences, Hawassa University, Ethiopia.
  • Google Scholar
Alemayehu Toma
  • Alemayehu Toma
  • Pharmacology Unit, Faculty of Medical Sciences, Hawassa University, Ethiopia.
  • Google Scholar
Atkilt Esaiyas
  • Atkilt Esaiyas
  • Physiology Unit, Faculty of Medical Sciences, Hawassa University, Ethiopia.
  • Google Scholar
Etana Debela
  • Etana Debela
  • Biomedical Module, Faculty of Veternery Medicine, Hawassa University, Ethiopia.
  • Google Scholar
Abraham Fikru
  • Abraham Fikru
  • Biomedical Team, Faculty of Veternery Sciences, Hawassa University, Ethiopia.
  • Google Scholar
Amelework Eyado
  • Amelework Eyado
  • Department of Biology, College of Natural and Computational Sciences, Addis Ababa University, Ethiopia.
  • Google Scholar


  •  Received: 13 October 2017
  •  Accepted: 09 November 2017
  •  Published: 17 December 2017

References

Adhanom TDW, Witten HK, Getachew A, Seboxa T (2006). Malaria in the epidemiology and ecology of health and disease in Ethiopia 1st edition. Ababa Addis, Ethiopia: Shama PLC. pp. 556-576.

 

Ayoola GA, Coker HB, Adesegun SA, Adepoju-Bello AA, Obaweya K, Ezennia EC, Atangbayila TO (2008). Phytochemical Screening and Antioxidant activities of Some Selected Medicinal Plants Used for Malaria Therapy in Southwestern Nigeria. Trop. J. Pharm. Res. 7(3):1019-1024.

 
 

Birru M, Geta M, Gurmu E (2017). Antiplasmodial activity of Indigofera spicata root extract against Plasmodium berghei infection in mice. Malar. J. 16:198.
Crossref

 
 

Builders M, Wannang N, Aguiyi J (2011). Antiplasmodial activities of parkia biglobosa: in vivo and in vitro studies. Ann Biol Res. 2:8-20.

 
 

Debella A (2002). Manual for phytochemical screening of medicinal plants. Ethiopian Health and Nutrition Research Institute, Addis Ababa, Ethiopia. pp. 35-47.

 
 

Dikasso D, Makonnen E, Debella A, Abebe D, Urga K, Menonnen W, Melaku D, Assefa A, Meknonnen Y (2006). In vivo antimalarial activity of hydroalcoholic extracts from Asparagus africanus Lam. in mice infected with Plasmodium berghei. Ethiop. J. Health Dev. 20:112-118.

 
 

European Community Guidelines (1986). Council directive of 24 November 1986 on the approximation of laws, regulations and administrative provisions of the Member States regarding the protection of animals used for experimental and other scientific purposes (86/609/EEC). Off. J. Eur. Commun. 358:1-29. Available at: 

View

 
 

Fentahun S, Makonnen E, Awas T, Giday M (2017). In vivo antimalarial activity of crude extracts and solvent fractions of leaves of Strychnos mitis in Plasmodium berghei infected mice. BMC Complement. Altern. Med. 17:13.
Crossref

 
 

Gebretsadik G, Mekonnen Y (2016). In vivo Antiplasmodial Activity of Fractions and Chromatographic Sub Fractionions of Ethanol Extract of Clerodendrum Myricoides Leaves. J. Drug Design Med. Chem. 2(6):60-64.
Crossref

 
 

Gebreyohannes AE, Bhagavathula AS, Seid SA, Tegegn GH (2017). Antimalarial treatment outcomes in Ethiopia: a systematic review and meta-analysis. Malar J. 16:269.
Crossref

 
 

Habtemariam S, Gray A, Waterman P (1991). Flavonoids from three Ethiopian species of Premna. Zeitschrift für Naturforschung 47b(1):144-147.

 
 

Johnson IS, Ettebong EO, Okokon JE (2017). In vivo antiplasmodial activities of ethanolic leaf extract and fractions of Hilleria latifolia. J. Med. Plants Stud. 5(4):118-122.

 
 

Jones P, Kinghorn D (2006). Extraction of plant secondary metabolites. In Methods in Biotechnology Natural Products Isolation. 2nd edition. Edited by Sarker D, Latif Z, Gray A. Nerw Jersey: Human Press. pp. 323-351.
Crossref

 
 

Ketemma T, Etana D, Athanasiadou S, Adugna T, Gebeyehu G, Hoduijk G (2013). Ethno-medicinal study of plants used for treatment of human and livestock aliments by traditional healers in South Omo, Southern Ethiopia. J. Ethnobiol. Ethnomed. 9(32):1-15.

