Scientific Research and Essays

  • Abbreviation: Sci. Res. Essays
  • Language: English
  • ISSN: 1992-2248
  • DOI: 10.5897/SRE
  • Start Year: 2006
  • Published Articles: 2753

Full Length Research Paper

Comparison of the tissue biocompatibility of Resilon and gutta-percha cones

Maryam Foroozia, 1*, Mamak Adel, 2, Marjan Nassiri-Asl, 3, Poopak Masumi, 4
1General Practitioner, School of Dentistry, Qazvin University of Medical Science, Qazvin, Iran. 2Department of Endodontics, School of Dentistry, Qazvin University of Medical Science, Qazvin, Iran. 3Department of Pharmacology, School of Medicine, Qazvin University of Medical Science, Qazvin, Iran. 4Department of Oral and Maxillofacial Pathology, School of Dentistry, Qazvin University of Medical Science, Qazvin, Iran.
Email: [email protected]

  •  Accepted: 19 March 2012
  •  Published: 31 March 2012

Abstract

The aim of this study was to evaluate the tissue biocompatibility of Resilon compared to gutta-percha cones. Three subcutaneous pockets were made in the back of 36 rats weighing between 200 to 250g. Subcutaneous pockets were left unfilled (control, 1 pocket) or filled with Resilon (1 pocket) or gutta-percha (1 pocket). At 3, 10, 30 and 90 days after implantation, 9 rats were killed and the materials were removed with their surrounding tissues. Histological samples were prepared, stained with hematoxylin-eosin (H&E), and observed under light microscopy, and intensity of tissue inflammatory response was assessed. Chi-square and Fisher’s exact tests were used for statistical analysis, with significance defined at the P<0.05 level. No significant differences were seen between the three groups at 3 or 10 days. There were significant differences in tissue reaction between the experimental groups and control group at 30 and 90 days. However, tissue reactions for Resilon and gutta-percha were similar at 30 and 90 days. Within the limits of this study, Resilon had similar tissue compatibility to gutta-percha on rat connective tissue.

 

Key words: Gutta-percha, Resilon, subcutaneous implantation, tissue-compatibility.