Journal of
Physiology and Pathophysiology

  • Abbreviation: J. Physiol. Pathophysiol.
  • Language: English
  • ISSN: 2141-260X
  • DOI: 10.5897/JPAP
  • Start Year: 2010

JPAP Articles in press

Acute Toxicity profile of ethanolic extracts of Croton gratissimus Burch and Schrankia leptocarpa DC in rats: Medicinal plants used in the treatment of arterial hypertension in Beninese traditional medicine

Article in Press

Croton gratissimus. Burch and Schrankia leptocarpa DC are two plants from the Beninese flora which are traditionally used for the treatment of arterial hypertension. The present study investigated the acute toxicity of ethanolic extracts of these plants. The experiment was conducted according to OECD guideline 423 category 5 using a single dose of 5000mg/kg of the extracts. The average lethal doses (LD50) of the extracts...

Author(s):Koutchiko Angélus Hénok Sègla, Attakpa Sèlidji Eugène, Akotegnon Rodrigue, Guinnin Félix, Sènou Maximin, Amoussa Abdou Madjid, Lagnika Latifou, Sina Haziz, Yédomonhan Hounnankpon, Baba-Moussa Farid, Sezan Alphonse, Baba-Moussa Lamine

Pathophysiological mechanisms of maternal pro-inflammatory mediators in preterm labour

Article in Press

Available therapeutic interventions for managing preterm labour have not been consistently successful due to controversies related to its etiology. However, multiple mechanisms, including inflammation play a significant role in the pathogenesis of preterm labour. The connective tissue extracellular matrix of the amniochorion contains collagen fibres that maintain the tensile strength of the amniochorion, resisting...

Author(s):Kwame Adu-Bonsaffoh, Fidelis Bayor

Intentional mismatch in primer design to stabilize discrimination of CFTR and adenovirus targets

Article in Press

The purpose of this study was to apply an intentional mismatch design technique for primer-based detection of gene targets. In this study, wild-type versus mutant cystic fibrosis transmembrane conductance regulator alleles as well as two related adenovirus B7 and E4 genomes were used to test discrimination of primers. Lambda viral DNA genome template as well as published primers versus purified human genome template were...

Author(s):Emma L. Bush, Katelyn D. Johnson, Akhil Sekar, Kate Gislason, Caleb W. Furlow, Michael J. Reiterman and Douglas B. Luckie†

Antifertility effects of crude extracts from Acacia nilotica pods and Albizia lebbeck stem bark in female multimammate rats, Mastomys natalensis

Article in Press

The study's main objective was to assess any pathophysiological significance of Acacia nilotica pods aqueous extract and Albizia lebbeck stem bark methanolic extract on the reproductive system of female multimammate rats (M. natalensis). A total of 60 sexually mature female rats were randomized into a 2 x 3 factorial experimental design for treatments (Control, A. nilotica, and A. lebbeck) and treatment duration (7 or 14...

Author(s):Lusekelo M. Mwangengwa, Gaymary G. Bakari, Noel L. Kanuya and Robert A. Max Department of Physiology, Biochemistry and Pharmacology. Sokoine University of Agriculture. P. O. Box , Morogoro. Tanzania. [email protected] [email protected], Department of Veterinary Surgery and Theriogenology. Sokoine University of Agriculture. P. O.

Investigating the anti-diabetic phytoconstituent(s) of Rauvolfia Vomitoria leaves by gas chromatography-mass spectrometry (GC-MS)

Article in Press

Rauvolfia vomitoria is a medicinal plant that has been implicated for various medicinal actions including anti-diabetic. But among the various literature on its anti-diabetic action, none has provided information on the phytoconstituents responsible for its anti-diabetic action, the mechanisms of action as well as its effect on plasma insulin and glucagon (the primary regulators on blood glucose). Thus the aim of this...

Author(s):Akpojotor P. and Ebomoyi M. I.

Impact of Heat stress on Blood and Serum Biochemistry Parameters in Rats

Article in Press

Twenty mature albino rats randomly assigned to two groups (n=10) were used for the study. Group A was exposed to the sun while group B was kept under a shade. The study was for 28 days. At the end of the study the effects of heat stress on haematology and serum biochemistry were determined. There was a significant increase (p > 0.05) in the packed cell volume of group A when compared to group B. Red blood cell counts of...

Author(s):Rita I. Odo, Samuel O. Onoja and Cyrus O. Osuagwu

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