Journal of
Pharmacognosy and Phytotherapy

  • Abbreviation: J. Pharmacognosy Phytother.
  • Language: English
  • ISSN: 2141-2502
  • DOI: 10.5897/JPP
  • Start Year: 2009
  • Published Articles: 223

Full Length Research Paper

Antiplasmodial, analgesic and anti-inflammatory effects of crude Guiera senegalensis Gmel (Combretaceae) leaf extracts in mice infected with Plasmodium berghei

Ali A. Jigam1*, Helmina O. Akanya1, Bukar E. N. Dauda2  and Emmanuel O. Ogbadoyi1
1Department of Biochemistry, Malaria and Trypanosomiasis Research Unit, Federal University of Technology, Minna, Nigeria. 2Department of Chemistry, Federal University of Technology, Minna, Nigeria.
Email: [email protected]

  •  Accepted: 26 September 2011
  •  Published: 30 November 2011

Abstract

Guiera senegalensis is acclaimed as a common herbal antipyretic and antimalarial among some tribal groups in northern Nigeria. Leaf extracts of the plant were thus tested for antiplasmodial, analgesic and anti-inflammatory effects in vivo. Results indicated the safe dose of extracts as 600 mg/kg body weight of mice with LD50 of 1100 mg/kg bw. Only the methanolic fraction had antiplasmodial effect while ethylacetate and hexane fractions were ineffective. Furthermore the methanolic extract produced a significant (p<0.05) suppression of up to 67.52% levels. The extracts had no prophylactic effect and high parasitaemia including mortality of sub-inoculated mice were obtained on day 14 post treatment. It gave 44.83% analgesic effect but was devoid of anti-inflammatory activity. Phytochemical screening indicated the presence of alkaloids, glycosides, tannins and flavonoids.

 

Key words: Antipyretic, analgesic, antiplasmodial, anti-inflammatory, phytochemical.