Journal of
Pharmacognosy and Phytotherapy

  • Abbreviation: J. Pharmacognosy Phytother.
  • Language: English
  • ISSN: 2141-2502
  • DOI: 10.5897/JPP
  • Start Year: 2009
  • Published Articles: 222

Full Length Research Paper

Evaluation of phytochemical and pharmacological properties of Mikania cordata (Asteraceae) leaves

Abdullah Al Nayeem1, Amina Khatun2, Md. Shafiur Rahman1 and Mahmudur Rahman3*
1Pharmacy Discipline, Life Science School, Khulna University, Khulna-9208, Bangladesh. 2Department of Pharmacy, Manarat International University, Dhaka-1216, Bangladesh. 3Department of Pharmacy, Phytochemistry and Pharmacology Research Laboratory, Northern University Bangladesh, Dhaka-1215, Bangladesh.
Email: [email protected]

  •  Accepted: 21 September 2011
  •  Published: 19 September 2013

Abstract

The ethanol extract of the dried leaves of Mikania cordata (Family-Asteraceae) was investigated for its possible bioactive chemical groups and antinociceptive, cytotoxic and antibacterial activities in animal models. The extract produced significant writhing inhibition in acetic acid-induced writhing in mice at the oral dose of 125 and 250 mg/kg body weight (p<0.001) comparable to the standard drug diclofenac sodium at the dose of 25 mg/kg of body weight. The crude extract produced the moderate cytotoxic activity against brine shrimp Artemia salina(LC50=90 and LC90=166 µg/ml). The extract showed antibacterial activity against some types of microorganisms upon which the extract was employed. The obtained results provide a support for the use of this plant in traditional medicine and its further investigation.

 

Key words: Antimicrobial, antinociceptive, Asteraceae, cytotoxic, Mikania cordata.