Scientific Research and Essays

  • Abbreviation: Sci. Res. Essays
  • Language: English
  • ISSN: 1992-2248
  • DOI: 10.5897/SRE
  • Start Year: 2006
  • Published Articles: 2753

Full Length Research Paper

Management and prognosis of HIV infected patients with postoperative sepsis

Baochi Liu1*, Changjun Guo2, Li Liu1, Huafeng Zhou1, Lei Li1, Yanhui Si1, Ye Cao1, Hui Chen1 and Xin Liu1
1Department of Surgery, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China. 2Department of Surgery, Ruijin Hospital Shanghai, Jiao Tong University School of Medicine, Shanghai 200025, China.
Email: [email protected]

  •  Accepted: 06 May 2011
  •  Published: 04 June 2011

Abstract

To investigate the management and prognosis of HIV infected patients with postoperative sepsis, the clinical data of 126 HIV-infected patients aged 20 to 74 years including 114 males and 12 females were retrospectively analyzed. Patients were divided into 3 groups according to the pre-operative level of CD4+ cells: Group A (n = 73), <200 cells/μl; Group B (n = 36): 200 cells/μl ≤ CD4 + cells < 350 cells/μl; Group C (n = 17): ≥350 cells/μl. The operation was carefully performed aiming to reduce the damage to tissues. Antibiotic prophylaxis, treatments with anti-tuberculous, antifugal and anti-retroviral drugs and timely treatment of complications were carried out. In Group A, B and C, postoperative sepsis occurred in 32, 8 and 3 patients, respectively, of whom 4, 1 and 0 died of multiple organ dysfunction syndrome (MODS), respectively. Analysis showed the proportion of patients with sepsis in Group A was significantly higher than that in Group B and Group C, but no significant difference was found between Group B and C. The HIV infected patients with CD4 + cells <200 cells/μl had significantly increased risk for postoperative sepsis. Appropriate peri-operative treatment for HIV-infected patients may achieve favorable outcome.

 

Key words: Acquired immune deficiency syndrome, operative-risk evaluation,complication, sepsis.