The ethanolic extract of the leaves of Rivea hypocrateriformis obtained by soxhlet extraction method was evaluated for analgesic action by Radiant Heat Tail Flick method and was tested for anti-inflammatory action by carrageenan induced paw edema. The ethanolic extract in doses of 200 and 400 mg/kg of Body weight showed 64.83 and 100% inhibition of paw edema, respectively at the end of three hours compared to that of standard Ibuprofen (87.04%). In the Radiant Heat Tail Flick model, the ethanolic extract at high dose 400 mg/kg of Body weight increased the pain threshold significantly after 30 min, 1, 2 and 4 h of administration. The ethanolic extract showed dose-dependent action in all the experimental models. The results were analyzed for statistical significance using two-way ANOVA followed by Dunnel’s test. A P value < 0.05 is considered significant.
Key words: Carrageenan induced paw edema, ethanolic extract Rivea hypocrateriformis, Tail flick method.
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