Journal of
Physiology and Pathophysiology

  • Abbreviation: J. Physiol. Pathophysiol.
  • Language: English
  • ISSN: 2141-260X
  • DOI: 10.5897/JPAP
  • Start Year: 2010
  • Published Articles: 49

Full Length Research Paper

Protective effect of ghrelin on paracetamol induced acute hepatotoxicity in rats

Ahmed K. Alantary
  • Ahmed K. Alantary
  • Physiology Department, Faculty of Medicine, Thamar University,Yemen.
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Mohamad Y. Rezk*
  • Mohamad Y. Rezk*
  • Physiology department, Faculty of Medicine, Zagazig University, Egypt.
  • Google Scholar
Khaled E.A. Soliman
  • Khaled E.A. Soliman
  • Forensic medicine and clinical Toxicology Department, Faculty of Medicine, Sohag University, Egypt.
  • Google Scholar


  •  Received: 03 May 2014
  •  Accepted: 22 August 2014
  •  Published: 28 August 2014

References

Abraham P (2005). Oxidative stress in paracetamol-induced pathogenesis: (I) Renal damage. Indian J. Biochem. Biophys. 42:59–62.
PubMed
 
Ahmed M, Khater MR (2001). Evaluation of the protective effect of Ambrosia maritime extract on acetaminophen-induced liver damage. J. Ethnopharmacol. 75:169–74.
Crossref
 
Alam J, Stewart D, Touchard C, Boinapally S, Choi AM, Cook JL (1999). Nrf2, a Cap 'n' Collar transcription factor, regulates induction of the heme oxygenase-1 gene. J. Biol. Chem. 274:26071–8.
Crossref
 
Archer S (1993). Measurement of nitric oxide in biological models. FASEB J. 7(2):349-60.
PubMed
 
Arıcı ÖF, Çetin N (2010). Protective role of ghrelin against carbon tetrachloride (CCl4)-induced coagulation disturbances in rats. Regul. Pept. 166:139–42.
Crossref
 
Bauer M, Bauer I (2002). Heme Oxygenase-1: redox regulation and role in the hepatic response to oxidative stress. Antioxid. Redox Signal 4:749–58.
Crossref
 
Brzozowski T, Konturek PC, Konturek SJ,KwiecieÅ„ S, Drozdowicz D, Bielanski W, Pajdo R, Ptak A, Nikiforuk A, Pawlik WW, Hahn EG (2004). Exogenous and endogenous ghrelin ingastroprotection against stress-induced gastric damage. Regul. Pept. 120:39–51.
Crossref
 
Chamulitrat W, Jordan SJ, Mason RP (1994). Nitric oxide production during endotoxic shock in carbon tetrachloride-treated rats. Mol. Pharmacol. 46:391–7.
PubMed
 
Chan K, Han XD, Kan YW (2001). An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen. Proc. Natl. Acad. Sci. 98:4611–6.
Crossref
 
Chandan BK, Saxena AK, Shukla S, Sharma N, Gupta DK, Suri KA, Suri J, Bhadauria M, Singh B (2007). Hepatoprotective potential of Aloe barbadensis Mill. against carbon tetrachloride induced hepatotoxicity. J. Ethno¬pharmacol. 111:560–6.
 
Chang L, Ren Y, Liu X, Li WG, Yang J, Geng B, Weintraub NL, Tang C(2004). Protective effects of ghrelin on ischemia/ reperfusion injury in the isolated rat heart. J. Cardiovasc. Pharmacol. 43:165–70.
Crossref
 
Chen AS, Taguchi T, Sakai K, Matahira Y, Wang MW, Miwa I (2005). Effect of chitobiose and chitotriose on carbon tetrachloride-induced acute hepatotoxicity in rats. Biol. Pharm. Bull. 10:1971–3.
Crossref
 
Cottart CH, Do L, Blanc MC, Vaubourdolle M, Descamps G, Durand D,Galen FX, Clot JP (1999). Hepatoprotective effect of endogenous nitric oxide during ischemia-reperfusion in the rat. Hepatology 29:809–13.
Crossref
 
Eter E, Tuwaijiri A, Hagar H, Arafa M (2007). In vivo and in vitro antioxidant activity of ghrelin: attenuation of gastric ischemic injury in the rat. J. Gastroenterol. Hepatol. 22:1791–9.
Crossref
 
