Journal of
Pharmacognosy and Phytotherapy

  • Abbreviation: J. Pharmacognosy Phytother.
  • Language: English
  • ISSN: 2141-2502
  • DOI: 10.5897/JPP
  • Start Year: 2009
  • Published Articles: 202

Full Length Research Paper

Catechins as antidiabetic compounds of Bridelia ferruginea Benth root bark extract

Batomayena Bakoma
  • Batomayena Bakoma
  • Department of Pharmacy, Faculty of Health Sciences, University of Lome, Togo.
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Benedicte Berke
  • Benedicte Berke
  • Department of Pharmacology, University of Bordeaux, 33076 Bordeaux, France.
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Aboudoulatif Diallo
  • Aboudoulatif Diallo
  • Department of Pharmacy, Faculty of Health Sciences, University of Lome, Togo.
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Kwashie Eklu-Gadegbeku
  • Kwashie Eklu-Gadegbeku
  • Department of Pharmacy, Faculty of Health Sciences, University of Lome, Togo.
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Kodjo Aklikokou
  • Kodjo Aklikokou
  • Department of Pharmacy, Faculty of Health Sciences, University of Lome, Togo.
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Messanvi Gbeassor
  • Messanvi Gbeassor
  • Department of Pharmacy, Faculty of Health Sciences, University of Lome, Togo.
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Nicholas Moore
  • Nicholas Moore
  • Department of Pharmacology, University of Bordeaux, 33076 Bordeaux, France.
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  •  Received: 08 August 2018
  •  Accepted: 18 September 2018
  •  Published: 31 October 2018

Abstract

The present study was carried out to evaluate the antidiabetic activity of catechins isolated from Bridelia ferruginea in previous studies. Epigallocatechin (EGC) and Epigallocatechin gallate (EGCG) isolated from B. ferruginea were administrated to streptozotocin-induced diabetic mice to evaluate their anti-hyperglycemic and anti-hyperlipidemic effects. Then, biochemical parameters were assayed in different groups of streptozotocin-induced diabetic mice. The level of fasting blood glucose levels, triglycerides (TG) and total cholesterol (TC) in streptozotocin-induced diabetic mice were significantly decreased after daily oral administration of EGC and EGCG at doses of 10 mg/kg/day, for 21 days.  Glucose intolerance was significantly reduced in streptozotocin induced diabetic mice treated with catechins. These results suggest that catechins constituents from B. ferruginea, revealed significant anti-hyperglycemic and antihyperlipidemic activity in type 2 diabetes.

Key words: Bridelia ferruginea, epigallocatechin,  streptozotocin, diabetes, medicinal plant.