Full Length Research Paper
Abstract
Acne is a dermatosis of the pilosebaceous follicles usually treated with topicals. Aloe vera and Ocimum gratissimum are used in traditional medicine to treat this condition. The aim of this study was to formulate and compare the anti-acne efficacy of a hydrogel and an emugel based on Aloe vera and O. gratissimum. Three herbal topicals containing A. vera gel associated with respectively 5% of essential oil of O. gratissimum, 5 and 10% of O. gratissimum hydroethanolic extract have been formulated. The physicochemical properties of the gels such as homogeneity, spreadability, viscosity, pH, stability, and irritability were assessed. The antimicrobial activity of the gels was evaluated through agar diffusion method. The gels containing O. gratissimum at 5% showed good homogeneity, stability, a pH compatible to skin, and did not induce any irritation. However, only the emulgel depicted the most potent activity against methicillin-resistant Staphylococcus aureus and coagulase-negative Staphylococcus. The results indicate that the O. gratissimum emulgel is a promising alternative for acne treatment.
Key words: Acne vulgaris, Ocimum gratissimum, herbal topical preparations, antimicrobial activity.
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