Journal of
Pharmacognosy and Phytotherapy

  • Abbreviation: J. Pharmacognosy Phytother.
  • Language: English
  • ISSN: 2141-2502
  • DOI: 10.5897/JPP
  • Start Year: 2009
  • Published Articles: 224

Full Length Research Paper

Phytochemical profiling, body weight effect and anti-hypercholesterolemia potentials of Cnidoscolus aconitifolius leaf extracts in male albino rat

Chukwu, Ezinne. C.
  • Chukwu, Ezinne. C.
  • Department of Biochemistry, Federal University of Lafia, Nasarawa State, Nigeria.
  • Google Scholar
Osuocha, Kelechi U.
  • Osuocha, Kelechi U.
  • Biochemistry Unit, Department of Science Laboratory Technology, Federal University of Lafia, Nasarawa State, Nigeria.
  • Google Scholar
Iwueke, Adaku V
  • Iwueke, Adaku V
  • Department of Biochemistry, PAMO University of Medical Sciences, Rivers State, Nigeria.
  • Google Scholar


  •  Received: 23 October 2016
  •  Accepted: 16 November 2016
  •  Published: 30 April 2020

References

Aberoumand A, Deokule SS (2009).Studies on nutritional values of some wild edible plants from Iran and India. Pakistan Journal of Nutrition 8(1):26-31.
Crossref

 

Akinpelu DA, Onakoya TM (2006). Antimicrobial activities of medicinal plants used in folklore remedies in South- West. African Journal of Biotechnology 5:1078-1081.

 

Anofi OT, Mutiu IK (2015).Toxicopathological evaluation of hydroethanol extract of Dianthus basuticus in wistar rats. J. Evi-Bas. Complementary and Alternative Medicine 10(3):87-99.
Crossref

 

Araujo TAS, Alencar NL, Amorim ELC, Albuquerque UP (2008). A new approach to study medicinal plants with tannins and flavonoids contents from the local knowledge. Journal of Ethnopharmacology 120:72-80.
Crossref

 

Awoyinka OA, Balogun IO, Ogunnowo AA (2007). Phytochemical screening and in vitro bioactivity of Cnidoscolus aconitifolius. Journal of Medicinal Plant Research 1(3):63-65.

 

Chinyere GC, Ikpoh JC, Osuocha KU (2015). Serum lipid profile and liver enzymes of rats fed Lageneria sphaerica (wild bottle gourd) supplemented diet. International Research Journal of Biochemistry and Biotechnology 2(2):28-36.

 

Dhanalakshmi R, Manavalan R (2014). Bioactive Compounds in Leaves of Corchorus trilocularis L. by GC-MS Analysis. International Journal of PharmTech Research 6(7):1991-1998.

 

Ebeye OA, Ekundina VO, Ekele CM, Eboh DEO (2015). The histological effect of Cnidoscolus aconitifolius aqueous leaf extracts on the archetecture of the ovary, testis and sperm cells of adult wistar rats. International Journal of Herbs and Pharmacological Research 4(1):7-17.

 

Ezekwe AS, Elekwa I, Osuocha KU (2014). Hypoglycemic, hypolipidemic and body weight effects of unripe pulp of Carica papaya using diabetic albino rat model. Journal of Pharmacognosy and Phytochemistry 2(6):109-114.

 

Fossati P, Prencipe L (1982). Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide. Journal of Clinical Chemistry 28(10):2077-80.
Crossref

 

Hussein JH, Mohammed YH, Imad HH (2016). Study of chemical composition of Foeniculum vulgare using Fourier transform infrared spectrophotometer and gas chromatography-mass spectrometry. Journal of Pharmacognosy and Phytotherapy 8(3):60-89.
Crossref

 

Jun L, Stefan W, Chunlin X (2015). A review of bioactive plant polysaccharides: Biological activities, functionalization and biomedical application. Journal Bioactive Carbohydrates and Dietary Fibre 5(1):31-61.
Crossref

 

Kala SMU, Balasubramanian T, Tresina S, Mohan VR (2011). GC-MS determination of bioactive components of Eugenia singampattiana Bedd. International Journal of Chemical Technology Research 3:1534-1537.

 

Lacko AG, Barter P, Ehnholm C, Van-Tol A (2000). International symposium on basic aspects of HDL metabolism and disease prevention. Journal of Lipid Research 41(10):1695-1699.

 

Mathew JP (2000). Liver enzymes. In principles of health. White man publications. New York pp. 130-136.

 

Mina M, Farida AB, Amal R, Abdel AE, Hassane M, Nourdinne B, Mohammed L (2015). Study on chemical components of ethanol extractives of Dipcadis erotinum (Hyacinthaceae) By GC/MS. Intern. International Journal of Current Research and Academic Review 3(9):134-139.

