Journal of
Veterinary Medicine and Animal Health

  • Abbreviation: J. Vet. Med. Anim. Health
  • Language: English
  • ISSN: 2141-2529
  • DOI: 10.5897/JVMAH
  • Start Year: 2009
  • Published Articles: 423

Full Length Research Paper

Effects of piroxicam on ketamine anaesthesia in West African Dwarf goats (Capra hircus)

NWANKWO Henry Chuwkuebuk
  • NWANKWO Henry Chuwkuebuk
  • Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Federal University of Agriculture, Makurdi, Benue State, Nigeria.
  • Google Scholar
ONYEYILI Patrick Azubuik
  • ONYEYILI Patrick Azubuik
  • Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Federal University of Agriculture, Makurdi, Benue State, Nigeria.
  • Google Scholar
SAGANUWAN Saganuwan Alhaj
  • SAGANUWAN Saganuwan Alhaj
  • Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Federal University of Agriculture, Makurdi, Benue State, Nigeria.
  • Google Scholar
ONMATA Gloria D.
  • ONMATA Gloria D.
  • Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Federal University of Agriculture, Makurdi, Benue State, Nigeria.
  • Google Scholar
OLADIPO Miriam O.
  • OLADIPO Miriam O.
  • Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Federal University of Agriculture, Makurdi, Benue State, Nigeria.
  • Google Scholar
NWAGBO Ambrose N.
  • NWAGBO Ambrose N.
  • Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Federal University of Agriculture, Makurdi, Benue State, Nigeria.
  • Google Scholar


  •  Received: 22 February 2022
  •  Accepted: 09 May 2022
  •  Published: 30 April 2025

References

Adams J (2017). Assessment and management of pain in small ruminants. Livestock 22(6):324-328.
Crossref

 

Afshar FS, Baniadam A, Marashipour SP (2005). Effect of xylazine-ketamine on arterial blood pressure, arterial blood ph, blood gases, rectal temperature, heart and respiratory rates in goats. Bulletin-Veterinary Institute in Pulawy 9(4):481-484.

 

Aithal HP, Amarpal Pratap K, Singh GR (1996). Clinical effects of epidurally administered ketamine and xylazine in goats. Small Ruminant Research 24(1):55-64.
Crossref

 

Aithal HP, Singh GRA, Kinjavdekar P, Pawde AM, Pratap K (2001). Analgesic and cardiopulmonary effects of intrathecally administered romifidine or romifidine and ketamine in goats (Capra hircus). Journal South African Veterinary Association 72(2):84-91.
Crossref

 

Allen DG, Dyson DH, Pascoe PJ, O'Grady MR (1986). Evaluation of a xylazine-ketamine hydrochloride combination in the cat. Canadian Journal of Veterinary Research 50(1):23-26.

 

Bourke DL, Malit LA, Smith TC (1987). Respiratory interactions of ketamine and morphine. Anesthesiology 66(2):153-156..
Crossref

 

Bush M, Custer R, Smeller J, Bush LM (1977). Physiologic measures of non-human primates during physical and chemical immobilization. Journal of American Veterinary Medical Association 17:866-869.
Crossref

 

Carroll GL, Boothe DM, Hartsfield SM, Maltinez EA, Spam AC, Hernandez A (2001b). Pharmacokinetics and pharmacodynamics of butorphanol in llamas after intravenous and intramuscular administration. Journal of American Veterinary Medical Association 219(9):1263-1268.
Crossref

 

Carroll GL, Boothe DM, Hartsfield SM, Wallor MK, Geller SC (2001a). Pharmacokinetics and selected behavioural responses to butorphanol and its metabolites in goats following intravenous and intramuscular administration. Veterinary Anaesthesiaa and Analgesia 28(4):188-195.
Crossref

 

Clements JA, Nimmo WS, Grant IS (1982). Bioavailability, Pharmacokinetics, and Analgesic Activity of Ketamine in Humans Journal of Pharmaceutical Sciences 71(5):539-542.
Crossref

 

Corssen G, Domino EF (1966). Dissociative anesthesia: Further pharmacologic studies and first clinical experience with the phencyclidine derivative CI-581.Anesthesia and Analgesia 45(1):29-40.
Crossref

 

De Rossi R, Junqueira AL, Beretta MP (2003). Analgesic and systemic effects of ketamine, xylazine and lidocaine after subarachnoid administration in goats. American Journal of Veterinary Research 64(1):51-56.
Crossref

 

Dell RB, Holleran S, Ramakrishnan R (2002). Sample size determination. Institute of Laboratory Animal Research Journal 43(4):207-213.
Crossref

 

Dripps RD, Eckenhoff JE, Vandam LD (1988). Introduction to anesthesia: principles of safe practice. 7th ed. Philadelphia: WB Saunders Co, pp. 223-235

 

Eilers H, Yost S (2015). General anesthetics. In basic and clinical pharmacology. G. Katzun, B. G., Masters, S. B. and Trevor, A. J. eds. Mc Graw Hill Newyork, P 1203.

 

El-Rwegi WM, Elgerwi AA, El-Mahmoudy AM (2015). Effects of non-selective (piroxicam) and selective (meloxicam) cyclo-oxygenase inhibitors on the intestinal contractility of rabbits. International Journal of Basic and Clinical Pharmacology 5:924-930.
Crossref

 

Febbri A, Cruccu G, Sperti P, Ridolfi M, Ciampani T, Leardi MG (1992). Piroxicam induced analgesia: evidence for a central component which is not opioid mediated. Eperientia 48(11-12):1139-1142.
Crossref

 

Flecknell PA (2006). Anaesthetia and perioperative care. In British Small Animal Veterinary Association (BSAVA) Manual of rabbit medicine and surgery. 2nd Ed. (P. Flecknell ed). British Small Rabbit Veterinary Association Publishing, Gloucester P 100.

