Scientific Research and Essays

  • Abbreviation: Sci. Res. Essays
  • Language: English
  • ISSN: 1992-2248
  • DOI: 10.5897/SRE
  • Start Year: 2006
  • Published Articles: 2754

Full Length Research Paper

Effect on enhancing physical strength and anti-stress activity of flavonoids from the Chinese medicinal plant Epimedium koreanum Nakai

  Xiuling Ou1* and Wei Li2          
  1Tianjin Agricultural University, Tianjin City, 300384, People’s Republic of China. 2Dezhou University, Dezhou City, 253023, People’s Republic of China.
Email: [email protected]

  •  Accepted: 29 March 2010
  •  Published: 31 May 2010

Abstract

 

Flavonoids from the Epimedium koreanum Nakai (FEN) were elucidated on enhancing physical strength and anti-stress effects on in vivo using mice and rats. Swimming time to exhaustion of mice administered with the FEN (15 and 30 mg/kg body weigh for 7 days) significantly prolonged. When the FEN (15 mg/kg) was given to the rats for 7 days, including the 48 h stress period, the FEN showed a remarkable anti-stress effect on the weight of the adrenal, spleen, thymus, and thyroid. The FEN also significantly inhibited the increase in total cholesterol and the decrease in alkaline phosphatase levels as biochemical parameters of immobilization stress in rats. The results suggested that, FEN had effect on enhancing physical strength and anti-stress activity.

 

Key words: Flavonoids from the Epimedium koreanum Nakai, enhancing physical strength effects, anti-stress activity.