 

Mohale DS, Dewani AP, Saoji AN, Khadse CD (2008). Anti-hyperlipidemic activity of isolated constituents Lageneria species in albino rats. International Journal of Green Pharmacy 2:817-827.
Crossref

 

Mordi JC , Akanji MA (2012). Phytochemical screening of the dried leaf extract of Cnidoscolus aconitifolius and associated changes in liver enzymes induced by its administration in Wistar Rats. Current Research Journal of Biological Sciences 4(2): 153-158.

 

Mordi J, Uzuegbu U, Nwangwa E, Okunima A (2013). Effect of the dry aqueous leaf extract of Cnidoscolus aconitifolius on blood alcohol clearance in rabbits. Journal of Natural Sciences Research 3(5):91-95.

 

Obichi EA, Monago CC,Belonwu DC (2015).Effect of Cnidoscolus aconitifolius (Family Euphorbiaceae) Aqueous Leaf Extract on Some Antioxidant Enzymes and Haematological Parameters of High Fat Diet and Streptozotocin Induced Diabetic Wistar Albino Rats. Journal of Applied Sciences and Environmental Management 19(1):201-209.\
Crossref

 

Odokuma EI (2012). Histological effects of alcoholic extract of Cnidoscolus aconitifolius on bone marrow biopsy in adult male Wistar Rats. Basic Sciences of Medicine 1(1):6-8.
Crossref

 

Olaleye MT (2007). Cytotoxicity and antibacterial activity of methanolic extract of Hibiscus sabdariffa. Journal of Medicinal Plants Research 1(1):9-13.

 

Olayinka AO, Onoruvwe O, Lot TY (1992). Cardiovascular effects of the methanolic extracts of the stem bark of Khaya senegalensis. Phytotherapy Research 6(5):282-284.
Crossref

 

Oluwatosin AA, Adekunbi A, Ademola AO (2011). Cnidoscolus aconitifolius leaf extract protects against hepatic damage induced by chronic ethanol administration in wistar rats. Alcohol and Alcoholism 46(4):451-458.
Crossref

 

Omotoso AE, Eseyin OO, Suleiman M (2014a). Phytochemical analysis of Cnidoscolus aconitifolius (Euphorbiaceae) leaf with Spectrometric Techniques. Nigerian Journal of Pharmaceutical and Applied Science Research 3(1):38-49.

 

Oyeyemi MO, Ajani OS (2014). Haematological parameters and serum testosterone of West African dwarf rams treated with aqueous extract of Cnidoscolus aconitifolius (Chaya). Journal of Medicinal Plants Research-Academic Journals 8(14):571-575.
Crossref

 

Prabhadevi V, Sathish S, Johnson M, Venkatramani B, Janakiraman N (2012). Phytochemical studies on Allamanda cathartica L. using GC-MS. Asian Pacific Journal of Tropical Biomedicine 2(2):550-554.
Crossref

 

Rency RC, Vasantha K, Maruthasalam A (2015). Identification of bioactive compounds from ethanolic leaf extracts of premna serratifolia L. using GC-MS. Journal of Biosciences 6(2):96-101.

 

Ross-Ibarra J, Molina-Cruz A (2002). The Ethnobotany of Chaya (Cnidoscolus aconitifolius): A Nutritious Maya Vegetable. Economic Botany 56:350-364.
Crossref

 

Sofowora A (1993). Medicinal Plants and Traditional Medicines in Africa. Chichester John Wiley and Sons New York pp. 97-145.

 

Sakpa CL, Okhimamhe AF (2014). Effects of aqueous leaf extract of Chaya (Cnidoscolus aconitifolius) on pituitary‑gonadal axis hormones of male Wistar rats. Journal of Experimental and Clinical Anatomy 13(2):34-39.
Crossref

 

Sowmya S, Gopalakrishnan VK, Poornima K (2015). Enzymatic and non enzymatic antioxidant activity of Tabernaemontana divaricate R.Br. against DEN and Fe-NTA induced renal damage in Wistar Albino Rats. Journal of Applied Pharmaceutical Science 5(5):33-37.

 

Ugwu CE, Olajide JE, Alumana EO, Ezeanyik LUS (2011). Comparative effects of the leaves of Vernonia amygdalina and Telfairia occidentalis incorporated diets on the lipid profile of rats. African Journal of Biochemistry Research - Academic Journals 5(1):28-32.

 

Urooj A, Fazal S, Muhammad S, Shehla A, Nisar A, Gowhar A, Khwaja F, Robert DES (2016). Passiflora incarnate attenuation of neuropathic allodynia and vulvodynia apropos GABA-ergic and opioidergic antinociceptive and behavioural mechanisms. Complementary and Alternative Medicine 16:77-83.
Crossref

 

Yakubu MT, Akanji MA, Oladiji AT, Olatinwo AO, Adesokan AA, Oyenike M, Yakubu RN, Owoyele BV, Sunmonu TO, Ajao SM (2008). Effect of Cnidoscolus aconitifolius leaf extract on reproductive hormones of female rats. Iranian Journal of Reproductive Medicine. 6:149-155.