 

Gravetter FJ, Wallnau LB (2004). Statistics for the behavioural sciences: A first course for students of psychology and education (3rd ed.) St Paul, MN: West Publishing Co.

 

Green CJ, Knight J, Precious S, Simpkin S (1981). Ketamine alone and combined with diazepam or xylazine in laboratory animals: a 10 year experience. Laboratory Animals 15(2):163-170..
Crossref

 

Grubb TL, Riebold TW, Huber MJ, (1993). Evaluation of lidocaine, xylazine, and a combination of lidocaine and xylazine for epidural analgesia in llamas. Journal of American Veterinary Medical Association 203(10):1441-1444.
Crossref

 

Gupta SK, Singla LD (2012). Diagnostic trends in parasitic diseases of animals. In: Veterinary Diagnostics: Current Trends. Gupta RP, Garg SR, Nehra V and Lather D (Eds), Satish Serial Publishing House, Delhi pp. 81-112.

 

Haskins SC (1996). Monitoring the anaesthetized patient. In: Veterinary Anaesthesia. Thurman J.C., Tranquilli W.J., Benson G.J., ed. Williams & Willkins pp. 409-423.

 

Hirota K, Lambert DG (2011). Ketamine: new uses for an old drug? British Journal of Anaesthesia 107(2):123-126.
Crossref

 

Hobbs DC (1983). Piroxicam pharmacokinetics: recent clinical result relating kinetics and plasma level to age, sex and adverse effects. American Journal of Medicine 81(Suppl. 58):22-28.

 

Hogan Q (2002). Animal pain models. Regional Anaesthetics and Pain Medicine 27(4):385-401.
Crossref

 

Kronenberg RH (2002). Ketamine as an analgesic: parenteral, oral, rectal, subcutaneous, transdermal and intranasal administration. Journal of Pain Palliative Care Pharmacotherapy 16(3):27-35.
Crossref

 

Kul M, Koc Y, Alkand F, Ogurtan Z (2000). The effects of xylazine-ketamine and diazepam-ketamine on arterial blood pressure and blood gases in dogs. Journal of Veterinary Research 4:123-132.

 

Lichtenberger LM, Zhou Y, Jayaraman V, Doyen JR, O'Neil RG, Dial EJ, Vok DE (2012). Insight into NSAID-induced membrane alterations, pathogenesis and therapeutics: characterization of interaction of NSAIDs with phosphotidylcholine. Biochimica et Biophysica Acta 1821(7):994-1002.
Crossref

 

National Research Council (US) Committee on Recognition and Alleviation of Pain in laboratory Animals (NRCCRAPLA-US) (2009). Recognition and assessment of pain in Laboratory Animals, National Academics Press, Washington DC., pp. 1-309.

 

Reich DL, Silvay G (1989). Ketamine: an update on the first twenty?five years of clinical experience. Canadian Journal of Anaesthesia 36(2):186-197.
Crossref

 

Saganuwan SA (2008). Antagonistic effects of ceftriaxone and sulphadimidine on ketamine and thiopentone anaesthetics in Nigeria local dogs. Animla Research International 5(2):883-887.
Crossref

 

Saganuwan SA (2016). Physicochemical and structure-activity properties of piroxicam- a mini review. Comparative Clinical Pathology 25(5):941-945.
Crossref

 

Saganuwan SA (2017a). Biochemical applications of polymers: A case study of non-CNS drugs becoming CNS acting drugs. Central Nervous System in Medicinal Chemistry 18(1):32-38.
Crossref

 

Saganuwan SA (2017b). Piroxicam: Source for synthesis of central nervous system (CNS) acting drugs. Central Nervous System Agents in Medicinal Chemistry 17(2):135-140.
Crossref

 

Saganuwan SA, Orinya OA (2015). Toxico-neurological effects of piroxicam in monogastric animals. Journal of Experimental Neuroscience 10:121-128.
Crossref

 

Sawynok J (2014). Topical and peripheral ketamine as an analgesic. Anesthesia and Analgesia 119(1):170-178.
Crossref

 

Tranquilly WJ, Grimm KA (2015). Introduction: Use, Definitions, History, Concepts, Classification, and Considerations for Anesthesia and Analgesia. InVeterinary Anaesthesia and Analgesia 5th ed., of Lumb and Jones WILEY Blackwell Pondicherry, India P 1060
Crossref

 

Walker BJ, Polaner DM, Berde CB (2019). Acute pain In A Practice of Anaesthesia for Infants and Children 6th ed., pp. 1023-1062
Crossref

 

World Health Organisation (1989). Model Prescribing Information: Drugs Used in Anaesthesia pp. 1-60

 

Wyatt JD, Scott RAW, Richardson ME (1989). The effects of prolonged ketamine-xylazine intravenous infusion on arterial blood pH, blood gases, mean arterial blood pressure, heart and respiratory rates, rectal temperature and reflexes in the rabbit. Laboratory Animal Science 39(5):411-416.

 

Zur E (2014). Topical Treatment of Neuropathic Pain Using Compound Medications. The Clinical Journal of Pain 30(1):73-91.
Crossref