Scientific Research and Essays

  • Abbreviation: Sci. Res. Essays
  • Language: English
  • ISSN: 1992-2248
  • DOI: 10.5897/SRE
  • Start Year: 2006
  • Published Articles: 2759

Full Length Research Paper

Antioxidant activities of Solenostemon monostachyus leaf extract using in vitro methods

  Tebekeme Okoko1* and Diepreye Ere2    
  1Biochemistry Programme, Department of Chemical Sciences, Niger Delta University, PMB71, Wilberforce Island, Bayelsa State, Nigeria. 2Pure and Applied Chemistry Programme, Department of Chemical Sciences, Niger Delta University, P.M.B. 71, Wilberforce Island, Bayelsa State, Nigeria.
Email: [email protected]

  •  Published: 16 February 2012



Solenostemon monostachyus is an important herb that is native to West and Central Africa. The leaves have been traditionally used for various medicinal purposes however the scientific basis for these effects is scarce. The aim of this study was to investigate the in vitro antioxidant and free radical scavenging abilities of S. monostachyus extract by assessing its hydrogen peroxide scavenging ability, hydroxyl radical scaveinging ability and ferric ion reducing ability. Other activities assessed are the ability of the extract to reduce hydrogen peroxide-induced erythrocyte haemolysis and lipid peroxidation. The results showed that the extract possessed significant abilities to scavenge hydrogen peroxide and hydroxyl radicals, and also significant ability to reduce ferric ions. The extract also possessed significant abilities to reduce lipid peroxidation and haemolysis in erythrocytes induced by hydrogen peroxide when compared with the ability of ascorbic acid to do the same. This is ascribed to the possession of antioxidant phytochemicals which acted in synergy, thus the plant could be exploited for pharmacological and neutraceutical purposes.


Key words: Solenostemon monostachyus, antioxidant, free radical, haemolysis, phytochemical.