July 2022

Surveillance of plasmepsin 2 copy number gene in Plasmodium falciparum isolates from Senegal

The development of resistance to antimalarial drugs is a major challenge for global malaria control. Full Plasmodium falciparum resistance to dihydroartemisinin–piperaquine treatment has been reported recently in Cambodia. These events were directly associated with increased copy number variations (CNVs) in the plasmepsin system, including the PfPlasmepsin 2 gene. Pfplasmepsin 2 copy number was the most...

Author(s): Amy Gaye, Tolla Ndiaye, Mouhamad Sy, Awa B. Deme, Baba Dieye, Yaye Die Ndiaye,  Mamadou Samb Yade, Mamadou Alpha Diallo, Khadim Diongue, Mamane N. Garba, Amy Bei, Ibrahima Mbaye Ndiaye, Aita Sene, Abdoulaye Tine, Sarah K. Volkman, Aida Sadikh Badiane and Daouda Ndiaye  

July 2022

Cross sectional study on prevalence of malaria case and malaria infection in children under 15 years after the military crisis in Bouake, Côte d’Ivoire

During the recent crisis in Côte d’Ivoire that lasted 9 years (2002-2021) many health workers were moved from the affected areas to safer places, The aim of the study is to update malaria epidemiology in one of the most affected area (Bouake city) after the crisis ended. Cross-sectional surveys were conducted in children aged 6 months - 14 years old, one in the rainy season and in the dry season in three...

Author(s): Serge-Brice ASSI, Lacinan OUATTARA, Bertin Ncho TCHIEKOI, Offianan Andre TOURE, Franck REMOUE, Kalou Dibert ZIKA, Norbert Lingue KOUASSI, Issa COULIBALY, Raphael N’GUESSAN, and Akre Maurice ADJA  

September 2022

In vitro efficacy of standard antimalarial drugs on parasitic isolates from patients with sickle cell disease (SCD) in Abidjan, Côte d'Ivoire

Malaria infection triggers off vaso-occlusive attacks in sickle cell patients, leading drastically to death. Sickle-cell patients use artemisinin-based combination therapies (ACTs) as recommended by the WHO to treat malaria infections to prevent these crises. The survey of sensitivity of parasites collected from sickle-cell patients needs is important to be re-specified. Red cells from these patients differ from others...

Author(s): Albert A. Gnondjui, André O. Touré, Eric A. Gbessi, Francis A. Yapo, Sylvain Beourou, Ibrahima Sanogo and Ronan Jambou,  

October 2022

High prevalence of Mansonella perstans infection maintained in South Benin by Culicoides milnei, Culicoides imicola, and Culicoides inornatipennis

Mansonellosis is a vector-borne infection caused by different species of filarial nematodes of the genus Mansonella, including ozzardi, perstans, and streptocerca. The infection is mainly transmitted by bloodsucking midges of the genus Culicoides. All Mansonella species are known to induce little to no symptoms in humans. Due to the asymptomatic nature of the infection, epidemiological and immunological data are almost...

Author(s): Codjo Laurent Azonvide, Tomabu Adjobimey, Haziz Sina, James Nyabuga Nyariki and Lamine Baba-Moussa