Journal of
Public Health and Epidemiology

  • Abbreviation: J. Public Health Epidemiol.
  • Language: English
  • ISSN: 2141-2316
  • DOI: 10.5897/JPHE
  • Start Year: 2009
  • Published Articles: 584

Full Length Research Paper

Factors associated with pulmonary tuberculosis treatment failure in Togo, 2015-2016

Tchalla Abalo Agballa Mébiny-Essoh1, Yanogo Pauline Kiswendsida1,2*, Adjoh Komi Séraphin3,4, Diallo Fadima1, Assane Hamadi1, Naba Mouchédou Abdelkarim1, Halatoko Wemboo Afiwa1, Sawadogo Bernard1, Antara Simon1, McKenzie Andre1, Sawadogo Mamadou1,2 and Meda Nicolas1,2
1West Africa Field Epidemiology Training Program, University Joseph KI-ZERBO, Burkina Faso. 2Faculty of Medicine, University Joseph Ki – Zerbo, Burkina Faso. 3Faculty of Health Sciences, University of Lomé, Togo. 4Sylvanus Olympio University Hospital, Lomé, Togo.
Email: [email protected]

  •  Received: 08 August 2019
  •  Accepted: 24 October 2019
  •  Published: 30 November 2019


Tuberculosis (TB) treatment failure compromises its elimination as recommended by Sustainable Development Goals. The purpose of this study is to determine the factors associated with pulmonary TB treatment failure in Togo between 2015 and 2016. An unmatched case-control study was conducted on cases of pulmonary TB under treatment at all of 47 TB Diagnostic and Treatment Centers (DTC) in Togo between 2015 and 2016. Treatment failure of TB was defined as any patient whose sputum smear or culture was positive at the fifth month or later during treatment. Controls were patients whose smear sputum was negative at the fifth month of treatment or later. Logistic regression model was performed to identify independently associated factors by calculating Adjusted Odds Ratio (AOR). In multivariate analysis, factors associated with treatment failure were: Positive sputum result in second month (AOR = 38.75; 95% CI [10.52-142.76], p≤0.001), occurrence of side effects [AOR=3, 61; 95% CI (1.06-12.22), p=0.038], treatment interruption for at least 14 days [AOR=8.15; 95% CI (2.35-28.28), p≤0.001], absence of family-based Directly Observed Treatment practice (AOR=23.76; 95% CI [5.66-99.64], p≤0.001). The study identified the socio-demographic and clinical factors of TB treatment failure whose inclusion in action plans would contribute to achieve TB elimination in Togo.

Key words: Tuberculosis, treatment failure, directly observed treatment short-course, Togo.