Journal of
Public Health and Epidemiology

  • Abbreviation: J. Public Health Epidemiol.
  • Language: English
  • ISSN: 2141-2316
  • DOI: 10.5897/JPHE
  • Start Year: 2009
  • Published Articles: 569

Full Length Research Paper

Association between O blood group and Helicobacter pylori infection: A systematic review and meta-analysis

Debebe Shaweno1* and Deresse Daka2
1Lecturer of Epidemiology, School of Public and Environmental Health, College of Medicine and Health sciences, Hawassa University, Ethiopia. 2Lecturer of Medical Microbiology, Department of Medical Laboratory Science, College of Medicine and Health sciences, Hawassa University, Ethiopia.
Email: [email protected]

  •  Accepted: 07 November 2013
  •  Published: 31 December 2013

Abstract

Helicobacter pylori (H. pylori) infection is associated with several diseases including gastritis, gastric ulcer, pancreatic cancer and iron deficiency anemia. Different epidemiological studies reported controversial findings on the association between O blood group and H. pylori infection. This meta-analysis was conducted to verify the association between H. pylori infection and O blood group. Random-effects model was used to pool data on the association between H. pylori infection and O blood group in 18 selected studies. DerSimonian Liard statistic was used to estimate the effect size. Stability of the pooled estimates was assessed by sensitivity analysis. Publication bias was assessed by using funnel plot and Egger’s test. Fourteen of the 18 included studies reported no significant association between H. pylori infection and O blood group. Among ten reviewed studies which were conducted among dyspeptic patients, four showed statistically significant association. However, none of six studies conducted among asymptomatic patients demonstrated statistically significant association. The pooled effect size showed no statistically significant association between O blood group and H. pylori infection (odds ratio (OR) = 1.18, 95% CI [0.95, 1.48]). However, the pooled effect size under stratified meta-analysis turned to be statistical significant among studies conducted in dyspeptic patients (OR = 1.44; 95% CI [1.03, 2.01]). The analysis did not show statistically significant association between H. pylori infection and O blood group among all study participants. However, statistically significant association between H. pylori infection and O blood group was observed in a subset of studies conducted among dyspeptic patients. Caution should be made while interpreting the finding as the severity of dyspepsia is not standardized and different H. pylori strains were not taken into account.

Key words: Helicobacter pylori, ABO blood group, O blood group, meta-analysis.