Gnanapavan S, Kola B, Bustin SA, Morris DG, McGee P, Fairclough P, Bhattacharya S, Carpenter R, Grossman AB, Korbonits M (2002). The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans. J. Clin. Endocrinol. Metab. 87:2988–91.
Crossref
 
Gupta Ajay K, Chitme H, Dass SK, Misra N (2006). Hepatoprotective activity of Rauwolfiaserpentina rhizome in paracetamol intoxicated rats. J. Pharmacol Toxicol. Methods 1:82–88.
Crossref
 
IÅŸeri SO, Sener G, Saglam B, Ercan F, Gedik N, Yegen BÇ (2008). Ghrelin alleviates biliary obstruction induced chronic hepatic injury in rats. Regul. Pept.146:73–9.
Crossref
 
IÅŸeri SO, Sener G, Yüksel M, Contuk G, Cetinel S, Gedik N, Yegen BC (2005). Ghrelin against alendronate-induced gastric damage in rats. J. Endocrinol. 187:399–406.
Crossref
 
Jahromi MG, Nabavizadeh F, Vahedian J, Nahrevanian H, Dehpour AR, Zare-Mehrjardi A (2010). Protective effect of ghrelin on acetaminophen-induced liver injury in rat. Peptides 11:2114–7.
Crossref
 
Kawachi S, Hines IN, Laroux FS, Hoffman J, Bharwani S, Gray L,Leffer D, Grisham MB (2000). Nitric oxide synthase and postischemic liver injury. Biochem. Biophys. Res. Commun. 276:851–4.
Crossref
 
Kheradmand A, Alirezael M, Asadian P, Alavi ER, Joorabi S (2009). Antioxidant enzyme activity and MDA level in the rat testis following chronic administration of ghrelin. Andrologia 41:335–40.
Crossref
 
Kheradmand A, Alirezael M, Birjandi M (2010). Ghrelin promotes antioxidant enzyme activity and reduces lipid peroxidation in the rat ovary. Regul. Pept. 162:84–9.
Crossref
 
Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K (1999). Ghrelin is a growthhormone releasing acylated peptide from stomach. Nature 402:656–60.
Crossref
 
Lee CP, Shih PH, Hsu CL, Yen GC (2007). Hepatoprotection of tea seed oil (Camellia oleifera Abel.) against CCl4-induced oxidative damage in rats. Food Chem. Toxicol. 45: 888–95.
Crossref
 
Li J, Stein TD, Johnson J.A. (2004). Genetic dissection of systemic autoimmune disease in Nrf2-deficient mice. Physiol. Genomics 18:261–72.
Crossref
 
Liu P, Xu B, Spokas E, Lai PS, Wong PY (2000). Role of endogenous nitric oxide in TNF-alpha and IL-1beta generation in hepatic ischemia-reperfusion. Shock13: 217–23.
Crossref
 
Luck H. (1965). Catalase. In: Bergmeyer H (ed.), Methods of enzymatic analysis. Academic Press, New York; p. 855–84.
Crossref
 
Madkour FF, Abdel-Daim MM (2013). Hepatoprotective and Antioxidant Activity of Dunaliella salina in paracetamol-induced Acute Toxicity in Rats. Indian J. Pharm. Sci. 75(6):642-8.
PubMed
 
Moreno M, Chaves JF, Sancho-Bru P, Ramalho F, Ramalho LN, Mansego ML,Ivorra C, Dominguez M, Conde L, Millán C, Marí M, Colmenero J, Lozano JJ, Jares P, Vidal J, Forns X, Arroyo V, Caballería J, Ginès P, Bataller R (2010). Ghrelin attenuates hepato-cellular injury and liver fibrogenesis in rodents and influences fibrosis progression in humans. Hepatology 51:974–85.
Crossref
 
Mujeeb M, Aeri V, Bagri P, Khan S (2009). Hepatoprotective activity of the methanolic extract of Tylophoraindica (Burm. f.) Merill. leaves. Int. J. Green Pharm. 3(2):125–127.
Crossref
 
Nakahira K, Takahashi T, Shimizu H, Maeshima K, Uehara K, Fujii H, Nakatsuka H, Yokoyama M, Akagi R, Morita K (2003). Protective role of heme oxygenase-1 induction in carbon tetrachloride-induced hepatotoxicity. Biochem Pharmacol. 66:1091–105.
Crossref
 
Obay BD Tasdemir E, Tumer C, Bilgin HM, Atmaca M (2008). Dose dependent effects of ghrelin on pentylenetetrazole induced oxidative stress in a rat seizure model. Peptides.29:448–55.
Crossref
 
