Scientific Research and Essays

  • Abbreviation: Sci. Res. Essays
  • Language: English
  • ISSN: 1992-2248
  • DOI: 10.5897/SRE
  • Start Year: 2006
  • Published Articles: 2748

Full Length Research Paper

Effects of combinations of ethanolic extracts of Blighia sapida and Xylopia aethiopica on progesterone, estradiol and lipid profile levels in pregnant rabbits

  Odesanmi OS1*, Ayepola Olayemi2, Omotosho OE2, Ogunlana OO2, Frank Onwuka3 and Nwankpa Promise4
  1Department of Biochemistry, College of Medicine, University of Lagos, Idi-Araba, Lagos State, Nigeria. 2Department of Biological Sciences, College of Science and Technology, PMB 1023, Covenant University, Ogun State, Nigeria. 3Department of Biochemistry, University of Port Harcourt, Rivers State, Nigeria. 4Department of Biochemistry, Imo State University, Owerri, Nigeria.  
Email: [email protected]

  •  Accepted: 23 May 2013
  •  Published: 30 June 2013

Abstract

 

 

The effects of ethanolic extracts of Xylopia aethiopica fruits and Blighia sapidaroots, used by some rural dwellers in western part of Nigeria for arbortifacient purposes, were investigated using pregnant rabbits. A combination of X. aethiopicaand B. sapida in a ratio 1:1 at concentrations of 10.0 mg/ kg body weight (group B) and 50.0 mg/ kg body weight (group C), and X. aethiopica alone at 50.0 mg/kg of body weight (group D) were administered by gastric intubations for a period of 14 days from the 12th to 25th day of gestation after which they were fasted for 18 h. Serum levels of reproductive hormones (progesterone and estradiol) and lipids (triglycerides, total cholesterol, LDL-cholesterol and HDL-cholesterol) were determined at the end of the treatment. Results showed significant reductions (p < 0.05) in progesterone and estradiol levels, significant elevations of triglycerides (p < 0.05) and no statistically significant differences (p < 0.05) in the levels of total cholesterol in all the treated groups compared with the control (group A). There was a statistically significant reduction (p < 0.05) in the levels of HDL-cholesterol in Group B, a significant increase in group C and no significant reduction in group D compared with the control (group A). The levels of LDL-cholesterol in all the treated groups did not differ significantly (p < 0.05) from the control (group A). The results suggest that ethanolic extracts of X. aethiopica alone or in combination with B. sapida may actually lead to termination of pregnancy due to reduction of progesterone and estradiol. The results also suggest that there is increased risk of hypertriglyceridemia in the users of these plants but this may not predispose them to arteriosclerosis because of the insignificant differences in the levels of LDL-cholesterol in all the treated groups compared with the control.

 

Key words: Xylopia aethiopica, Blighia sapida, ethanolic extracts.