Medicinal plants have gained considerable interest in treatment of various medical conditions including inflammation. Rosaceae
(the rose family) family of flowering plants having largest genus Prunus
(plums, peaches, cherries and almonds) is one of the most economically important families. In current study, anti-inflammatory activities of three fruit species Prunus persica, Prunus avium
and Prunus domestica
of family Rosaceae
and genus Prunus
were evaluated by both in-vitro
assays. Non-invasive bioengineering probe Mexameter MPA-5 was used to measure cutaneous erythema level in-vivo
, while for in-vitro
evaluation lipoxygenase assay was used. These medicinal plant extracts were entrapped in oil-in-water emulsions and applied on 33 healthy human female volunteers (22 years) to assess cutaneous erythema level. Methanol extracts of P. persica, P. avium
and P. domestica
depicted significant (P ≤ 0.05) lipoxygenase activity in-vitro
, that is, 58.73, 51.29 and 47.87%, respectively. Results of in-vivo
assay revealed that active formulations loaded with botanical extracts produced statistically significant decrease in skin erythema over respective controls after 48 h P. persica, P. avium and P. domestica
extracts can be used for isolation of new lead compounds with better anti-inflammatory activity. Results indicate that studied plants present potential for many natural products studies with high safety profile.
Key words: Anti-inflammatory, Prunus persica, Prunus avium, Prunus domestica, Lipoxygenase, Rosaceae.