Journal of
Physiology and Pathophysiology

  • Abbreviation: J. Physiol. Pathophysiol.
  • Language: English
  • ISSN: 2141-260X
  • DOI: 10.5897/JPAP
  • Start Year: 2010
  • Published Articles: 49

Full Length Research Paper

Adropin and irisin levels in a rat model of hypothyroidism

Mohamad Yosof Rezk
  • Mohamad Yosof Rezk
  • Medical Physiology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
  • Google Scholar
Rania Reafaat Abdel Kader Atia
  • Rania Reafaat Abdel Kader Atia
  • Medical Physiology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
  • Google Scholar


  •  Received: 10 June 2020
  •  Accepted: 09 September 2020
  •  Published: 31 October 2020

References

Aiceles V, Ramos CD (2016). A link between hypothyroidism, obesity and male reproduction. Hormone Molecular Biology and Clinical Investigation 25(1):5-13. 
Crossref

 

Akcilar R, Kocak FE, Simsek H, Akcilar A, Bayat Z, Ece E, Kokdasgil H (2016) Antidiabetic and hypolipidemic effects of adropin in streoptozotocin-induced type 2 diabetic rats. Bratislavské lekárske listy 117:100-105.
Crossref

 

Aydin S (2014). Three new players in energy regulation: Preptin, adropin and irisin. Peptides 56:94-110. 

View

 

Baron DN (1956). Hypothyroidism; its aetiology and relation to hypometabolism, hypercholesterolaemia, and increase in body-weight. Lancet 271: 277-281.
Crossref

 

Beigi A, Shirzad N, Nikpour F, Nasli Esfahani E, Emamgholipour S, Bandarian F (2015). Association between serum adropin levels and gestational diabetes mellitus; a case-control study. Gynecological Endocrinology 31:939-941.
Crossref

 

Biondi B (2010). Thyroid and obesity: an intriguing relationship. Journal of Clinical Endocrinology and Metabolism 95:3614-3617.
Crossref

 

Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, , Rasbach KA, Boström EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S, Højlund K, Gygi SP, Spiegelman BM (2012). A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 481(7382):463-8. 
Crossref

 

Butler AA, Zhang J, Price CA, Stevens JR, Graham JL, Stanhope KL, King S, Krauss RM, Bremer AA, Havel PJ (2019). Low plasma adropin concentrations increase risks of weight gain and metabolic dysregulation in response to a high-sugar diet in male nonhuman primates. The Journal of Biological Chemistry 294(25):9706-9719. 
Crossref

 

Choi YK, Kim MK, Bae KH, Seo HA, Jeong JY, Lee WK, Kim JG, Lee IK, Park KG (2013). Serum irisin levels in new-onset type 2 diabetes. Diabetes Research and Clinical Practice 100(1):96-101. 
Crossref

 

Cortés C, Eugenin E, Aliaga E, Carreño LJ, Bueno SM, Gonzalez PA, Gayol S, Naranjo D, Noches V, Marassi MP, Rosenthal D, Jadue C, Ibarra P, Keitel C, Wohllk N, Court F, Kalergis AM, Riedel CA (2012). Hypothyroidism in the adult rat causes incremental changes in brain derived neurotrophic factor, neuronal and astrocyte apoptosis, gliosis, and deterioration of postsynaptic density. Thyroid 22(9):951-63.
Crossref

 

Duntas LH & Biondi B (2013).The interconnections between obesity, thyroid function, and autoimmunity: the multifold role of leptin. Thyroid 23:646-653.
Crossref

 

Fossati P, Prencipe L (1982). Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide. Clinical Chemistry 28(10):2077-2080.
Crossref

 

Friedewald WT, Levy RI, Fredrickson DS (1972). Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical Chemistry 18(6):499-502.
Crossref

 

Ganesh KK, Zhang J, Gao S, Rossi J, McGuinness OP, Halem HH, Culler MD, Mynatt RL, Butler AA (2012). Adropin deficiency is associated with increased adiposity and insulin resistance. Obesity (Silver Spring) 20:1394-1402.
Crossref

 

Hersoug LG, Linneberg A (2007). The link between the epidemics of obesity and allergic diseases: does obesity induce decreased immune tolerance? Allergy 62:1205-1213.
Crossref

 

Huh JY, Panagiotou G, Mougios V, Brinkoetter M, Vamvini MT, Schneider BE, Mantzoros CS (2012). FNDC5 and irisin in humans: I. predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism 61(12):1725-1738.
Crossref

 

Humerah S, Siddiqui A, Khan HF (2016). Pattern of Altered Lipid Profile in Patients with Subclinical and Clinical Hypothyroidism and its Correlation with Body Mass Index. J Coll Physicians Surg Pak, 26(6): 463-6.

