Potato (Solanum Tuberosum L.) is an important tuber crop in Ethiopia. However, the yield of the crop is often constrained by low and imbalanced nutrient supply in the soil. Therefore, a field experiment was conducted at MWU and Dinsho District to study the effect of vermi-compost and NPS fertilizers on yield and yield component of potato (Solanum Tuberosum L.) during 2016/17 main rainy season. Gudane cultivar as experimental material was used for the study. The treatment consisted of four levels of NPS (0, 50, 100 and 125 kg ha-1) and three levels of vermi-compost (2.5, 5 and 10 ton ha-1). The experiment was laid out as a randomized complete block design (RCBD) in a factorial arrangement, and replicated three times. Data were collected on traits such as: plant height, tiller number per plant, total tuber yield, number of tuber per plant, average tuber yield and tuber diameter. Among the different dosages of vermi-compost applied there has been a significant improvement in yield and yield components of potato amended with vermi-compost at 45 kg per ha and 2.5 g NPS per ha. The overall productivity of potato under the two sites especially in Dinsho was significantly greater in site treated with vermi-compost at a level of 45 kg per ha and NPS 2.5 g per ha fertilizer. The results of this study indicated that, application of vermi-compost in combination with NPS fertilizer has positive effects on growth, yield and yield related parameters of tuber potato. The highest growth, yield and yield component of traits obtained at the highest level of vermi-compost in Dinsho relative to Robe site. However, to determine the optimum crop response and treatment level by emphasizing the site soil difference, further investigation is recommended with the consideration of more than 45kg/ha levels of vermi-compost and soil types. In addition, further investigation with a special focus on modification of the preparation and application method of vermi-compost is suggested

Keywords: potato productivity, vermi-compost, NPS fertilizer Dinsho and Robe site