Journal of
Pharmacognosy and Phytotherapy

  • Abbreviation: J. Pharmacognosy Phytother.
  • Language: English
  • ISSN: 2141-2502
  • DOI: 10.5897/JPP
  • Start Year: 2009
  • Published Articles: 227

Full Length Research Paper

Phytochemical profiling, body weight effect and anti-hypercholesterolemia potentials of Cnidoscolus aconitifolius leaf extracts in male albino rat

Chukwu, Ezinne. C.
  • Chukwu, Ezinne. C.
  • Department of Biochemistry, Federal University of Lafia, Nasarawa State, Nigeria.
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Osuocha, Kelechi U.
  • Osuocha, Kelechi U.
  • Biochemistry Unit, Department of Science Laboratory Technology, Federal University of Lafia, Nasarawa State, Nigeria.
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Iwueke, Adaku V
  • Iwueke, Adaku V
  • Department of Biochemistry, PAMO University of Medical Sciences, Rivers State, Nigeria.
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  •  Received: 23 October 2016
  •  Accepted: 16 November 2016
  •  Published: 30 April 2020


The present study investigated the phytochemical constituents of Cnidoscolus aconitifolius leaves extracts and its anti-hypercholesterolemia potentials using standard analytical methods. Forty five male albino rats weighing (115-121 g), divided into nine groups of five rats were used.  Group I served as the control while the other groups were administered 200, 400, 600 and 800 mg/kg body weight of aqueous and ethanol leaf extracts. GC-MS analysis showed 3,7,1,5-tetramethyl-2-hexadecen-1-ol, farnesyl bromide, β–sitosterol, squalene, β-amyrin, 1-heptatriacotanol, hexadecanoic acid, methyl ester, 2-pentadecanone, 6,10,14-trimethyl- ,n-hexadecanoic acid, 9,12-octadecadienoyl chloride, (Z,Z, δ- tocopherol, Ergosta-5,22-dien-3-ol acetate, (3β,22E)-, 9,10-secocholesta-5,7,10(19)-triene-3,24,25-triol, (3β,5Z,7E)-acetamide, N-methyl-N-[4-(3-hydroxypyrrolidinyl)-2-butynyl]-, 1-gala-I-ido-octose, 10-methyl-E-11-tridecen-1-ol propionate, dodecanoic acid, 2-(acetyloxy)-1-[(acetyloxy)methyl]ethyl ester, 11,14-octadecadienoic acid, methyl ester, cyclopentaneundecanoic acid and methyl ester. Lipid profile showed significant reduction in TC, LDL and TG with increase in HDL in dose dependent ratio. This shows that extracts of this plant could be useful in treatment of coronary heart diseases.               

Key words: Phytochemicals,hypercholesterolemia, Cnidoscolus aconitifolius, potentials.