Journal of
Pharmacognosy and Phytotherapy

  • Abbreviation: J. Pharmacognosy Phytother.
  • Language: English
  • ISSN: 2141-2502
  • DOI: 10.5897/JPP
  • Start Year: 2009
  • Published Articles: 223

Article in Press

Laurus nobilis leaves extract protects against high fat diet-induced type 2 Diabetes in rats

Costantine F Daher1, Robin I Taleb1, Mohamad A Mroueh2, Bilal Nehmeh1, Hachem Araji1, Rawan H Chakas1, Aimee M Daccache1, Kamar H Eid1, Maria K El Khoury1, Pamela F El Hayek1, Hala T Faddoul1, Elio Junior Feghali1, Ahmad G Ghanem1, Tony P Haydar1, Abir R Jammoul1, Sula H Nasra1, Nouhad Saade1, Donna G Tahan1, Joey C. Daher3, Esther Tannoury3, Wassim N Shebaby*2

  •  Received: 27 May 2021
  •  Accepted: 25 August 2021
Laurus nobilis, commonly known as bay, is used in folk medicine as a remedy for many ailments. The present study investigates the protective effect of L. nobilis leaves extract against high fat diet-induced type 2 diabetes in rats. Animals were divided into group 1 (control), groups 2, 3, and 4 (bay leaves aqueous (AQ) extracts; 50, 100, and 250 mg/kg of body weight respectively), and groups 5, 6, and 7 (bay leaves methanol/acetone (MeAc) extract; 50, 100, and 250 mg/Kg of body weight respectively). Animals were fed an isocaloric high fat diet for four weeks. The intake of bay leaves extracts was associated with a significant decreases in serum levels of glucose (AQ, 100 and 250 mg/kg; MeAc, 50, 100, and 250 mg/kg) and serum triglyceride (AQ, 250 mg/kg; MeAc, 100, and 250 mg/kg) as well as lower abdominal fat (all AQ and MeAc groups) and body weight gain (MeAc groups only). In conclusion, L. nobilis leaves extract intake provides a protective remedy against high fat diet-induced type 2 diabetes.

Keywords: Laurus nobilis; type 2 diabetes; bay leaves; high fat diet