The present work aimed to investigate physiopathological changes associated with the ethanolic extract of the stem leaves of Phyllanthus amarus (EEt(OH) P.a. Exploratory tests are performed in vivo on Wistar albino rats. Analysis of the variation in body weight at the level of the batch having received, and the control group showed a slight weight drop 7 d after treatment. This variation is not significant (p>0.05). The means relative organ weights show that there were no significant changes between control and treated groups (P Ëƒ 0.05). No obvious clinical signs (tremor, breathing rate, paralysis). Slightly greater differences were noted for WBC of the Control group and rats treaded with EEt(OH) P.a (5000 mg/kg b.w.) on day 14 after the administration. These differences were statistically significant (p<0.05). Similarly, the platelet count was slightly lower for the control rats compared to the rats treaded. The various biochemical parameters explored, Glucose, Bilirubin (BIL), Alanine amino transferase (ALT), Aspartate amino transferase (AST), Total protein (TP), alkaline phosphatase (ALP), urea (URE), creatinine (CR), Total bilirubin (TBIL) and Indirect bilirubin (IBIL), have informed us about the probable effects of the stem leaves of Phyllanthus amarus in the liver and kidney. There was no significant differences (p>0.05) in glucose, total protein, urea, creatinine levels between control and experiemental groups at 14 d. Total bilirubin (TBIL) and Indirect bilirubin (IBIL), however, were statistically significant (p<0.05). Other biochemical parameters such as ALT, AST, ALP show statistically insignificant difference (p>0.05) in test and control batch.
Key words: Phyllanthus amarus Schum. & Thonn., physiopathological, breathing rate, paralysis, bilirubin, alanine amino, transferase, creatinine, alkaline, phosphatase, transaminases, aspartate amino.
EEt(OH)P.a, Ethanolic extract of the stem leaves of Phyllanthus amarus Schumach. & Thonn.; WBC, white blood cells; AST, aspartate amino transferase; ALT, Alanine amino transferase; ALP, alkaline phosphatase; BIL, bilirubin; TBIL, total bilirubin; IBIL, indirect bilirubin; TP, total protein; CR, creatinine; URE, urea.
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