Ohkawa H, Ohishi N, Yagi K (1978). Reaction of linoleic acid hydroperoxide with thiobarbutiric acid. J. Lipid Res. 19:1053–7.
PubMed
 
Ohta Y, Nishida K, Sasaki E, Kongo M, Ishiguro I (1997). Attenuation of disrupted hepatic active oxygen metabolism with the recovery of acute liver injury in rats intoxicated with carbon tetrachloride. Res. Commun. Mol. Pathol. Pharmacol. 95:191 –207.
PubMed
 
Paglia PE, Valentine WN (1967). Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J. Lab. Clin. Med. 70:158–69.
PubMed
 
Radi R, Beckman JS, Bush KM, Freeman BA (1991). Peroxynitrite oxidation of sulfhydryls: the cytotoxic potential of superoxide and nitric oxide. J. Biol. Chem. 266: 4244–50.
PubMed
 
Rajkapoor B, Venugopal Y, Anbu J, Harikrishnan N, Gobinath M, Ravichandran V (2008). Protective effect of Phyllanthus polyphyllus on acetaminophen induced hepatotoxicity in rats. Pak. J. Pharm Sci. 21(1):57–62.
 
Rodenas J, Carbonell T, Mitjavila MT (2000). Different roles for nitrogen monoxide and peroxynitrite in lipid peroxidation induced by activated neutrophil. Free Radic. Biol. Med. 28:374–80.
Crossref
 
Sibilia V, Rindi G, Pagani F, Rapetti D, Locatelli V, Torsello A,Campanini N, Deghenghi R, Netti C (2003). Ghrelin protects against ethanol-induced gastric ulcers in rats: studies on the mechanisms of action. Endocrinology 144:353–9.
Crossref
 
Srinivasan C, Williams WM, Ray MB, Chen TS (2001). Prevention of acetaminophen-induced liver toxicity by 2(R, S)-n-propylthiazolidine-4(R)-carboxylic acid in mice. Biochem. Pharmacol. 61: 245–52.
Crossref
 
Sun Y, Oberley LW, Li Y (1988). A simple method for clinical assay of superoxide dismutase. Clin Chem. 34:497–500.
PubMed
 
Taniguchi M, Takeuchi T, Nakatsuka R, Watanabe T, Sato K (2004). Molecular process in acute liver injury and regeneration induced by carbon tetrachloride. Life Sci. 75:1539–49.
Crossref
 
Weber LWD, Boll M, Stampfl A (2003). Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model. Crit. Rev. Toxicol. 33:105–36.
Crossref
 
Winterbourn CC, Hawkins RE, Brian M, Carrell RW (1975). The estimation of red cell superoxide activity. J. Lab. Clin Med. 85:337–41.
PubMed
 
Xu Z, Lin S, Wu W, Tan H, Wang Z, Cheng C, Lu L, Zhang X (2008). Ghrelin prevents doxorubicin induced cardiotoxicity through TNF-alpha/NF-κB pathways and mitochondrial protective mechanisms. Toxicology 247:133–8.
Crossref
 
Yada T, Kaiya H, Mutoh K, Azuma T, Hyodo S, Kangava K (2006). Ghrelin stimulates phagocytosis and superoxide production in fish leukocytes. J. Endocrinol. 189:57–65.
Crossref
 
Yanpallewar SU Sen S, Tapas S, Kumar M, Raju SS, Acharya SB (2003). Effect of Azadirachtaindica on paracetamol-induced hepatic damage in Albino rats. Phytomedicine 10(5):391–396.
Crossref
 
Yoshioka T, Kawada K, Shimada T, Mori M (1979). Lipid peroxidation in maternal and cordblood and protective mechanism against active-oxygen toxicity in the blood. Am. J. Obstet. Gynecol. 135:372–6.
PubMed
 
Zhu W, Fung PC (2000). The roles played by crucial free radicals like lipid free radicals, nitric oxide, and enzymes NOS and NADPH in CCl4-induced acute liver injury of mice. Free Radic. Biol. Med. 29:870–80.
Crossref
 
Zwirska-Korczala K, Adamczyk-Sowa M, Sowa P,Pilc K, Suchanek R, Pierzchala K,Namyslowski G, Misiolek M, Sodowski K, Kato I, Kuwahara A, Zabielski R (2007). Role of leptin, ghrelin, angiotensin II and orexins in 3 T3 L1 preadipocyte cells proliferation and oxidative metabolism. J. Physiol. Pharmacol. 58:53–64.