Scientific Research and Essays

  • Abbreviation: Sci. Res. Essays
  • Language: English
  • ISSN: 1992-2248
  • DOI: 10.5897/SRE
  • Start Year: 2006
  • Published Articles: 2754

Full Length Research Paper

An experimental model to study pneumothorax in Rats

M.D Yucel Akkas1, Ekber Sahin1, Burcin Celik1, Aydin Nadir1, Sule Karadayi*2, Cesur Gumus3, Ziynet Cinar4 and Melih Kaptanoglu1
1Cumhuriyet University School of Medicine, Department of Thoracic Surgery, Sivas, 58140, Turkey. 2Cumhuriyet University School of Medicine, Department of Emergency Medicine, Sivas, 58140, Turkey. 3Cumhuriyet University School of Medicine, Department of Radiology, Sivas, 58140, Turkey. 4Cumhuriyet University School of Medicine, Department of Statistics, Sivas, 58140, Turkey.
Email: [email protected]

  •  Accepted: 02 December 2009
  •  Published: 31 January 2010

Abstract

Researchers have used various techniques to form pneumothorax in animals, but to date, no standard method or rate of pneumothorax has been defined. We tried to develop a standard and a safe method of pneumothorax model in this study. 12 female Wistar Albino rats weighing 200 - 220 g were used. Two groups (6 rats in each) were formed. Open pneumothorax was formed by 0.5 cm incision through the right, 5th intercostal space. The first group was held in open pneumothorax position for 1 min and the second group, for 2 min and the incisions were sutured. After 48 h, computed tomography of the rats were obtained and the pneumothorax rates were measured. The mean pneumothorax value was greater in Group II (13.89%) than in Group I and it was statistically significant (p < 0.05). The above mentioned method produces low rates of pneumothorax (10 - 15%), without injuring lung tissue. It should be useful for researchers, who plan to study lung physiology with low rates of pneumotohorax.

 

Key words:  Model, pneumothorax, rat, experimental pneumothorax.