Journal of
Parasitology and Vector Biology

  • Abbreviation: J. Parasitol. Vector Biol.
  • Language: English
  • ISSN: 2141-2510
  • DOI: 10.5897/JPVB
  • Start Year: 2009
  • Published Articles: 189

Full Length Research Paper

Histidine-rich protein-2 based malaria rapid diagnostic tests performance among febrile pregnant women in high malaria transmission area

Marc Christian TAHITA
  • Marc Christian TAHITA
  • Clinical Research Unit of Nanoro (CRUN)/Institut de Recherche en Sciences de la Santé (IRSS), Burkina Faso.
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Paul SONDO
  • Paul SONDO
  • Clinical Research Unit of Nanoro (CRUN)/Institut de Recherche en Sciences de la Santé (IRSS), Burkina Faso.
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Berenger KABORE
  • Berenger KABORE
  • Clinical Research Unit of Nanoro (CRUN)/Institut de Recherche en Sciences de la Santé (IRSS), Burkina Faso.
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Biebo BIHOUN
  • Biebo BIHOUN
  • Clinical Research Unit of Nanoro (CRUN)/Institut de Recherche en Sciences de la Santé (IRSS), Burkina Faso.
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Hamidou ILBOUDO
  • Hamidou ILBOUDO
  • Clinical Research Unit of Nanoro (CRUN)/Institut de Recherche en Sciences de la Santé (IRSS), Burkina Faso.
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Adama KAZIENGA
  • Adama KAZIENGA
  • Clinical Research Unit of Nanoro (CRUN)/Institut de Recherche en Sciences de la Santé (IRSS), Burkina Faso.
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Palpouguini LOMPO
  • Palpouguini LOMPO
  • Clinical Research Unit of Nanoro (CRUN)/Institut de Recherche en Sciences de la Santé (IRSS), Burkina Faso.
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Florence OUEDRAOGO
  • Florence OUEDRAOGO
  • Clinical Research Unit of Nanoro (CRUN)/Institut de Recherche en Sciences de la Santé (IRSS), Burkina Faso.
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Karim DERRA
  • Karim DERRA
  • Clinical Research Unit of Nanoro (CRUN)/Institut de Recherche en Sciences de la Santé (IRSS), Burkina Faso.
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Macaire NANA
  • Macaire NANA
  • Nanoro Health District, Ministry of Health, Burkina Faso.
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Yabré Edmond SAWADOGO
  • Yabré Edmond SAWADOGO
  • Nanoro Health District, Ministry of Health, Burkina Faso.
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Hermann SORGHO
  • Hermann SORGHO
  • Clinical Research Unit of Nanoro (CRUN)/Institut de Recherche en Sciences de la Santé (IRSS), Burkina Faso.
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Maminata TRAORE/COULIBALY
  • Maminata TRAORE/COULIBALY
  • Nanoro Health District, Ministry of Health, Burkina Faso.
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Halidou TINTO
  • Halidou TINTO
  • Clinical Research Unit of Nanoro (CRUN)/Institut de Recherche en Sciences de la Santé (IRSS), Burkina Faso.
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  •  Received: 18 October 2020
  •  Accepted: 07 July 2021
  •  Published: 13 August 2021

Abstract

The diagnosis of malaria in pregnancy remains a challenge due to the low parasite density and placental sequestration of Plasmodium falciparum. A field performance evaluation of a malaria diagnostic test was carried out in an intense transmission setting in Nanoro, Burkina Faso. Pregnant women with symptoms suggestive of malaria were recruited and their results compared with microscopy, the current gold standard for P. falciparum diagnosis. Overall, 60% (120/200) pregnant women were malaria positive when using RDT while 49% (98/200) were positive when using microscopy. The sensitivity, specificity, positive (PPV) and negative (NPV) predictive values were 98% (95% CI: 92.8-99.8), 76.5% (95% CI: 67-84.3), 80% (95% CI: 71.7-86.7) and 97.5% (95% CI: 91.3-99.7) respectively. The agreement between microscopy and RDT was strong (Kappa coefficient of 0.74) which is good for the test, although specificity was poor. Nevertheless, in remote settings where microscopy is unavailable, the use of this RDT can limit the over-prescription of antimalarial drugs.

Key words: Febrile pregnant women, HRP-2, RDT performance, high transmission, Burkina Faso.