 
 

Kilama WL (2005). Ethical perspective on malaria research for Africa. Acta Trop. 95:276-284.
Crossref

 
 

Knight DJ, Peters W (1980). The antimalarial activity of N-benzyloxydihydrotriazines: I. The activity of clociguanil (BRL 50216) against rodent malaria, and studies on its mode of action. Ann. Trop. Med. Parasitol. 74(4):393-404.
Crossref

 
 

Mengiste B, Makonnen E, Urga K (2012). In vivo antimalarial activity of Dodonaea Angustifolia seed extracts against Plasmodium berghei in mice model. Momona Ethiop. J. Sci. 4(1):47-63.

 
 

Mukungu N, Abuga K, Okalebo F, Ingwela R, Mwangi J (2016). Medicinal plants used for management of malaria among the Luhya community of Kakamega East sub-County, Kenya. J. Ethnopharmacol. 194:98-107.
Crossref

 
 

Nalubega R, Nyanzi SA, Nakavuma JL, Kamatenesi-Mugisha M (2013). Ethnobotanical uses of Lantana trifolia L. and Sida cuneifolia Roxb. in Mukungwe and Wabinyonyi Sub-counties of Central Uganda. J. Intercult. Ethnopharmacol. 2(3):155-164.
Crossref

 
 

Ocho D, Stuik P, Price L, Kelbessa E, Kolo K (2012). Assessing the levels of food shortage using the traffic light metaphor by analysing the gathering and crop residues in Konso, Ethiopia. J. Ethnobiol. Ethnomed. 8(1):30.
Crossref

 
 

Okafor A, Nok A, Inuwa H (2013). Antiplasmodial Activity of Aqueous leaf Extract of Mucuna Pruriens Linn in Mice Infected with Plasmodium Berghei (Nk-65 Strain). J. Appl. Pharm. Sci. 3(4 Suppl 1):S52-S55.

 
 

Okokon JE, Ita BN, Udokpoh AE (2006). The in-vivo antimalarial activities of Uvaria chamae and Hippocratea africana. Ann. Trop. Med. Parasitol. 100(7):585-590.
Crossref

 
 

Silva GN, Martins FR, Matheus ME, Leitao SG, Fernandes PD (2005). Investigation of Anti-inflammatory and antinoceptive activities of Lantana trifolia. J. Ethnopharmacol. 100:254-259.
Crossref

 
 

Tadesse SA, Wubneh ZB (2017). Antimalarial activity of Syzygium guineense during early and established Plasmodium infection in rodent models. BMC Complement. Altern. Med. 17:21.
Crossref

 
 

Tchoumbougnang F, Amvam Zollo P, Dagne E, Mekonnen Y (2004). In vivo antimalarial activity of essential oils from Cymbopogon citratus and Ocimum gratissimum on mice infected with Plasmodium berghei. Planta Med. 70:1-4.

 
 

Toma A, Deyno S, Fikru A, Eyado A, Beale A (2015). In vivo antiplasmodial and toxicological effect of crude ethanol extract of Echinops kebericho traditionally used in treatment of malaria in Ethiopia. Malar. J. 14:196.
Crossref

 
 

Verma RK,Verma SK (2006). Phytochemical and termiticidal studies of Lantana camara var aculeata leaves. Fitoterapia 77:466-468.
Crossref

 
 

Waako P, Gumede B, Smith P, Folb P (2005). The in vitro and in vivo antimalarial activity of Cardiospermum halicacabum and Momordica foetida. J. Ethnopharmacol. 99:137-143.
Crossref

 
 

Waako P, Katuura E, Smith P, Folb P (2007). East African medicinal plants as a source of lead compounds for development of new antimalarial drugs. Afr. J. Ecol. 45:1-5.
Crossref

 
 

World Health Organisation (WHO) (2001). OECD guideline for testing of chemicals - Acute Oral Toxicity – Acute Toxic Class. Geneva: World Health Organization. Available at: 

View.

 
 

World Health Organisation (WHO) (2004). Communicable disease surveillance and response.

 
 

World Health Organisation (WHO) (2005). The leishmaniasis and leishmania/HIV co-infection: Fact Sheets.

 
 

World Health Organisation (WHO) (2015). World Health Organization Malaria Report: Prospects for malaria elimination. Tecn. Rep. Serv. 1667:1-8.

 
 

Yang ZG, Sun HX, Fang WH (2005). Hemolytic activities and adjuvant effect of Astragalus membranaceus saponins on the immune responses to ovalbumin in mice. Vaccine 23(44):5196-5203.
Crossref