Journal of
Pharmacognosy and Phytotherapy

  • Abbreviation: J. Pharmacognosy Phytother.
  • Language: English
  • ISSN: 2141-2502
  • DOI: 10.5897/JPP
  • Start Year: 2009
  • Published Articles: 223

Full Length Research Paper

Effect of Hippocratea africana root bark extract on some biochemical indices of male and female albino Wistar rats

J. I. Ndem1*, M. U. Eteng2, M. I. Akpanabiatu1, A. F. Uwah1, O. Otitoju3 and E. O. Akpanyung1
1Department of Biochemistry, Faculty of Basic Medical Sciences, University of Uyo, Uyo, Akwa Ibom State, Nigeria. 2Department of Biochemistry, Faculty of Basic Medical Sciences, University of Calabar, Calabar, Cross River State, Nigeria. 3Department of Biological Sciences, Faculty of Pure and Applied Sciences, Federal University of Wukari, Taraba State, Nigeria.
Email: [email protected]

  •  Accepted: 29 January 2013
  •  Published: 30 April 2013


The benefits of medicinal plants may not be without some biochemical impediments. Anti-plasmodial activity of Hippocratea africana has been studied; its effects on some biochemical parameters were examined in rats in this study. It was observed that in the female test groups, there was no significant (p > 0.05) changes in urea concentration but there was significant (p < 0.05) increase in glucose concentration. There was also a slight increase in total protein and albumin concentrations which was not significant (p > 0.05). The male treatment groups however recorded significant (p < 0.05) increases in glucose, total protein, urea and albumin except for serum bilirubin which showed slight but non-significant (p > 0.05) decrease. The result generally does not suggest any biochemical imbalance and therefore the herb may be safe for use for its anti-plasmodial property.


Key words: Hippocratea africana, biochemical imbalance, glucose, total protein, urea, albumin, bilirubin, anti-plasmodial property, health benefit.