The methanolic extract of Aristolochia ringens whole plant, commonly used in the traditional treatment of various diseases in humans and animal by some phytotherapist in Nigeria, was evaluated for anti-trypanosomal efficacy in mice infected with Trypanosoma congolense. Following three days dose intra-peritoneal administration, the extract produced anti-trypanosomal effect at the three dosage levels of the four tested that is, 433.2, 288.8 and 144.8 mg/kg body weight through the complete suppression or delay in parasite establishment. There was a reduction in the level of parasitaemia as well as enhanced survival of the infected mice, although the plant extract did not significantly (P < 0.05) increase the survival period of the mice compared to the negative control (infected untreated). The results suggest that the use of the extracts traditionally has a pharmacological basis.
Key words: Aristolochia ringens, Trypanosoma congolense, anti-trypanosomal.
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