Scientific Research and Essays

  • Abbreviation: Sci. Res. Essays
  • Language: English
  • ISSN: 1992-2248
  • DOI: 10.5897/SRE
  • Start Year: 2006
  • Published Articles: 2754

Full Length Research Paper

Toxicity of Calotropis procera latex in pregnant and non-pregnant goats

S. M. A. El Badwi1 and A. O. Bakhiet2*
1Department of Medicine, Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Khartoum, Sudan. 2Department of Pathology, Parasitology and Microbiology, College of Veterinary Medicine and Animal Production, Sudan University of Science and Technology, Sudan.
Email: [email protected], [email protected]

  •  Accepted: 07 July 2010
  •  Published: 04 September 2010

Abstract

Experiments were carried out to examine the effect of Calotropis procera latex on pregnant and non-pregnant Nubian goats. In pregnant goats during 2 - 3 months of pregnancy, the latex was given at 0.3 ml/kg/day intra vaginally, the animals showed small amounts of mucus at the vulva and plugs, cried in pain and there was maternal and fetotoxicity on day 3 of the experiment. The toxicity was correlated with pathological changes which  include higher activities of aspartate aminotransferase (AST), alkaline phosphatase (ALP) and higher concentrations of creatinine, globulin, urea and progesterone while in non-pregnant goats given C. procera latex at 0.3 ml/kg/day or at 0.005 ml/kg/day intravaginally, showed vaginitis, anorexia and loss of condition..

 

Key words: Calotropis procera, latex, maternal and fetotoxicity, goats.