August 2009
The HIV-based host derived R7V epitope; functionality of antibodies directed at it and the predicted implications for prognosis, therapy or vaccine development
Host protein beta-2 microglobulin (β2m) is incorporated into the HIV-1 coat during budding. Individuals not progressing to AIDS produce antibodies directed to an epitope contained in β2m which is designated R7V. These antibodies increased with duration of HIV-infection in non-progressor patients and protected against HIV replication. Purified R7V antibodies neutralized different HIV-1 isolates and did not bind...
August 2009
Mechanisms and molecular genetic bases of rapid speciation in African cichlids
African cichlid fishes are a textbook model of evolution in motion but the molecular genetic bases and mechanisms involved in their rapid speciation largely remain elusive. Emerging experimental evidence now suggests that African cichlids have undergone rapid speciation due to a combination of their molecular genetic potential and the influences of the environment on this potential. The genetic potential of the cichlids...
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