Heavy metals and their derivatives are a special class of toxic substances. Many metals are useful for industrial, agricultural and medical applications. Indeed, they can go back through the food chain and thus achievable to human being. Our aim is to study an example of heavy metals cadmium (CdCl2) at two concentrations 30 and 60 ppm on biological model Oryctolagus cuniculus that is often used in toxicological studies, and the possible neutralization using the Ca2+. We are interested firstly of estimating LD50 of CdCl2 that is in range of 70 to 150 mg/kg according DVGW and we found that the LD50 is 85.703 mg/kg of CdCl2, this valor is augmented with the addition of 30 ppm Ca2+ to 108.231 mg/kg which show the protective role of Ca2+. Our results also showed a significant increase in the protein level in treated rabbits with both doses, this augmentation is corrected with the addition of Ca2+at all days (7th, 16th and 21st). Impact of CdCl2 on total white blood cells (WBC) number showed a decrease in treatments with 30 ppm contrarily to the rabbits treated with 60 ppm where we found an increase; these perturbations are more or less corrected with Ca2+.
Key words: Oryctolagus cuniculus, heavy metals, cadmium, calcium, hematology, protein, detoxification.
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