 

Iacobellis G, Ribaudo MC, Zappaterreno A, Iannucci CV, Leonetti F (2005). Relationship of thyroid function with body mass index, leptin, insulin sensitivity and adiponectin in euthyroid obese women. Clinical endocrinology 62(4):487-491.
Crossref

 

Johnson W (1919). Symptoms of hyperthyroidism observed in exhausted soldiers. BMJ 1:335-337.
Crossref

 

Kim Hj, So B, Choi M, Kang D, Song W (2015). Resistance exercise training increases the expression of irisin concomitant with improvement of muscle function in aging mice and humans. Experimental Gerontology 70:11-17.
Crossref

 

Klangjareonchai T, Nimitphong H, Saetung S, Bhirommuang N, Samittarucksa R, Chanprasertyothin S, Sudatip R, Ongphiphadhanaku B (2014). Circulating sclerostin and irisin are related and interact with gender to influence adiposity in adults with prediabetes. International Journal of Endocrinology 2014:261545.
Crossref

 

Kumar KG, Trevaskis JL, Lam DD, Sutton GM, Koza RA, Chouljenko VN, Kousoulas KJ, Rogers PM, Kesterson RA, Thearle M, Ferrante Jr AW, Mynatt RL, Burris TP, Dong JZ, Halem HA, Culler MD, Heisler LK, Stephens JM, Butler AA (2008). Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism. Cell Metabolism 8:468-481.
Crossref

 

Kume T, Calan M, Yilmaz O, Kocabas GU, Yesil P, Yesil P, Temur M, Bicer M, Calan OG (2016). A possible connection between tumor necrosis factor alpha and adropin levels in polycystic ovary syndrome. Journal of Endocrinological Investigation 39:747-754.
Crossref

 

Kyle LH, Ball MF, Doolan PD (1966). Effect of thyroid hormone on body composition in myxedema and obesity. New England Journal of Medicine 275:12-17.
Crossref

 

Laurberg P, Knudsen N, Andersen S, Carle' A, Pedersen IB, Karmisholt J (2012) Thyroid function and obesity. European Thyroid Journal 1:159-167.
Crossref

 

Legrand J (1967). Analysis of the morphogenetic action of thyroid hormones on the cerebellum of young rats. Archives d'anatomie microscopique et de morphologie expérimentale 56:205-244.

 

Liu R, Shi L, Peng N, Zhang Q, Li H (2019). Higher Baseline Serum Irisin Decreases Risk for Body Mass Index Increment in Chinese Populations: A 3.2-Year Cohort Study. Diabetes Therapy 10(2):713-723.
Crossref

 

Liu Z, Chen Y, Chen G, Mao X, Wei X, Li X, Xu Y, Jiang F, Wang K, Liu C (2019). Impaired Glucose Metabolism in Young Offspring of Female Rats with Hypothyroidism. Journal of Diabetes Research 21:4713906.
Crossref

 

Lopez-Legarrea P, de la Lglesia R, Crujeiras AB, Pardo M, Casanueva FF, Zulet MA, Martinez JA (2014). Higher baseline irisin concentrations are associated with greater reduction in glycemia and insulinemia after weight loss in obese subjects. Nutrition and Diabetes 4:e110.
Crossref

 

Majeed S, Shafi R, Moin H, Ashraf I, Irshad K, Liaquat A (2019). Effects of Recombinant Irisin on Body Mass Index, Serum Insulin, Luteinizing Hormone and Testosterone Levels in Obese Female BALB/c Mice. Journal of the College of Physicians and Surgeons Pakistan 29(8):736-740. 
Crossref

 

Martinez Munoz IY, Camarillo Romero EDS, Garduno Garcia JJ (2018). Irisin a Novel Metabolic Biomarker: Present Knowledge and Future Directions. International Journal of Endocrinology 9:2018:7816806.
Crossref

 

Moreno M, Moreno-Navarrete JM, Serrano M, Ortega F, Delgado E, Sanchez-Ragnarsson C, Valdés S, Botas P, Ricart W, Fernández-Real JM (2015). Circulating irisin levels are positively associated with metabolic risk factors in sedentary subjects. PLoS One. 10(4):e0124100. 
Crossref

 

Nauck MA, Holst JJ, Willms B (1997). Glucagon-like peptide 1 and its potential in the treatment of non-insulin-dependent diabetes mellitus. Hormone and Metabolic Research 29(9):411-416 [PMID: 9370106.

 

Niranjan SB, Belwalkar SV, Tambe S, Venkataraman K, Mookhtiar KA (2019). Recombinant irisin induces weight loss in high fat DIO mice through increase in energy consumption and thermogenesis. Biochemical and Biophysical Research Communications 519(2):422-429.
Crossref

 

Panati K, Suneetha Y, Narala VR (2016). Irisin/FNDC5--An updated review. European Review for Medical and Pharmacological Sciences 20(4):689-97.

