Journal of
Pharmacognosy and Phytotherapy

  • Abbreviation: J. Pharmacognosy Phytother.
  • Language: English
  • ISSN: 2141-2502
  • DOI: 10.5897/JPP
  • Start Year: 2009
  • Published Articles: 223

Full Length Research Paper

Quality control standardization and evaluation of the anti-inflammatory and antipyretic effects of the leaves and stem bark of Amphimas pterocarpoides harms (Leguminosae)

George Adjei-Hinneh
  • George Adjei-Hinneh
  • Department of Pharmaceutical Sciences, Sunyani Technical University, Sunyani, Ghana.
  • Google Scholar
Gustav Komlaga
  • Gustav Komlaga
  • Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health
  • Google Scholar
Evelyn Asante-Kwatia
  • Evelyn Asante-Kwatia
  • Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health
  • Google Scholar
Abraham Yeboah Mensah
  • Abraham Yeboah Mensah
  • Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health
  • Google Scholar


  •  Received: 21 December 2020
  •  Accepted: 11 March 2021
  •  Published: 30 April 2021

Abstract

Amphimas pterocarpoides is used traditionally for the treatment of oedema, infections, malaria and skin diseases. This study described pharmacognostic and physicochemical parameters of the leaf and stem bark. The carrageenan-induced foot oedema and the baker’s yeast-induced pyrexia were used to assess the anti-inflammatory and antipyretic activities respectively. The leaf of A. pterocarpoides is oddly pinnate compound, oblong in shape with acuminate apex and obtuse base. The stem bark is scaly and rugged and exudes a reddish resin when bruised. Leaf microscopy displayed wavy-walled epidermal cells, paracytic stomata, glandular and clothing trichomes, bean-shaped lignified vascular bundle, prismatic calcium oxalate crystals. The leaf (APL) and stem bark (APSB) extracts (30-300 mg/kg p.o.) significantly inhibited foot oedema in chicks with maximum percentage inhibition of 76.65 ± 6.27% and 77.04 ± 2.53% respectively [ED50 = 225.3± 31.52 mg/kg (APL) and 178.9 ± 29.57 mg/kg (APSB)]. APL, APSB and paracetamol also showed significant antipyretic activity [ED50 = 70.95 ± 9.24 mg/kg (APL), 27.02 ± 1.96 mg/kg (APSB), 32.47 ± 3.03 mg/kg (Paracetamol)]. Tannins, flavonoids, phytosterols, triterpenoids and coumarins were identified in A. pterocarpoides. This study has provided essential diagnostic characteristics for the quality control of A. pterocarpoides and justified its anti-inflammatory and antipyretic effects.

Key words: Pharmacognosy, carrageenan, Amphimas pterocarpoides, pyrexia, inflammation.