Journal of
Toxicology and Environmental Health Sciences

  • Abbreviation: J. Toxicol. Environ. Health Sci.
  • Language: English
  • ISSN: 2006-9820
  • DOI: 10.5897/JTEHS
  • Start Year: 2009
  • Published Articles: 206

Full Length Research Paper

Toxic effects of heavy metals (cadmium plus mercury) on haematological parameters and DNA damage in Lates calcarifer

A. Chezhian
  • A. Chezhian
  • Centre of Advanced Study in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai-608502, Tamil Nadu, India
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D. Senthamilselvan
  • D. Senthamilselvan
  • Centre of Advanced Study in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai-608502, Tamil Nadu, India
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E. Suresh
  • E. Suresh
  • Centre of Advanced Study in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai-608502, Tamil Nadu, India
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R. Ezhilmathy
  • R. Ezhilmathy
  • Centre of Advanced Study in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai-608502, Tamil Nadu, India
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  •  Accepted: 05 October 2012
  •  Published: 30 November 2012

Abstract

The present study was carried out to evaluate the effects of toxic metals (cadmium plus mercury) on the haematology and DNA damage of fish, Lates calcarifer for every 24 h up to 96 h. A significant gradual decrease of haemoglobin (-35.01 to -24.11) and hematocrit (-35.01 to -31.78) was noted at acute concentration of cadmium plus mercury (3.0 ppm) as compared to that of control. The comet assay of fish blood cells exhibited a significant higher DNA damage and the highest OTM was observed in 96 h of acute mixed metals concentration. From this investigation, the results proved that the combined metal toxicity induced haematological and DNA damage of fish Lates calcarifer than individual metal toxicity.

 

Key words: DNA damage, haemoglobin, hematocrit, heavy metals, Lates calcarifer