Journal of
Pharmacognosy and Phytotherapy

  • Abbreviation: J. Pharmacognosy Phytother.
  • Language: English
  • ISSN: 2141-2502
  • DOI: 10.5897/JPP
  • Start Year: 2009
  • Published Articles: 223

Pharmacognostic and hypoglycemic studies of Achyranthus aspera L.

Ishtiaq Ahmad1, Muhammad Ibrar1, Barkatullah1, Naveed Muhammad2*, Zahir Muhammad1 and Niaz Ali1
1Department of Botany, University of Peshawar, Peshawar, KPK, Pakistan. 2Department of Pharmacy, Hazara University, Havelain Campus, Abbottabad, KPK, Pakistan.
Email: [email protected]

  •  Accepted: 27 May 2013
  •  Published: 31 July 2013

Abstract

In the present study, the ethanolic extract of Achyranthus aspera L. Leaves (EEA) were investigated for their pharmacognostic characteristics and hypoglycemic effects. The pharmacognosy of the plant was carried out using microscopic and macroscopic tools. Macroscopic studies revealed that the leaves were cauline, ramel, opposite, exstipulate, simple, sub-sessile, ovate, entire, acute, unicostate, reticulate, rough, coriaceous and hairy. The stem was erect, herbaceous, quadrangular, branched, solid, green and pubescent, while various internal parts were observed using powder drug for microscopic study. The hypoglycemic effect of the plant was studied in healthy normoglycemic rabbits. The EEA was tested in three doses (100, 150 and 200 mg/kg), and a dose dependent hypoglycemic effect was observed. The most significant hypoglycemic effect was observed against higher dose (200 mg/kg) which remained for 5 h while the hypoglycemic effect remained significant for 3 h against the lower dose. It was concluded that EEA has hypoglycemic properties and it is recommended for the treatment of diabetes mellitus II.

 

Key words: Pharmacognostic, hypoglycemic, Achyranthus aspera L.