 

Pearce E (2012). Thyroid hormone and obesity. Current Opinion in Endocrinology, Diabetes, and Obesity 19:408-413.
Crossref

 

Procaccini C, Carbone F, Galgani M, La Rocca C, De RosaV, Cassano S, Matarese G (2011). Obesity and susceptibility to autoimmune diseases. Expert Review of Clinical Immunology, 7:287-294.
Crossref

 

Reinehr T (2011). Thyroid function in the nutritionally obese child and adolescent. Current Opinion in Pediatrics 23:415-420.
Crossref

 

Rotondi M, Magri F, Chiovato L (2011). Thyroid and obesity: not a one-way interaction. Journal of Clinical Endocrinology and Metabolism 96:344-346.
Crossref

 

Santini F, Pinchera A, Marsili A, Ceccarini G, Castagna MG, Valeriano R, Giannetti M, Taddei D, Centoni R, Scartabelli G, Rago T, Mammoli C, Elisei R, Vitti P (2005). Lean body mass is a major determinant of levothyroxine dosage in the treatment of thyroid diseases. Journal of Clinical Endocrinology and Metabolism, 90:124-127.
Crossref

 

Santini F, Marzullo P, Rotondi M, Ceccarini G, Pagano L, Ippolito S, Chiovato L, Biondi B (2014). Mechanisms in endocrinology: the crosstalk between thyroid gland and adipose tissue: signal integration in health and disease. European Journal of Endocrinology 171(4):R137-52.
Crossref

 

Sayın O, Tokgöz Y, Arslan N (2014). Investigation of adropin and leptin levels in pediatric obesity-related non‐ alcoholic fatty liver disease. Journal of Pediatric Endocrinology and Metabolism 27(5-6):479-484.
Crossref

 

Seppel T, Kosel A, Schlaghecke R (1997). Bioelectrical impedance assessment of body composition in thyroid disease. European Journal of Endocrinology 136:493-498.
Crossref

 

Smith TJ, Bahn RS, Gorman CA (1989). Connective tissue, glycosaminoglycans, and diseases of the thyroid. Endocrine Reviews 10:366-391.
Crossref

 

Tietz, NW (1995). Clinical Guide to Laboratory Tests, 3rd Ed., pbl: W.B. Saunders Company, Philadelphia pp. 509-580.

 

Tomer Y, Davies TF (2003). Searching for the autoimmune thyroid disease susceptibility genes: from gene mapping to gene function. Endocrine Reviews 24:694-717.
Crossref

 

Wang SH, Chen GH, Fan Y, Van Antwerp M, Baker JR (2009). Tumor necrosis factor-related apoptosis-inducing ligand inhibits experimental autoimmune thyroiditis by the expansion of CD4CCD25Cregulatory T cells. Endocrinology 150: 2000-2007.
Crossref

 

Wolf M, Weigert A, Kreymann G (1996). Body composition and energy expenditure in thyroidectomized patients during short-term hypothyroidism and thyrotropin-suppressive thyroxine therapy. European Journal of Endocrinology 134:168-173.
Crossref

 

Wu L, Fang J, Chen L, Zhao Z, Luo Y, Lin C, Fan L (2014). Low serum adropin is associated with coronary atherosclerosis in type 2 diabetic and non-diabetic patients. Clinical Chemistry and Laboratory Medicine 52:751-758. 
Crossref

 

Yosaee S, Khodadost M, Esteghamati A, Speakman JR, Shidfar F, Nazari MN, Bitarafan V, Djafarian K (2017). Metabolic syndrome patients have lower levels of adropin when compared with healthy over‐ weight/obese and lean subjects. American Journal of Men's Health 11:426-434.
Crossref

 

Zang H, Jiang F, Cheng X, Xu H, Hu X (2018). Serum adropin levels are decreased in Chinese type 2 diabetic patients and negatively correlated with body mass index. Endocrine Journal 65(7):685-691. 
Crossref

 

Zhang Y, Li R, Meng Y, Li S, Donelan W, Zhao Y, Qi L, Zhang M, Wang X, Cui T, Yang, L, Tang D (2014). Irisin stimulates browning of white adipocytes through mitogen-activated protein kinase p38 MAP kinase and ERK MAP kinase signaling. Diabetes 63(2):514-525. 
Crossref

 

Zhou X, Li R, Liu X, Wang L, Hui P, Chan L, Saha PK, Hu Z (2016). ROCK1 reduces mitochondrial content and irisin production in muscle suppressing adipocyte browning and impairing insulin sensitivity. Scientific Reports 2016;6:29669.
Crossref