Journal of
Pharmacognosy and Phytotherapy

  • Abbreviation: J. Pharmacognosy Phytother.
  • Language: English
  • ISSN: 2141-2502
  • DOI: 10.5897/JPP
  • Start Year: 2009
  • Published Articles: 223

Full Length Research Paper

Genotoxic effects of Peganum harmala L. in relation to traditional use

Salim M. Abderrahman
  • Salim M. Abderrahman
  • Department of Biology and Biotechnology, The Hashemite University, P. O. Box 150459, Zarqa, Jordan.
  • Google Scholar
Sameh Soliman
  • Sameh Soliman
  • Sharjah Institute for Medical Research, Collage of Pharmacy, University of Sharjah, Sharjah, UAE.
  • Google Scholar
Mohammad G. Mohammad
  • Mohammad G. Mohammad
  • Department of Medical Laboratory Sciences, Collage of Health Sciences, University of Sharjah, Sharjah, UAE.
  • Google Scholar

  •  Received: 14 February 2018
  •  Accepted: 11 May 2018
  •  Published: 30 September 2018


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Abderrahman SM (2004). Mitodepressive effect of Rubia cordifolia extract on the bone marrow cells of mice. Cytologia, 69(3):307-311.


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Begum S, Ali NS, Farhat F, Hassan IS, Siddiqui SB (2008). A simple, rapid and mild one pot synthesis of benzene ring acylated and demethylated analogues of harmine under solvent-free conditions. Molecules 13(8) 


Benbott A, Bahri L, Boubendir A, Yahia A (2013). Study of the chemical components of Peganum harmala and evaluation of acute toxicity of alkaloids extracted in the Wistar albino mice. Journal of Materials and Environmental Science, 4:558-565.


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Das A, Mukherjee A, Chakrabarti J (2004). Sanguinarine: an evaluation of in vivo cytogenetic activity. Mutation Research - Genetic Toxicology and Environmental. Mutagen, 563(1):81-87.


Di Giorgio C, Delmas F, Ollivier E, Elias R, Balansard G, Timon-David P (2004). In vitro activity of the β-carboline alkaloids harmane, harmine, and harmaline toward parasites of the species Leishmania infantum. Experimental Parasitology, 106(3):67-74.


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Fenech M, Kirsch-Volders M, Natarajan AT, Surralles J, Crott JW, Parry J, Norppa H, Eastmond DA, Tucker JD, Thomas P (2011). Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells. Mutagenesis, 26(1):125-132.


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Jiménez J, Riverón-Negrete L, Abdullaev F, Espinosa-Aguirre J, Rodríguez-Arnaiz R (2008). Cytotoxicity of the β-carboline alkaloids harmine and harmaline in human cell assays in vitro. Experimental and Toxicologic Pathology, 60(4):381-389.


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Majak P, Rychlik B, Pułaski Ł, Błauż A, Agnieszka B, Bobrowska-Korzeniowska M, Kuna P, Stelmach I (2010). Montelukast treatment may alter the early efficacy of immunotherapy in children with asthma. Journal of Allergy and Clinical Immunology, 125(6):1220-1227.


Mekki L, Mohammed A, Mansour H, Mansour H (2015). Genotoxic effect of Peganum harmala extracts on the growth of Viccia faba L and DNA using nuclear microsatellites. Pakistan Journal of Botany, 47(3):995-1006.


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Moloudizargari M, Mikaili P, Aghajanshakeri S, Asghari MH, Shayegh J (2013). Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids. Pharmacognosy Reviews, 7(14):199-212.


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Rafie H, Soheila H, Mohsen H, Marriam Z, Mahnaz S (2017). Alkaloidal content, medicinal, properties of Peganum harmala L. (P. harmala). Current Traditional Medicine, 3:1-11. 



Saadabi AMA (2006). Antifungal activity of some Saudi plants used in traditional medicine. Asian Journal Plant Science, 5(5):907-909.


Santos FV, Colus IMS, Silva MA, Vilegas W, Varanda EA (2006). Assessment of DNA damage by extracts and fractions of Strychnos pseudoquina, a Brazilian medicinal plant with antiulcerogenic activity. Food Chemical Toxicology, 44(9):1585-1589.


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Tahraoui A, El-Hilaly J, Israili ZH, Lyoussi B (2007). Ethnopharmacological survey of plants used in the traditional treatment of hypertension and diabetes in south-eastern Morocco (Errachidia province). Journal of Ethnopharmacology, 110(1):105-117.


Tawab SA, Adam ZM, SH S (2004). Suppression of mitotic process associated with metaphase arrest of Allium cepa L. roots using: I. Rosmarinus officinalis L. water extract. International Journal of Agriculture and Biology, 6(4):1560-8530.


Tursunkhodjaeva F, N S (2015). Neuroprotective and antinociceptive activity of two new derivatives of deoxypeganine Alkaloid. ‎Journal of Pharmacy and Pharmacology, 3(5):56-60.


Waki H, Park KW, Mitro N, Pei L, Damoiseaux R, Wilpitz DC, Reue K, Saez E, Tontonoz P (2007). The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARγ expression. Cell Metabolism, 5(5):357-370.